Deep Tech Startups

Olam Labs builds multiplayer game environments — such as no-limit Texas hold'em, Risk-style conquest, Codenames-style word deduction, and market simulations — to study how AI agents negotiate, socialize, and compete alongside humans. It also runs large-scale internal simulations with hundreds of concurrent agents and publishes notable research runs.

4 investors

Olive develops machine learning and signal processing technology with applications across education, mobility, and healthcare sectors. The company combines expertise in ML, signal processing, and biomedical engineering to deliver field-tested solutions.

4 investors

OMass is a biotech company that originated as a spinout from Oxford University, developing specialized treatments for patient populations with high unmet medical needs. The company builds integrated development and commercialization capabilities while partnering to advance programs addressing large indications.

4 investors

Onava is a drug discovery company that combines AI-native protein engineering, autonomous orchestration of model training and experimental feedback, and high-throughput functional assays to develop next-generation therapeutics. Its platform uses a cross-program data flywheel where insights from each program inform future candidate optimization.

4 investors

Oncko develops machine learning and experimental platforms to discover optimized multi-drug cancer treatment combinations by screening against resistance mechanisms. The company serves oncology drug developers seeking to identify efficacious combination regimens for cancer indications.

4 investors

Ophidion is a biotechnology company developing therapeutics based on the cholinergic system and lynx gene modulators, which regulate nicotinic acetylcholine receptors. Its drug discovery programs target neurological and related conditions, including an early small-molecule smoking cessation candidate and peptide/protein programs.

4 investors

Opsys develops solid-state scanning LiDAR sensors with no moving parts, using VCSEL and SPAD chip technology for autonomous driving and industrial applications.

4 investors

Opt Industries engineers advanced materials using digital photolithography to create structured materials with precise microstructure control, enabling functional properties across applications from high-speed interconnects to fluid handling.

4 investors

Optalysys is a photonic computing company using silicon photonics to turn the optical layer into an arithmetic engine for high-performance computing. It targets applications in AI, security, and scientific discovery, aiming to overcome the data movement bottleneck of conventional electronic systems.

4 investors

Opteran develops autonomy software for robots and machines by reverse-engineering neural algorithms from insect brains, using computational neuroscience rather than deep learning. The company applies these "natural intelligence" principles to create autonomous systems that operate efficiently without network connectivity for robotics and drone applications.

4 investors

Orbit Discovery provides peptide discovery solutions for pharmaceutical and biotechnology companies, serving both large pharmaceutical firms and smaller biotech enterprises.

4 investors

Orbital Composites develops composite materials and structures for aerospace applications, including the STARFIGHTER X modular drone platform designed for efficient flight across various regimes and speeds.

4 investors

Orbital Matter designs and builds large rigid structures directly in orbit as an alternative to mechanical folding/deployable systems, targeting large-area elements such as solar arrays, radiators and antennas for satellite constellations, space data centers and multi-module space stations. Its approach constructs continuous monolithic booms in space rather than launching pre-folded hardware.

4 investors

Orchard Therapeutics develops ex vivo autologous hematopoietic stem cell (HSC) gene therapies for genetic and other severe diseases, including rare inherited conditions such as ADA-SCID and metachromatic leukodystrophy. The Nasdaq-listed biotech (ticker ORTX) has commercialized therapies including Strimvelis and Libmeldy in Europe.

4 investors

Ordaōs uses AI and deep learning through its Design Engine to design novel mini-proteins and protein binders such as nanobodies for drug discovery. The company serves pharmaceutical and biologics researchers, combining generative machine-learning models with wet-lab protein expression and characterization.

4 investors

Ossia develops and licenses Cota, an RF-based wireless power technology that delivers targeted energy to devices at a distance without pads or contact-based charging, along with receivers, transmitters, and cloud software. The company licenses its technology to OEMs worldwide serving the wireless power ecosystem.

4 investors

OTIV develops assisted, remote-control, and autonomous technology for rail freight operations to improve safety and efficiency while reducing carbon emissions and congestion. The company targets freight transportation operators seeking modal shift solutions from road to rail.

4 investors

Ouros Energy is an American battery company that controls the full stack from mineral sourcing and cell chemistry through cell manufacturing and delivery. It develops active materials, cylindrical and pouch cells, and domestic production capability for defense and civilian markets.

4 investors

An open science laboratory focused on developing world models through decentralized research and collaboration across diverse perspectives.

4 investors

Owl AI develops image sensing technology, with expertise spanning low-noise imaging, data converters, and hardware DSP for applications in the automotive, consumer electronics, and defense markets.

4 investors

Oxford Quantum Circuits (OQC) develops and operates superconducting quantum computers for commercial and strategic applications, offering Quantum-Compute-as-a-Service and integrating quantum systems directly into commercial data centres. It serves enterprise customers with deployments across the UK, US, Japan, and Spain.

4 investors

Oxipital AI builds AI-based machine vision technology, including its V-CORTX platform, cameras, and no-code dashboards, for inspection and vision-guided robotics applications. It targets machine builders and manufacturers, with a focus on food, agriculture, and other high-variability production environments.

4 investors

A tech startup operating in stealth mode on an undisclosed vision; it has developed Veluminum, a matte, velvet-like coating for aluminum.

4 investors

Palabra.ai provides an AI bot that adds real-time voice translation and captions to Microsoft Teams meetings, supporting 60+ languages with sub-1-second latency. It targets businesses running multilingual meetings, webinars, and vendor or customer calls, and offers custom glossaries and private cloud or on-premises deployment for enterprise customers.

4 investors