Digital Health Startups

Optain develops AI-enabled clinical support tools that analyze full-colour retinal images to screen for eye diseases and assess cardiovascular disease risk. Its offering combines a portable fundus camera with Software as a Medical Device, aimed at clinicians for non-invasive disease screening.

2 investors

OpticSurg is a healthcare software startup building mixed reality tools for surgical operations and frontline healthcare workers, with the goal of reducing complications and expanding provider capacity. It focuses on serving providers in vulnerable and underserved communities.

2 investors

Optimity provides an employee wellness platform that delivers personalized wellness activities, team challenges, and rewards to engage and retain talent at mid to large-sized companies. The platform tracks physical activity and wellness outcomes, demonstrating measurable ROI through reduced healthcare claims and improved employee wellbeing metrics.

2 investors

OPUM is a MedTech company developing medical device technologies, supported by software and hardware engineering teams. The page names its board, executive leadership, and technical team but gives limited detail on the specific product.

2 investors

Opus Genetics is a clinical-stage ophthalmic biopharmaceutical company developing therapies for inherited retinal diseases (IRDs) and other retinal and refractive disorders. It focuses on genetic medicine aimed at preserving and restoring vision for patients with rare eye conditions.

2 investors

Opus Medical provides personalized case management services for injured workers, matching clinical oversight to the severity of each injury. It supports workers and employers through the recovery process using clinical coordination and evidence-based practices, primarily in the workers' compensation context.

2 investors

Ora Medical supplies medical equipment including the Levity, a device for which they provide funding guidance and reimbursement resources to help patients navigate insurance coverage and alternative financing options.

2 investors

Oral Genome offers a saliva-based, point-of-care testing platform that uses a smartphone app to analyze a test card and identify oral and whole-body health risk indicators within minutes. It is designed for dental, medical, institutional, and individual use across clinical, public-health, and community settings.

2 investors

OraLiva develops an AI-powered, non-invasive oral cancer test designed to detect cancer early during routine dental visits, using single-cell analysis and microfluidic technologies. The company is advancing a point-of-care diagnostic device for dental networks, building on its current lab-developed platform.

2 investors

Orbita provides AI-driven patient engagement and communication software that automates workflows across the care journey, including scheduling, intake, procedure prep, and follow-up. It serves healthcare organizations, aiming to increase patient engagement and reduce staff workload.

2 investors

Origin Sciences applies a hologenomic approach integrating host genetics, epigenetics, and microbiome analysis into a single diagnostic framework for deeper health assessment. The company works with leading institutions and technology providers to develop and scale advanced diagnostic assays for clinical and research applications.

2 investors

OrisDX develops a non-invasive salivary-rinse DNA test called Oro Lesion to detect early markers of oral cavity squamous cell carcinoma in adults with indeterminate oral lesions. It pairs the test with Oris Bridge, a digital health patient navigator that handles clinical referrals, patient education, and medical claim automation and review.

2 investors

Orthoforge provides a diagnostic system using ultrasonic analysis and proprietary algorithms to quantify bone and soft tissue healing after injury, delivered through telemedicine without radiation exposure. The technology targets clinicians and orthopedic patients seeking objective, real-time monitoring of fracture recovery.

2 investors

Oska Health provides continuous care management for people with chronic kidney disease, aiming to reduce complications, hospitalizations, and healthcare costs through integrated digital and clinical support.

2 investors

Otos is a platform that combines hearing and cognitive health assessment into a single system, with automated testing, triage, and continuous patient monitoring for integration into clinical workflows. It serves health systems, ENT and audiology practices, primary care, neurology, and longevity clinics, and is running clinical validation and pilot programs in Europe and the U.S.

2 investors

OTTAA Project is a mobile augmentative and alternative communication (AAC) system for people with speech disabilities, letting users build phrases from internationally recognized pictograms. The tool is customizable, supports multiple languages, and includes accessibility features for users with motor impairments such as hemiplegia, spasticity, cerebral palsy, or stroke.

2 investors

Ourry Medical is a healthcare company focused on integrating and improving expertise centered on patient outcomes, combining technology and human expertise to deliver comprehensive solutions for healthcare needs.

2 investors

OutcomeMD operates a data network that collects patient-reported outcome measures (PROMs) from clinicians and transforms them into insights for providers, health systems, and researchers. The platform serves healthcare providers, practice groups, biopharma companies, and researchers seeking to improve patient outcomes and access real-world clinical data.

2 investors

Outfox Health uses AI tools to help American workers and employers reduce healthcare costs by providing transparency and information about healthcare pricing, delivery, and outcomes. The company addresses the information asymmetry in the U.S. healthcare system that has driven costs to over 10% of household income.

2 investors

Owlstone Medical develops a breath-based diagnostic platform for non-invasive disease detection across respiratory conditions, cancers, and digestive health. The company serves academic, clinical, and pharmaceutical research partners seeking to develop breath biomarker applications for precision medicine and early diagnosis.

2 investors

Oxford Brain Diagnostics provides CDM Insights, a clinical software platform that analyzes MRI scans to detect and monitor microstructural changes in the brain for early diagnosis of neurodegenerative conditions. The platform integrates with standard hospital MRI systems and delivers quantitative brain assessment reports to clinicians within 12 hours.

2 investors

Oxford Medical Simulation (OMS) provides immersive VR and AI-based clinical training scenarios for healthcare professionals and learners. Founded by clinicians, the platform aims to make clinical readiness measurable and repeatable for healthcare education organizations.

2 investors

Play Health builds a clinical decision-support platform for healthcare providers to deliver personalized menopause and women's health care. The platform serves primary care physicians and other providers treating women navigating perimenopause and menopause.

2 investors

Pairidex offers FusionMRD, a personalized digital droplet PCR (ddPCR) assay that detects and quantifies oncogenic gene fusions from a standard peripheral blood sample to monitor treatment response and minimal residual disease in gene fusion-driven blood cancers such as leukemia. It is sold as a commercial service for oncologists and clinical researchers to support treatment decisions and shorten clinical trial timelines.

2 investors