Deep Tech Startups

Rampart Communications develops secure wireless communication technology based on Unitary Braid Division Multiplexing (UBDM), a signal processing and information theory approach to communications security. It holds patents and partners with organizations across industries to build secure wireless systems for individuals, businesses, and governments.

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Rare Earth Technologies, Inc. (RETi) refines and separates rare-earth elements using a proprietary column-chemistry system that produces oxides or carbonates at up to 99.999% purity with non-toxic solvents. The company serves the REE materials supply chain and plans to open its first US refining facility in 2025.

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Red Leader develops signal processing IP, integrated ADC/DAC silicon, and end-to-end systems for 3D lidar sensing, using full-waveform processing to improve resolution, range, and accuracy of low-cost sensors without added hardware. Its technology targets safety-critical applications requiring high-speed, low-latency 3D data.

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Red Team Investments (RTI) is an investment firm that applies a "Red Team" adversarial evaluation approach to identify macro market trends and investment opportunities, drawing on experience across the energy, data, technology, and investment sectors. The firm also plans to build regional data centers to provide AI compute and data storage for its portfolio companies and customers.

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RedactBio is a biotechnology company working at the intersection of gene editing and tissue engineering.

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ReElement develops purification and separation technology for refining critical minerals into high-purity materials at low cost. The company operates globally with a focus on deploying its technology platform in mineral-rich African nations to support local advanced manufacturing.

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RenBio develops DNA-based therapeutic technology that uses intramuscular injection of therapeutic-encoding "bioblueprints" so a patient's own muscle cells produce antibodies and therapeutic proteins to prevent and treat diseases, including infectious diseases. The company works in the antibody and therapeutic protein field, aiming to overcome obstacles in delivery, durability, and cost.

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Renerva develops implantable medical devices to treat peripheral nerve injuries. The company was founded from academic research at the University of Pittsburgh and Cornell University.

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Replicate Bioscience develops self-replicating RNA (srRNA) vector therapeutics that use cells' own machinery to produce sustained protein expression, aiming for durable therapeutic effects. Its pipeline targets several therapeutic areas including infectious disease, oncology, and autoimmune disorders.

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Revel Pharmaceuticals develops enzyme-based therapeutics designed to recognize and reverse molecular damage that accumulates in the body's structural tissue — collagen, elastin, and extracellular matrix — targeting age-related damage that drives disease. The company screens natural enzyme variants against real substrates to identify and engineer them into treatments.

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Reverse Ionizer develops patented water treatment technologies for commercial and industrial applications. Its Plasma Disinfection System uses non-thermal plasma to control pathogens in cooling towers and water systems, while its electromagnetic ExB technology addresses scale and corrosion in desalination plants.

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Revitope Oncology is a biotechnology company developing precision cancer immunotherapies using its TwoGATE T cell engager platform, which uses paired tumor-targeted bispecific antibodies that become active only on cancer cells co-expressing two antigens to limit toxicity to healthy tissue. Its pipeline focuses on solid tumor indications, developed in-house and through partnerships with companies such as Genmab and Junshi Biosciences.

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Rezonent designs low-power semiconductor solutions, including SRAMs and AI/ML inference circuits on advanced FinFET nodes. The company focuses on chip design for power management and high-performance computing markets.

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Redwire is an integrated aerospace and defense company that develops space infrastructure, autonomous aircraft, and multi-domain defense technologies for the U.S. and allied militaries, as well as commercial and government space programs. Its work spans satellite platforms, uncrewed aerial systems, space-enabled R&D and manufacturing, and in-space pharmaceutical development.

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RtBrick provides carrier-grade routing software that runs on white-box hardware, letting telecom operators build disaggregated IP networks including broadband network gateways (BNG). It serves network operators and service providers using software-defined networking to separate hardware from network software.

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Saluda Medical develops the Evoke spinal cord stimulation (SCS) system, which records the spinal cord's physiologic response to stimulation using Evoked Compound Action Potentials (ECAPs). The company builds neuromodulation therapies for chronic pain management, serving healthcare providers and patients.

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Salus Scientific designs radiation protection solutions for healthcare providers, with a focus on eliminating occupational hazards in fluoroscopy and medical environments. The company's flagship product addresses the physical strain caused by traditional lead aprons used in medical imaging procedures.

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Evaratus (formerly Scaler AI Labs) partners with frontier AI companies to support model training through high-fidelity reinforcement learning environments, expert-curated datasets, and a network of vetted technical talent. It also builds benchmarks for measuring AI performance on real-world tasks, such as project management work across tools like Linear and Jira.

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Scientific Lightning Solutions provides lightning monitoring systems, risk assessments, protection system design, inspections, and forensic investigations to help critical facilities mitigate lightning-related risks. The company serves industries requiring lightning safety and operational resilience.

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Scout is a mineral exploration company focused on identifying copper and gold deposits in Idaho. The company operates as a discovery generator, conducting drilling and resource assessment on a portfolio of projects before partnering with operators to develop commercial mines.

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Sentiré Medical Systems develops gas sensing technology for minimally invasive surgery that provides surgeons with additional intraoperative information. The SENSai platform integrates chemical sensing capabilities into operating room workflows to enhance surgical awareness and efficiency.

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Sequome uses AI to engineer biological sequences for developing therapeutics, based on its sequence-to-function model called Gene Genie. The company has collaborated with large pharmaceutical firms and Google DeepMind in the drug discovery and biotechnology space.

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seqWell develops reagents and technologies for next-generation sequencing library preparation, serving academic and institutional research clients. The company's proprietary plexWell platform enables researchers to streamline NGS workflows.

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Sethera Therapeutics develops peptide-based therapeutics using innovative enzyme chemistry research. The company focuses on commercializing novel peptide drugs derived from breakthrough scientific discoveries.

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