Deep Tech Startups

OSS manufactures testing technology for measuring contaminants in ammonia and related chemical products, including oil content, water content, and formaldehyde. The company provides extraction and analysis solutions for manufacturers of ammonia, DEF, urea, and related compounds.

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Otomagnetics develops a non-invasive magnetic injection system to deliver drugs and therapeutic payloads to the inner and middle ear, the eye, and the skin, aimed at treating conditions such as inner ear diseases. The technology has demonstrated drug delivery to the inner and middle ear in animal models without puncturing the eardrum.

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OyaGen is a preclinical drug discovery and development company that identifies and optimizes lead compounds as investigational new drugs for infectious diseases and cancer, then licenses or partners them with industry leaders for clinical development. It also offers fee-for-service assay development and high throughput screening to academic and industry partners.

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Pacific DT develops a patented prototype system emerging from university research with support from major health foundations and government agencies. The company is transitioning from research stage toward commercial clinical applications.

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Pandora Bio develops ML-based personalized diagnostics for mental health applications. The company works in the healthtech space, combining machine learning with clinical expertise to support diagnostic and therapeutic outcomes.

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ParcoData develops nuclear-powered, behind-the-meter data center campuses that generate their own clean electricity and use dry, sealed-loop cooling to serve hyperscaler and enterprise AI, inference, and HPC tenants. The campuses combine five revenue lines — powered shell leasing, on-site power contracts, immersion cooling technology, medical radioisotope production, and waste-heat carbon capture — anchored in Nevada with a planned six-metro U.S. footprint.</parameter> <parameter name="founders">[]

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ParkerVision develops radio-frequency and wireless communications technology used in mobile and consumer devices such as phones and earbuds, and is building technology aimed at reducing the cost of delivering 5G and 6G networks. The U.S.-based company focuses on semiconductor and RF innovation for next-generation wireless infrastructure.

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PDX Pharmaceuticals develops mesoporous silica nanoparticle platforms to co-deliver drugs, siRNA, and immunotherapy for treating multiple cancers and skin diseases. The company works in collaboration with OHSU on targeted and combination immunotherapeutics.

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Pebble Labs develops Directed Biotics technology, using microbes and RNA interference-based molecules to activate defense mechanisms in host crops. The company applies computational biology and bioinformatics to agricultural applications such as crop protection.

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Peloton Technology develops automated vehicle systems for the trucking industry, including collision mitigation radar, vehicle-to-vehicle communications, and a cloud-based Network Operations Cloud that enables trucks to platoon to reduce crashes and fuel use. Its technology serves commercial truck fleets and drivers.

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Penrove provides tools and frameworks designed to simplify essential, safety-critical tasks for organizations in complex, high-stakes environments. The company aims to help teams gain clarity and speed in their work to focus on innovation.

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PhenoVista provides contract research services focused on phenotypic and high-content imaging studies, using quantitative fluorescence microscopy and cell-based disease models to support R&D and drug discovery decisions. It serves life science and biotech researchers.

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Phio Pharmaceuticals is a clinical-stage biopharmaceutical company developing INTASYL, a proprietary self-delivering siRNA gene silencing technology that makes immune cells more effective at killing cancer cells. Its immuno-oncology pipeline targets cutaneous squamous cell carcinoma (cSCC) and melanoma.

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Plasmology4 develops Plaz4, a non-thermal (cold) plasma technology for medical applications, with its first product, the Plaz4 1000 system, aimed at treating antibiotic-resistant infections and chronic non-healing wounds. It is a pre-revenue medical device company in the emerging field of plasma medicine, and its lead product has received FDA Breakthrough Device designation but is not yet approved for sale.

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Pluristyx develops induced pluripotent stem cell (iPSC) technologies, including non-modified and genetically engineered cell lines, proprietary gene edits, and reprogramming platforms, along with related services. It provides these products and end-to-end development support to companies building cell and stem cell therapies.

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Polybiomics develops a live cell analysis platform that measures multiple phenotypes and functions of cells simultaneously and continuously without disrupting them or their 3D environments. The system combines a bioinstrument, consumable, and the PolyData analytics engine with AI to interpret multimodal datasets for research, pharmaceutical, biomanufacturing, and clinical workflows.

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Position Imaging develops high-precision asset localization and tracking systems that combine computer vision and radio frequency signals interpreted with AI and machine learning. Its purpose-built tracking solutions serve supply chain, retail, travel & leisure, and commercial & residential environments.

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Predictive Oncology develops drug discovery solutions for biopharma companies that combine artificial intelligence with a proprietary biobank of over 150,000 tumor samples to accelerate oncology drug development and improve therapeutic outcomes for cancer patients.

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Premier American Uranium (PUR) is a public uranium exploration and mining company with projects across Wyoming, New Mexico, Colorado, Utah, and Arizona.

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Primordial Labs is a defense technology company building combat capability for national security missions, founded by a team of engineers and former special operators. It focuses on understanding warfighter challenges across military domains.

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Product Creation Studio is a product design and development consultancy offering electrical, mechanical, and firmware engineering, industrial design, human factors, UX, quality engineering, and project management services. It serves R&D executives, corporate intrapreneurs, and startup CEOs as an extension of their teams, with expertise including regulated medical device development.

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Prolifagen develops microRNA (miR) technology to stimulate the regeneration of heart muscle damaged by myocardial infarction, aiming to prevent scar tissue formation and restore cardiac function. The company targets physicians and heart attack patients seeking solutions to prevent heart failure and recurrent cardiac events.

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Propria develops a patented system for producing and analyzing human engineered heart tissue (hEHT), generating detailed datasets on the contractile function of human cardiac tissue. It serves academic groups, pharmaceutical companies, and biotech and gene therapy firms.

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Protein Metrics develops vendor-neutral mass spectrometry data analysis software for protein and oligo characterization and quantification, used by laboratories and enterprises in biopharmaceutical development. Its products, including Byosphere, support protein characterization workflows across the drug development process.

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