Deep Tech Startups

CoFlo Medical develops a drug-delivery platform based on core annular flow, which surrounds a viscous drug with a thin low-viscosity fluid so ultra-high-concentration biologics can be injected through fine needles at low force. Its CO-AXL hub adapts any primary container to enable at-home injection of highly viscous formulations (up to 400 mg/mL and over 1,000 cP), serving pharmaceutical developers and patients.

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Cognixion develops non-invasive brain-computer interfaces and adaptive assistive technology that provide communication and control for people with complex disabilities. Its multimodal systems combine intent, context, and accessible spatial computing across interfaces such as the Apple Vision Pro.

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Colibri Resource Corp is a precious metals exploration company focused on developing gold projects in Sonora, Mexico. The company operates over 7,000 hectares of mineral-rich claims with three active joint venture partners to identify bulk tonnage opportunities in one of the world's historically significant mining regions.

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Collidion is a healthcare holding company that develops, acquires, and licenses novel assets in healthcare, supporting program-focused subsidiaries with capital, operational support, and IP. Its subsidiaries include Spectrum Antimicrobials, which develops anti-infective, disinfection, and sterilization technologies, and Plex Pharmaceuticals, which targets complex diseases such as Parkinson's, glioblastoma, and cataracts.

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Collision Communications develops advanced signal processing technology for mobile networks, specifically interference-aware receivers and channel estimation for LTE communications to improve spectral efficiency and network performance.

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Columbus Photovoltaics develops an ultra-thin add-on layer that is applied on top of existing silicon solar cells to absorb more of the solar spectrum and increase efficiency using low-cost semiconductor materials. The company targets applications including mobile devices, electric vehicles, IoT, drones, military, and residential and utility-scale solar, and plans to license its patented technology to solar and electronics manufacturers.</parameter> <parameter name="founders">[]

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Comhear develops AI-enabled adaptive audio technology that uses sensors to assess a listener's environment and position in real time, beaming personalized sound directly to individuals. Its technology targets applications including kiosks, hospitality, automotive, retail merchandising, gaming, virtual/augmented reality, and home entertainment.

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Consolidated Resource Imaging provides imaging solutions and custom-engineered systems built from high-quality components for specialized applications.

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Continuity Biosciences develops adaptive precision drug-delivery platforms that combine engineering and biology to help therapies reach their intended targets more effectively. The company works across multiple therapeutic applications rather than a single drug or disease, bridging medtech and biotech.

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Continuous Composites develops CF3D, a continuous fiber additive manufacturing technology for producing high-performance composite parts and resin systems. It serves aerospace, defense, and high-temperature applications, including national security work.

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Cosmoserve Space develops Active Debris Removal (ADR) technology using its proprietary "Reviver" and "Mothercraft" spacecraft to capture and de-orbit orbital debris and non-operational satellites. It provides commercial de-orbiting and debris removal services to satellite constellation operators and government space agencies.

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CQens designs devices and methods that heat plant-based and medicant-infused formulations to produce aerosols for inhalation, with a focus on harm reduction. The company operates in Nevada and California, holding a portfolio of 111 US and international patents.

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Critical Frequency Design delivers mission-critical engineering and manufacturing solutions for defense acquisition projects, leveraging deep expertise in supply chain and program management. The company serves defense agencies and prime contractors from its base in Florida's Space Coast region.

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Cuprum Metals develops a patented leaching technology for extracting copper and nickel from copper sulfide ores and tailings, achieving high recovery yields in minutes at room temperature. The process is aimed at mining operators and can be integrated into existing heap, vat, or agitation leaching systems with lower water and energy use.

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Cyber Advanced Technology (CAT) builds an alternative network and computing infrastructure called OT-OCN, along with hardware appliances, an AI framework (CAT AI-ONE), the WebChain blockchain, and cybersecurity systems for smart cities, national defense, energy, and financial infrastructure. Its products aim to provide immune-layer security, real-time deterministic processing, and DePIN-ready sovereign infrastructure.

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Decision Sciences Corp develops imaging technology for port-of-entry security that scans cargo to distinguish legitimate shipments from concealed contraband and detect hidden threats.

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Deep Apple Therapeutics is discovering small-molecule drug candidates using cryo-EM structural biology, artificial intelligence, and virtual screening to identify compounds for various diseases. The company serves pharmaceutical development and biomedical research.

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Diametryx develops color-changing micro- and nano-scale particles that can be deployed in ink or film, using new actuation mechanisms and compositions. The company works in advanced materials, offering particles capable of rapid color changes across a broad color palette.

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Digital Global Systems develops RF (radio frequency) analysis and autonomous sensing software for spectrum optimization and threat detection in critical infrastructure environments.

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Dimer Instruments develops high-performance scientific instruments for biopharmaceutical analysis, using light scattering and biophysical characterization technologies to accelerate drug development processes. The company serves pharmaceutical researchers and drug development teams.

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Double Helix Optics develops 3D imaging and sensing technology for scientific microscopy, based on its engineered point spread function (ePSF) and Nobel Prize-winning super-resolution methods. Its SPINDLE modules, phase masks, and 3DTRAX software attach to existing microscopes to capture instantaneous nanoscale 3D data for researchers in spatial biology and life sciences.

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Droplet Measurement Technologies designs and manufactures scientific instruments and airborne probes for researchers studying atmospheric and cloud physics across global research institutions.

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Dualitas Therapeutics develops bispecific antibody therapies that pair a proprietary proximity engager arm with an antibody against a therapeutic target, using its DualScreen discovery engine to identify synergistic target combinations. Its pipeline targets autoimmune, allergic, and other immune and inflammatory diseases, with lead candidate DTX-102 for rheumatoid arthritis in IND-enabling studies.

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ECM designs custom printed circuit board stator motors for robotic applications, offering significant reductions in weight and axial length compared to conventional catalog servo motors. The motors feature zero cogging torque, high peak torque, and precise controllability, serving robotics OEMs developing collaborative robots, surgical robots, and multi-joint systems.

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