Deep Tech Startups

RedactBio is a biotechnology company working at the intersection of gene editing and tissue engineering.

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ReElement develops purification and separation technology for refining critical minerals into high-purity materials at low cost. The company operates globally with a focus on deploying its technology platform in mineral-rich African nations to support local advanced manufacturing.

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RenBio develops DNA-based therapeutic technology that uses intramuscular injection of therapeutic-encoding "bioblueprints" so a patient's own muscle cells produce antibodies and therapeutic proteins to prevent and treat diseases, including infectious diseases. The company works in the antibody and therapeutic protein field, aiming to overcome obstacles in delivery, durability, and cost.

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Renue Life Sciences develops next-generation therapies for age-related and complex diseases, working in areas such as cell and gene therapy, RNA therapeutics, and CRISPR-based approaches. The company targets researchers, partners, and investors in the biotech and longevity space.

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Replicate Bioscience develops self-replicating RNA (srRNA) vector therapeutics that use cells' own machinery to produce sustained protein expression, aiming for durable therapeutic effects. Its pipeline targets several therapeutic areas including infectious disease, oncology, and autoimmune disorders.

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Reverse Ionizer develops patented water treatment technologies for commercial and industrial applications. Its Plasma Disinfection System uses non-thermal plasma to control pathogens in cooling towers and water systems, while its electromagnetic ExB technology addresses scale and corrosion in desalination plants.

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Revitope Oncology is a biotechnology company developing precision cancer immunotherapies using its TwoGATE T cell engager platform, which uses paired tumor-targeted bispecific antibodies that become active only on cancer cells co-expressing two antigens to limit toxicity to healthy tissue. Its pipeline focuses on solid tumor indications, developed in-house and through partnerships with companies such as Genmab and Junshi Biosciences.

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Rezonent designs low-power semiconductor solutions, including SRAMs and AI/ML inference circuits on advanced FinFET nodes. The company focuses on chip design for power management and high-performance computing markets.

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Redwire is an integrated aerospace and defense company that develops space infrastructure, autonomous aircraft, and multi-domain defense technologies for the U.S. and allied militaries, as well as commercial and government space programs. Its work spans satellite platforms, uncrewed aerial systems, space-enabled R&D and manufacturing, and in-space pharmaceutical development.

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RtBrick provides carrier-grade routing software that runs on white-box hardware, letting telecom operators build disaggregated IP networks including broadband network gateways (BNG). It serves network operators and service providers using software-defined networking to separate hardware from network software.

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SAAZ develops advanced imaging sensors and cameras for military, space, and commercial applications, with technology spanning visible, infrared, and ultraviolet detection. The company provides mission-ready sensor solutions for space, airborne, and defense customers.

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SafetySpect develops miniaturized multimode spectroscopy systems powered by sensor hardware and AI/machine learning to detect hygiene and health risks across industries. Products are designed and manufactured in the USA.

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Salus Scientific designs radiation protection solutions for healthcare providers, with a focus on eliminating occupational hazards in fluoroscopy and medical environments. The company's flagship product addresses the physical strain caused by traditional lead aprons used in medical imaging procedures.

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Evaratus (formerly Scaler AI Labs) partners with frontier AI companies to support model training through high-fidelity reinforcement learning environments, expert-curated datasets, and a network of vetted technical talent. It also builds benchmarks for measuring AI performance on real-world tasks, such as project management work across tools like Linear and Jira.

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Schematic provides formal verification for software and AI systems, using deterministic mathematical checks to prove whether a system always meets stated requirements or to return the exact input that breaks the claim. It serves software assurance and regulatory assurance use cases, turning unit tests, expected behaviors, policies, and requirements into guarantees covering every possible input.

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Scientific Lightning Solutions provides lightning monitoring systems, risk assessments, protection system design, inspections, and forensic investigations to help critical facilities mitigate lightning-related risks. The company serves industries requiring lightning safety and operational resilience.

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Scout is a mineral exploration company focused on identifying copper and gold deposits in Idaho. The company operates as a discovery generator, conducting drilling and resource assessment on a portfolio of projects before partnering with operators to develop commercial mines.

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Thermal designs and manufactures thermal imaging sensors, cores, and components for firefighting, industrial monitoring, and OEM integration. It operates a fabless semiconductor model with U.S.-based design and manufacturing.

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Sentiré Medical Systems develops gas sensing technology for minimally invasive surgery that provides surgeons with additional intraoperative information. The SENSai platform integrates chemical sensing capabilities into operating room workflows to enhance surgical awareness and efficiency.

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Sequome uses AI to engineer biological sequences for developing therapeutics, based on its sequence-to-function model called Gene Genie. The company has collaborated with large pharmaceutical firms and Google DeepMind in the drug discovery and biotechnology space.

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seqWell develops reagents and technologies for next-generation sequencing library preparation, serving academic and institutional research clients. The company's proprietary plexWell platform enables researchers to streamline NGS workflows.

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Seranova is a biotech company that combines REAP autoantibody profiling with clinically linked patient cohorts to identify naturally occurring protective autoantibodies against specific extracellular targets and translate those protective associations into therapeutic hypotheses. Its approach treats protective autoantibodies as long-duration human perturbations linked to clinical outcomes for drug discovery.

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Sethera Therapeutics develops peptide-based therapeutics using innovative enzyme chemistry research. The company focuses on commercializing novel peptide drugs derived from breakthrough scientific discoveries.

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Silver Creek develops growth factor-based therapeutics to promote cell survival and growth in response to injury. The company focuses on rescuing damaged cells through targeted biologic interventions.

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