Digital Health Startups

Five Lives offers a brain health app for people over 50, combining brain training games and adapted physical activity to support memory, language and daily autonomy. Its program is built around five lifestyle pillars — nutrition, sleep, physical activity, mood & social, and mental stimulation — aimed at reducing dementia risk.

1 investor

Shasta provides AI agents that automate healthcare administrative workflows including patient eligibility verification, insurance communication, phone call handling, and referral management for healthcare providers. The platform integrates with existing EMR systems to reduce manual data entry and improve patient scheduling and verification processes.

1 investor

Shearwater Health provides Clinical Process Outsourcing (CPO), supplying a global team of clinicians and process experts to support healthcare organizations with clinical decision support and administrative work. It serves payers, providers, and workers' compensation and disability organizations to reduce administrative burden and improve care outcomes.

1 investor

Shields Health Solutions integrates specialty pharmacies into hospitals and care clinics, providing access to medications across approximately 50 specialty and rare disease states. The company serves health systems and hospitals through partnerships with 80+ health systems and over 1,000 hospitals and clinics across 47 states.

1 investor

Shift Health offers a personal concierge service combining human experts and AI to help individuals with health, family, relationships, and work needs through one continuous relationship.

1 investor

ShiftWizard, a product by HealthStream, is a mobile healthcare workforce scheduling and staffing platform used by health systems, hospitals, and departments to align staffing with patient demand and reduce labor costs. It offers self-scheduling, shift swaps, staff messaging, and certified Workday integration, and is marketed to healthcare organizations across the United States.

1 investor

Shmoody is a mobile app for self-care and mental health that guides users to take real-world mood-improving actions through an intentionally fun, science-backed experience. It also offers Shmoody U, a version for colleges and universities to support students.

1 investor

Shmoody is a mobile app that combines mental health support with accessible, engaging tools designed to encourage users to take actionable steps toward improved wellbeing. The platform targets students and college populations by making mental health tools feel relatable and enjoyable rather than clinical.

1 investor

SHOEBOX is a tablet-based audiometry platform that conducts hearing assessments on mobile devices; it has been clinically validated across multiple studies for use in various settings including clinics, schools, and remote locations.

1 investor

Sholder provides one-to-one transformational mental wellness sessions through trained community providers who use active listening and reflective questioning to help individuals reconnect with their inner wisdom. The service offers an alternative approach to traditional counseling and coaching, targeting people seeking mental well-being support.

1 investor

A psychedelics research organization that discovers new psychoactive substances and develops compounds and delivery systems for therapeutic use, continuing the work of Dr. Alexander "Sasha" Shulgin. It also operates as an educational organization in the field of psychedelics.

1 investor

Shuwen Biotech develops molecular and immunodiagnostic products for women's health, including breast cancer subtyping kits, nucleic acid extraction systems, and point-of-care tests for pregnancy complications. The company serves healthcare providers and pharmaceutical clients in clinical diagnostics and personalized medicine.

1 investor

A medical technology company developing innovative healthcare products including glucose monitoring and AI-powered retinal screening solutions, serving consumers and healthcare professionals.

1 investor

SideBy Care provides virtual care services for patients with Disorders of Gut-Brain Interaction (DGBI) including IBS and other digestive issues, working alongside healthcare providers to offer specialized support from mind-gut specialists, dietitians, and care advocates. The service integrates into existing medical practices as a new revenue stream while improving patient outcomes and satisfaction.

1 investor

Sidekick develops digital therapeutics (DTx) programs for people with chronic conditions such as oncology, cardiovascular, metabolic, and inflammatory diseases, using gamification, behavioral psychology, and behavioral economics to improve health outcomes. Its Adaptive Care Paths combine multiple programs to support patients living with multiple chronic conditions.

1 investor

SiDLY builds medical wearable wristbands with SOS, GPS and vital-sign sensors, paired with a mobile app and web platform for real-time patient monitoring, caregiver coordination and emergency response. Its AI-supported system serves patients, caregivers and medical tele-centers, and the products are designed and manufactured in Poland.

1 investor

Sierra Labs provides software to automate compliance and quality management processes for life science teams, aiming to reduce the cost and effort of meeting regulatory standards. It focuses on integrating quality management with technology and building compliance programs in regulated environments.

1 investor

Siggy offers clinician-supervised, always-on AI therapy that combines daily check-ins, medication management, and goal tracking, with licensed psychiatrists reviewing and prescribing non-controlled psychiatric medications. The service serves individuals seeking mental health care and is available to U.S. residents, rolling out state by state.

1 investor

Hope and Healing Survivor Resource Center is a nonprofit organization providing services and support to survivors of abuse, with a focus on training and addressing abuse in older adults through federal grant funding.

1 investor

Signallamp Health (now Tellihealth) provides remotely-embedded chronic care management (CCM) services, employing U.S.-based RNs and LPNs who integrate with medical practices to manage care for patients with chronic conditions between office visits. It serves health systems and physician groups, billing through existing CMS CPT codes on a revenue-share basis.

1 investor

Signature Diagnostics develops noninvasive diagnostic and screening tools, including noninvasive prenatal screening (NIPS) and pharmacogenomic (PGx) testing, based on genomics research into women's reproductive and organ health. It operates SDxLabs, a CLIA-certified clinical lab offering these testing services.

1 investor

SignatureMD enables independent physicians to practice personalized, relationship-based medicine by handling administrative and operational aspects of their practices. The platform serves physicians seeking to maintain independence while delivering thoughtful patient care outside traditional healthcare systems.

1 investor

Doctolib Connect (formerly Siilo) is a secure messaging platform designed for healthcare professionals to communicate and coordinate patient care. The service offers both individual messenger and organization-tailored solutions with emphasis on data security and HIPAA compliance.

1 investor

Sikka Soft offers software for dental and medical practices that connects scheduling, insurance, payments, reviews, and reporting, and automates front-office follow-up on recalls, balances, and claims. It targets individual practices and DSOs (dental service organizations) seeking to standardize operations and improve production and collections.

1 investor