Deep Tech Startups

Sidewalk Infrastructure Partners (SIP) invests in and develops businesses and projects focused on energy and digital infrastructure systems, including virtual power plants and data centers. Its portfolio includes Renew Home, an operator of residential virtual power plants, and Verrus, a data center developer.

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Silver Creek develops growth factor-based therapeutics to promote cell survival and growth in response to injury. The company focuses on rescuing damaged cells through targeted biologic interventions.

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Silver47 is a silver exploration and production company focused on developing critical mineral assets in the United States. The company operates projects in Alaska and New Mexico with the goal of reducing U.S. dependence on foreign silver imports and supporting domestic supply chain security.

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Simnovus develops simulation and emulation tools for validating 5G radio access networks, serving telecommunications and network operators through software-based testing platforms.

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SiVEC Biotechnologies develops BactPac, a live biotherapeutic delivery platform that enables targeted delivery of nucleic acid therapies and gene editing therapies for clinical advancement. The company licenses its platform technology to pharmaceutical partners and pursues its own therapeutic pipeline in oncology and other disease areas.

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Soarce is a dual-use advanced materials company that produces tunable nanocellulose nanofiber additives from biomass, using a proprietary cellulose treatment process that functionalizes fibers at industrial scale. Its coatings and additives strengthen composites (carbon fiber, fiberglass, kevlar) and serve commodity industries such as agriculture, cement, and paper for industrial manufacturers.

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Sofab manufactures nanoparticle products, developed from research at the University of Louisville's Conn Center for Renewable Energy Research with U.S. Department of Energy support. The company serves industries requiring advanced materials with improved cost efficiency and manufacturing flexibility.

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Sókn Engineering develops proprietary forecasting models and pricing technology for commodities, real-world assets, and financial instruments, serving hedge funds, trading desks, and other entities involved in commodities pricing and trading. The company's mathematical models forecast price movements and measure pricing pressures across virtually all commodities and financial instruments.

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A neuroscience company developing medical solutions based on brain imaging and neurological research for clinical and research applications.

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Spectral Platforms develops imaging and sensing technologies based on optical and materials science innovations. The company was founded by Ravi Verma, a materials scientist with expertise in optics and MEMS, and is supported by a board of distinguished scientists and industry leaders.

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Spheryx develops Total Holographic Characterization technology for analyzing suspensions at the sub-visible particle level, including detecting protein aggregates and particles in biopharmaceuticals. Its analytical tools serve product development, manufacturing, and quality assurance across industries such as pharmaceuticals, cosmetics, chemicals, industrial fluids, and petroleum products.

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Spinogenix is a biopharmaceutical company developing therapies to restore synaptic function, with a pipeline aimed at neurological and neurodegenerative conditions.

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Starfighters Space operates a fleet of F-104 Starfighter jets capable of flying at Mach 2 to launch payloads into space. The company provides commercial air-launch space services and is pursuing an FAA launch license.

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Summit Venture Studio is a venture studio that creates and commercializes technology companies, particularly those spun out from university intellectual property and research. The firm works with academic institutions to develop and scale early-stage technology ventures.

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Surface Design Solutions offers Surface Designer, a physics-informed AI software platform paired with expert analysis services that help manufacturers optimize the surfaces of parts and tooling. It serves industries such as automotive, aerospace and defense, medical devices, semiconductors, additive manufacturing, and consumer electronics to reduce costs, improve quality, and stabilize production.

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Sus Clinicals provides preclinical testing services using its Oncopig cancer model, a large-animal platform that induces tumors and other diseases on demand to generate predictive data for medical devices, drugs, and diagnostics. It serves healthcare and therapeutics developers seeking to accelerate drug and device development toward clinical trials.

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Swift Coat develops nanomaterial spray coating technology called Aerosol Impact Driven Assembly (AIDA) for integrating nanomaterials into large-area, high-volume manufacturing. Its coatings are applied to products in fields such as solar energy modules and spacecraft components.

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Synata Bio develops customizable technology solutions for hydrogen and carbon economies, enabling hard-to-abate industries to achieve decarbonization targets while reducing carbon emissions and creating value from waste resources.

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SynthBee is developing "Collaborative Intelligence," technology aimed at combining human and computer work to tackle scientific, engineering, design, and creative problems.

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Syrna Therapeutics is a biotech company developing small-molecule covalent translation inhibitors that bind and modify structured domains in the mRNA of disease-causing proteins to block their expression. It uses a 3D structure-guided drug discovery platform, with lead programs in immunology and neurodegeneration and a broader pipeline spanning metabolic disease and oncology.

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Tactual Labs develops technology for human-computer interaction and near-range RF (radio frequency) field applications. The company creates systems and devices that enable machines to sense and respond to human presence and interaction.

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Tamarack Aero develops Active Winglet and SMARTWING technology for aircraft, serving business, military, and commercial aviation. It also offers in-flight connectivity, aircraft engineering consulting, and warranty support services.

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Tangram Flex provides an assured integration pipeline for defense systems, turning sources of truth (MBSE models, ICDs, requirements) into verifiable behavioral specifications using its open Flex language and Tangram Pro tool suite. Its products and services help defense programs, integrators, and vendors verify component integration, prove standards compliance (FACE, SOSA, UCI, GRA, WOSA, UAI), and translate protocols at the tactical edge.

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Taranis Resources is a Canadian mineral exploration company focused on advancing the Thor polymetallic deposit in southeastern British Columbia through science-driven exploration techniques. The company specializes in revitalizing historic mining districts by integrating legacy data with modern geophysics, drilling, and 3D modeling to uncover mineral potential.

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