Hardware Startups

Rezonent designs low-power semiconductor solutions, including SRAMs and AI/ML inference circuits on advanced FinFET nodes. The company focuses on chip design for power management and high-performance computing markets.

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Rheia manufactures air distribution systems for building HVAC applications. The company provides technical specification sheets and performance data to support system design and compliance.

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Rheos Medical develops Clarity-IA, an anesthesia delivery system that converts existing hospital ventilators into the equivalent of a dedicated anesthesia machine for administering inhaled anesthetics and sedation during mechanical ventilation. The device is intended for use by trained healthcare professionals treating patients weighing 80-330 lbs.

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Riot Platforms is a Bitcoin mining and digital infrastructure company with vertically integrated operations spanning mining operations, engineering, and large-scale data center development.

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RMR Ortho develops bone fixation implants and instrument systems using Nitinol shape memory technology for orthopedic trauma and extremity surgery applications.

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RxAir360 is developing a monoplace hyperbaric oxygen therapy (HBOT) chamber designed to fit standard physician exam rooms in outpatient practices, aiming to expand access to hyperbaric medicine beyond hospital-based facilities. The device is in development in the United States and pursuing FDA 510(k) clearance; it is not yet cleared for clinical use or commercial sale.

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RxFunction develops Walkasins, a wearable lower limb sensory prosthesis that replaces lost nerve function for detecting and signaling foot pressure. It is intended for patients with peripheral neuropathy who have gait and balance impairments and are at high risk of falls.

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SAAZ develops advanced imaging sensors and cameras for military, space, and commercial applications, with technology spanning visible, infrared, and ultraviolet detection. The company provides mission-ready sensor solutions for space, airborne, and defense customers.

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SafePath Medical makes the FDA-cleared SafePath Safety Suturing Device, a suturing tool for catheter securement and wound closure designed to prevent needlestick and sharps injuries for healthcare workers. The device is sold to hospitals and, via a federal supply contract, to the VA, DoD, and other federal healthcare facilities in the US.

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SafetySpect develops miniaturized multimode spectroscopy systems powered by sensor hardware and AI/machine learning to detect hygiene and health risks across industries. Products are designed and manufactured in the USA.

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SAIL Spine develops spinal implant products for orthopedic applications, drawing on the founding team's extensive experience in medical device innovation and commercialization.

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Saleen Automotive is a specialty manufacturer of high-performance vehicles, including tuned Ford models, race cars, and proprietary supercars such as the Saleen S7 and Saleen S1, along with performance parts, custom styling upgrades, and track support. Founded in 1984 and handcrafting its vehicles in California, the company serves performance car enthusiasts across North America.

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Salus Scientific designs radiation protection solutions for healthcare providers, with a focus on eliminating occupational hazards in fluoroscopy and medical environments. The company's flagship product addresses the physical strain caused by traditional lead aprons used in medical imaging procedures.

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Scientific Industries sells laboratory equipment including vortex mixers, rotators, rockers, disruptors, and shakers under the GENIE brand for sample mixing, agitation, and cell disruption. It supplies these instruments directly from its own warehouse to laboratory and research users, primarily in the U.S.

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Scientific Lightning Solutions provides lightning monitoring systems, risk assessments, protection system design, inspections, and forensic investigations to help critical facilities mitigate lightning-related risks. The company serves industries requiring lightning safety and operational resilience.

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Securisyn develops endotracheal securement devices, including its flagship SolidAIRity Flex device for adults and a planned pediatric version. The company's products are medical devices not yet available for sale, with a planned U.S. launch in 2026.

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Thermal designs and manufactures thermal imaging sensors, cores, and components for firefighting, industrial monitoring, and OEM integration. It operates a fabless semiconductor model with U.S.-based design and manufacturing.

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Seigla Medical designs, develops, and manufactures medical devices for interventional physicians treating peripheral, cardiovascular, and neurovascular disease. The Minnesota-based company focuses on engineering and manufacturing products aimed at improving patient outcomes in vascular interventions.

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Senaptec develops sensory and vision training equipment, including strobe eyewear and sensory assessment stations, used by athletes and performance groups across sports such as baseball, basketball, football, soccer, and golf, as well as military applications. It sells these products direct to consumers and organizations through its online store.

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Sensus Healthcare develops Superficial Radiotherapy (SRT) medical devices, including the SRT-100, SRT-100+ and SRT-100 Vision (which adds high-frequency ultrasound imaging), used to treat non-melanoma skin cancer and keloids without surgery. The devices are sold to physicians, institutions and healthcare systems for non-invasive, in-office outpatient treatment.

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Sepragen develops chromatography and bioreactor systems for large-scale pharmaceutical and biopharmaceutical manufacturing, including vaccine production, monoclonal antibodies, and viral vectors. The company serves pharmaceutical manufacturers and contract manufacturers requiring purification and bioprocessing equipment at production scale.

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Shoot 360 operates basketball training facilities that combine coaching with technology, including AI-driven shot analytics, motion-tracking cameras, interactive drills, and virtual competition. Its proprietary Splash Meter provides instant feedback by measuring the arc, depth, and alignment of each shot for athletes of all ages and skill levels.

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Shoreline Bespoke designs and manufactures low-volume, road-legal sports cars that emphasize mechanical purity and driver engagement, drawing inspiration from 1960s racing prototypes. The company serves automotive enthusiasts and operates in California.

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SightLogix develops intelligent thermal camera systems using computer vision and embedded processing for perimeter security and intrusion detection at critical infrastructure and outdoor sites. Its products serve the physical security and homeland security market.

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