Hardware Startups

Sigma5 builds a full-stack platform combining spectral sensing, world models, and AI reasoning to detect material, composition, and condition that RGB and LiDAR cannot, such as transparent objects, crop stress, gas and fluid leaks, and corrosion. It serves industries including agriculture, energy, infrastructure, and robotics.

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SigmaTron International is an Electronic Manufacturing Services (EMS) provider that produces printed circuit board assemblies and fully assembled electronic products for diverse end-user markets. The company operates seven manufacturing facilities across the United States, Mexico, China, and Vietnam, with a procurement office in Taiwan.

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SignGlasses develops smart glasses technology that delivers real-time sign language interpretation services for Deaf and hard-of-hearing individuals. The company operates a service delivery and management platform designed to improve communication access and facilitate connections across diverse communities.

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Siren Marine builds cellular-based IoT devices and software that monitor boats in real time, sending critical alerts about conditions such as bilge and battery status to owners onshore. Its Connected Boat technology serves recreational boaters as well as boat dealers, OEMs/boat builders, fleet operators and other marine businesses.

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Skelo Wear develops protective wearable gear designed to reduce hand and wrist injuries for athletes, with a focus on sports such as football. The company markets performance and protection equipment for competitive athletes.

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SkyBell makes video doorbells and related smart home security devices with HD video streaming, two-way communication, and smart motion detection, plus a HOME911 emergency-services feature via a RapidSOS partnership. Its products are sold direct to consumers and to security companies across North America.

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SkyH2O develops utility-scale, industrial-grade Atmospheric Water Generation (AWG) facilities, bringing together executives across water, energy, engineering, EPC construction, project development, finance, and legal to deliver these projects. It positions itself as a triple-bottom-line impact company operating in the water and cleantech sector.

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Skylark Wireless provides wireless connectivity systems for first responders, linking radios, cameras, sensors, vehicles, and biometric monitors to support fire, police, and rescue operations in daily work and disaster response.

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SleepRes develops Kairos Positive Airway Pressure (KPAP), a pressure-delivery approach for treating sleep apnea, delivered through Kricket, an FDA-approved PAP device. The company serves sleep apnea patients and healthcare providers, aiming to improve therapy adherence compared to conventional CPAP.

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Slipstream Solutions develops medical technology to address fluid stasis and support recovery and rehabilitation for caregivers, trainers, and patients, with a focus on underserved populations.

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SmartWheels develops sensor-enabled tire technology that collects real-time vehicle and road data to enable advanced mobility applications. The company serves automotive manufacturers and mobility platforms seeking to improve vehicle performance, safety, and operational intelligence.

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Softeq Development is a technical software development company founded in 1997, providing firmware, hardware, embedded, mobile, and web engineering as well as complex IoT and AI systems for enterprise clients. It offers software outsourcing and product engineering services and also operates the Softeq Venture Fund.

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Sonablate Corp. develops HIFU (high-intensity focused ultrasound) technology for focal therapy, initially applied to treating prostate disease as an alternative to conventional treatments. Its systems are used by physicians, with plans to address a broader range of medical conditions.

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Sonim builds rugged mobile devices designed to withstand harsh conditions for people working in demanding environments. The company operates in the hardware and mobility device category.

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Sonivate Medical develops ultrasound-based medical devices, drawing on expertise in cardiac ultrasound and medical device engineering. The company is based in Portland, Oregon.

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Soter Technologies makes FlySense, a sensor device that detects vaping, cigarette smoke, and air quality changes while also monitoring for signs of bullying in areas where cameras are restricted. Its cloud-based portal serves school districts and other organizations aiming to maintain safer, healthier learning and working environments.

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Spectral Platforms develops imaging and sensing technologies based on optical and materials science innovations. The company was founded by Ravi Verma, a materials scientist with expertise in optics and MEMS, and is supported by a board of distinguished scientists and industry leaders.

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Spheryx develops Total Holographic Characterization technology for analyzing suspensions at the sub-visible particle level, including detecting protein aggregates and particles in biopharmaceuticals. Its analytical tools serve product development, manufacturing, and quality assurance across industries such as pharmaceuticals, cosmetics, chemicals, industrial fluids, and petroleum products.

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Spiral Water Technologies develops compact filtration and concentration products using patented technology for high solids removal in water reuse, industrial filtration, and food & beverage processing applications. The company serves water treatment operators and industrial customers seeking efficient separation and recovery solutions with lower capital and operating costs.

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Sports Engineering Inc. develops load management technologies and the Split Sole™ footwear concept, licensing the technology to footwear manufacturers and brands.

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Square Robot builds autonomous inspection robots, including its SR-3 platform, that perform on-stream internal inspections of aboveground storage tanks without taking them out of service, using high-resolution sensors and phased array ultrasonic testing. It serves operators in refining, petrochemicals, aviation, terminals, and power generation, delivering API 653 and EEMUA 159 compliant inspection data and reports.

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StairAssist Walker (SAW) makes a mobility device engineered for use on stairs, intended for rehab patients who otherwise improvise to get up and down stairs at home. Invented by a Doctor of Physical Therapy and clinically evaluated with rehab hospitals, it holds three USPTO utility patents.

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Stanley Ruth is a family-run HVAC company specializing in thru-the-wall heating and cooling unit installation and service for private residences in New York City. It focuses exclusively on residential clients, including co-op buildings and landmark properties.

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Starfighters Space operates a fleet of F-104 Starfighter jets capable of flying at Mach 2 to launch payloads into space. The company provides commercial air-launch space services and is pursuing an FAA launch license.

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