Deep Tech Startups

Unleash BTS provides operations support, advanced engineering, and research & development services to the U.S. Department of Defense and Intelligence Community, including cyber analysis, counter-unmanned systems, cloud computing, and AI/ML applications for national security missions.

1 investor

Unobio is a biotech company running drug discovery programs that begin with patient data and validate candidates against patient biology at each stage, aiming to improve translation rates from preclinical work to clinical trials. Its approach targets the failure of programs that clear in vitro and animal models but fail in later-stage clinical phases.

1 investor

Unreasonable Labs builds an AI discovery engine that integrates data across physics, biology, chemistry, materials, and markets to form theory-like abstractions, generate hypotheses, and produce cross-domain insights. It targets academic and government scientists, industrial R&D teams, and corporate strategy groups seeking an AI collaborator for research and discovery.

1 investor

Unruly Capital is an early-stage venture capital firm investing in frontier technology, climate, crypto, and biotech. It backs founders working on ideas around depopulation, decentralization, new sovereigns, and peptide therapeutics.

1 investor

Unto Labs builds Thru, a base-layer blockchain that applies high-performance computing principles to distributed systems for scalability and performance. The company targets developers building on its blockchain platform.

1 investor

Institute of Organic Chemistry and Biochemistry (IOCB) is a research institution under the Czech Academy of Sciences conducting basic research at the intersection of chemistry, biology, and computational sciences, with a systematic infrastructure for translating scientific discoveries into commercial products and technologies.

1 investor

The University of Manchester's technology transfer office that commercializes academic research and intellectual property through spinout creation and licensing arrangements. It works with university inventors to identify and develop innovations for societal impact.

1 investor

UOR Foundation develops the UOR Framework, a computational substrate for agentic AI that assigns each object a content-derived address to provide persistent identity, trustless verification, and composability. It aims to structurally address issues such as identity fraud, authentication exploits, prompt injection, and spam in AI agent systems.

1 investor

Upnano develops specialized photoresins for two-photon polymerization printing, enabling high-resolution manufacturing of micro- and nanoscale parts with complex geometries. The company serves precision manufacturing and microstructure fabrication markets requiring intricate 3D details and free-floating elements.

1 investor

A company offering a managed model service (USF Series) that provides domain-specialized, right-sized AI models deployed on-premise, aimed at reducing the cost of running inference compared to per-token cloud API pricing.

1 investor

Dynamic Map Platform (DMP) North America is a geospatial measurement and software company that produces high-definition maps and road data for advanced driver assistance, semi-autonomous, and autonomous driving applications. It also supplies high-precision road data for government, transportation, and smart city infrastructure projects across the US, Canada, Japan, South Korea, and Western Europe.

1 investor

UTVate (rebranded as Farcast) designs satellite internet user terminals, building flat panel antennas with phased array technology and electronically scanned beams for GEO and LEO satellite systems. Its terminals serve moving users such as cars and airplanes, reducing size, weight, power, and cost for satellite communications.

1 investor

Uviquity develops photonic integrated circuits built on aluminum nitride that generate and convert light across wavelengths from deep ultraviolet through infrared on a single wafer-scale chip. Its light-engine chips target quantum computing, advanced sensing, and human-safe ultraviolet disinfection applications.

1 investor

UXN develops non-enzymatic blood glucose sensors based on nanoporous platinum electrodes, using electrochemical and biosensor technology for continuous, blood-draw-free glucose monitoring. The company also researches implantable glucose measurement technology for healthcare applications.

1 investor

V-Labs provides augmented reality glasses with GNSS/RTK positioning for field work, enabling surveyors, contractors, and utilities to visualize and measure geospatial data with centimeter accuracy. The platform integrates work instructions and remote assistance to optimize field operations for utilities, railways, and construction contractors.

1 investor

Vail Scientific develops VSNO, a non-invasive, point-of-care diagnostic tool for rapid screening of patients suspected of having sepsis to aid in triage. The company serves healthcare providers with medical technology aimed at earlier sepsis diagnosis.

1 investor

Valcare Medical develops transcatheter solutions for treating mitral regurgitation, a structural heart condition, aiming to provide surgical-level durability without open-heart surgery. The company's flagship system is designed for interventional cardiologists and patients requiring mitral valve repair.

1 investor

Valen designs drugs using computational biology and experimental data generation. The company serves pharmaceutical and biotech researchers developing the next generation of therapeutics.

1 investor

Valence builds an emotional communication layer for AI systems, aiming to give them functional emotional understanding by modeling not just intent but impact. The company focuses on AI alignment through emotionally intelligent, transparent, and human-guided technology.

1 investor

Valgotech designs lithium-sulfur battery cells for defense and aerospace platforms, focusing on energy density, thermal safety, and supply chain independence from conflict minerals. The company serves defense primes, UAV manufacturers, and aerospace integrators.

1 investor

Valiant Space develops non-toxic satellite propulsion systems, including the VS-1 thruster that uses nitrous oxide and propane instead of hydrazine to deliver high-thrust orbit raising and collision avoidance manoeuvres. It targets satellite operators seeking lower-cost propulsion in the space industry.

1 investor

VALID builds human iPSC-derived co-culture disease models and pairs them with automated high-throughput perturbation screening and multimodal measurement (imaging, RNA-seq, proteomics) to generate AI-ready biological data for drug discovery. Its platform aims to produce more human-relevant, predictive hypotheses and targets for pharmaceutical development.

1 investor

ValleyDAO provides funding and community support to research scientists and entrepreneurs developing unconventional biotech projects, offering grants up to $250k with rapid turnaround and access to a network of investors and thought leaders.

1 investor

Valor develops proprietary electrochemical separations technology (redox-mediated liquid–liquid extraction) that upgrades metallurgical intermediates from mining and recycling supply chains into higher-value metals and materials. It targets domestic critical minerals processing and refining in the United States, integrating with existing commercial mining and recycling equipment.

1 investor