Deep Tech Startups

Refractive Labs develops design tooling for silicon photonics, aiming to automate and accelerate the creation of photonic chips used in data center and AI compute interconnects. It targets the semiconductor and photonics industry, where optical links increasingly replace electrical interconnect for high-bandwidth, low-latency computing.

1 investor

Regenosca develops TissueSpan, an absorbable mesh implant that prompts the body to attract and organize its own cells for soft tissue regeneration, reinforcing or replacing damaged tissue. Its initial target application is urethral stricture repair, with potential use across a range of regenerative surgical interventions.

1 investor

Reliability Engine develops sensing and software that monitors liquid-cooled AI infrastructure by analyzing coolant chemistry, thermal systems, and GPU performance data to detect cooling issues before they impact compute output. The product serves AI data center operators managing high-density infrastructure.

1 investor

Reliance is an engineering company that researches, develops, and manufactures critical systems, components, and sub-assemblies for complex environments. It serves the defence, space, and life sciences sectors.

1 investor

Reloc develops jamming- and spoofing-resistant tactical navigation systems that fuse GNSS, IMU, and wheel odometry with manual heading corrections. Its hardware is built from European commercial off-the-shelf components for operational independence and designed to be repairable and recyclable.

1 investor

REMEC Broadband Wireless Networks designs and manufactures microwave and millimeter wave radios for wireless connectivity, serving mobile carriers, service providers, enterprise, and government customers. The company also provides block-up converters to the satellite communications market through its SAGE SatCom business arm.

1 investor

Renasens develops a CO₂-based, waterless recycling technology that separates blended textile waste such as polycotton into reusable high-quality fibers for the fashion and manufacturing supply chain. The deeptech company works with research institutes, spinners, manufacturers and brands, with a focus on Europe's circular manufacturing ecosystem.

1 investor

Rencom develops custom AI models trained on a company's proprietary data and deploys in-house AI agents for enterprise clients. It focuses on building tailored frontier models and autonomous agents for organizations.

1 investor

Renerva develops implantable medical devices to treat peripheral nerve injuries. The company was founded from academic research at the University of Pittsburgh and Cornell University.

1 investor

Renuvi develops a long duration energy storage system based on its proprietary Salt-Matrix sodium-based battery electrochemistry, aimed at providing reliable clean energy for the power grid. The company positions its technology as a manufacturable battery with higher energy density than other sodium-based designs.

1 investor

Reopia develops advanced optical solutions that prevent the onset and progression of myopia in children. The company addresses the growing global epidemic of nearsightedness through medical devices targeting pediatric eye health.

1 investor

RepAir develops electrochemical carbon capture technology for industrial emitters and direct air capture applications. The company serves industrial operators with diluted CO₂ streams (0-5%) as well as organizations seeking permanent carbon removal solutions through direct air capture and storage (DACS).

1 investor

RePG develops deep-tech energy and water systems that generate electricity, heating, cooling, and drinking water from air humidity and low-grade waste or geothermal heat (55-200°C). Its modular, off-grid, zero-emission devices serve industry, geothermal sites, homes, hotels, vehicles, data centers, and agriculture.

1 investor

Reprogram Biosciences develops an in vivo immunotherapy that uses a therapeutic gene cocktail delivered via lipid nanoparticles to reprogram solid-tumor cancer cells into immune-like cells. The company operates in the biotech and cancer therapeutics field, applying gene reprogramming and AI-driven bioinformatics to develop cell therapies for solid tumors.

1 investor

Interact is a 501(c)3 technology fellowship and research organization that runs a Technology Residency and Symposium, bringing together technologists to develop novel research, collaborations, and ideas across disciplines. Its residency pilots have been hosted in San Francisco and New York City.

1 investor

ResearchSat is a CRO/CDMO providing microgravity research services for biopharma and life-science teams, running staged studies from ground screening to orbital experiments to generate CMC-relevant data for biologics, formulations, and translational R&D. It designs experiments, builds payloads, manages missions, and delivers decision-grade datasets with regulatory-aware documentation for biotech companies, government agencies, and research institutions.

1 investor

ResFrac develops a fully coupled hydraulic fracturing and reservoir simulator, providing physics-based simulation software and consulting services for oil and gas operators to optimize well spacing, completion design, enhanced oil recovery, and geothermal systems. It serves the North American shale industry, from small independents to supermajors and national oil companies.

1 investor

ResilienX is a systems integrator for uncrewed aviation ecosystems, connecting multi-vendor technologies into a single coherent, safe, and scalable system for agencies and operators. It offers products including a vendor-neutral data exchange (AAM OptiX), model-based systems engineering, and an in-time aviation safety management system (FRAIHMWORK) supporting the low-altitude economy and advanced air mobility.

1 investor

ReSiTec develops process engineering solutions and produces metal and mineral powders for industrial applications. The company serves various industries requiring custom technology, products, and equipment, with particular expertise in powder and liquid solution handling.

1 investor

Resolian is a Contract Research Organization (CRO) that provides bioanalytical, biomarker, and analytical sciences services to support drug development for pharma and biotech companies. The company specializes in GxP and non-regulated bioanalysis, drug metabolism and pharmacokinetic services, and GMP CMC analytical and materials science across all therapeutic modalities.

1 investor

Resolve Nanotherapeutics is developing RNA drugs delivered via lipid nanoparticles that amplify the body's toxin-clearance pathway to treat severe acute bacterial infections and their chronic complications. Its host-focused therapy targets the immune system rather than the bacteria, aiming to work against antibiotic-resistant infections in critical care settings.

1 investor

ResoSight develops patent-protected technology that captures biometric data through everyday headphones and earbuds, without additional wearables or sensors. Its platform delivers health and wellness insights to consumers using devices they already own.

1 investor

Respiray manufactures a wearable personal air purifier that uses a HEPA filter to capture airborne allergens and protect individuals suffering from allergies and asthma. The device is designed as a portable, hands-free accessory that creates a protective shield of clean air around the wearer's face.

1 investor

ReSync Bio provided drug discovery teams with no-code access to AI tools for molecular design and analysis, removing the need to build their own infrastructure. The company has been acquired by Benchling and is sunsetting its platform.

1 investor