Deep Tech Startups

Promethion Industries develops autonomous unmanned aircraft and naval systems along with AI combat pilots for defence applications, and generates high-fidelity synthetic training data in virtual environments to train defence AI. It focuses on counter-UAS capabilities and maritime/aerial ISR, working with NATO divisions to support European defence resilience.

1 investor

Promin Aerospace develops small orbital launch vehicles using proprietary gasification technology to eliminate space debris by consuming rocket engine tanks during flight. The company targets pico and nano satellite deployment with rapid launch timelines.

1 investor

Propel Space develops spacecraft mechanisms and provides engineering support services including mechanical and electrical design, systems and program management, and space environmental testing for spacecraft programs. It offers both in-depth and surge resource solutions for design, analysis, and testing.

1 investor

Prophecy Sciences builds a suite of cognitive tests that combine behavioral measures with biosignal sensors to quantify factors such as mental aptitude, personality, and decision-making styles. It uses this neuroscience-based data to help employers hire the right candidates and help managers optimize and motivate their teams.

1 investor

ProSeed designs and manufactures microwave-based drying and separation systems that apply electromagnetic energy directly to moisture or solvents within products at industrial scale. The company serves pharmaceutical, minerals, and food processing industries with fully electric, material-specific processes.

1 investor

PROSION Therapeutics develops platform technology for oncology and other diseases based on research into protein targets like Ena/VASP; the company translates academic research into clinical treatments for conditions with significant patient impact.

1 investor

ProteoFormiX applies top-down proteomics to biobanked clinical tissue and liquid biopsy samples to identify human proteoforms and discover biomarkers for drug development and diagnostics. It focuses on neurodegenerative disorders, hard-to-diagnose diseases such as cancer, and biofluid-based proteomics (e.g. tears in ophthalmology), working with hospital pathology departments and pharmaceutical research groups.

1 investor

ProteomEdge develops mass spectrometry-based analytical platforms and proprietary heavy-labelled protein standard panels for absolute protein quantification in blood plasma, targeting clinically relevant biomarkers such as apolipoproteins, complement factors, and liver disease markers. Its products serve research and translational proteomics customers, including academic core facilities and precision medicine researchers. Based in Stockholm, Sweden.

1 investor

Proteros provides structural biology, cryo-EM, protein sciences, and biophysics research services for drug discovery and development. The company operates cutting-edge laboratory facilities in the Munich biotech cluster in Germany.

1 investor

Proto-Town describes an initiative to create a new place with frontier-oriented infrastructure intended to support fast building, experimentation, and reindustrialization. The page is a manifesto-style statement about restoring a culture of invention rather than a concrete product description.

1 investor

Protochips develops in situ sample holders and data management software for transmission electron microscopy (TEM), enabling researchers to observe materials under conditions like heating, cooling, and liquid electrochemistry. Its tools serve materials science research across areas such as battery, electrocatalyst, corrosion, and synthesis studies.

1 investor

ProTransit is developing Pro-MP, a patented sustained-release microparticle drug delivery platform that penetrates skin, scalp, eye, and mucosal tissues (and can be IV-administered) to deliver pharmaceutical active ingredients locally with minimal systemic uptake. Based on research from the University of Nebraska Medical Center, Creighton University, and USC Keck School of Medicine, the technology targets applications such as skin health and hair regrowth.

1 investor

Provenant builds open infrastructure for verifiable digital communications and branded calling, using cryptographic proof (vLEI, KERI, ACDC) to authenticate calls and messages and support fraud detection and regulatory compliance. Its Origin API platform serves telecommunications operators, enterprises, and sectors such as healthcare, financial services, government, and supply chain.

1 investor

Proxisense develops high-performance sensors for monitoring manufacturing processes and diagnostics, with origins in aerospace and defence applications. The company commercializes sensor technologies initially developed for jet engines and oil monitoring.

1 investor

PR Photonics develops silicon photonic integrated circuits for optical interconnect and computing, aiming to address challenges in silicon photonic devices. Its technology targets AI chip connectivity and scalable photonic AI computing.

1 investor

PS Audio Design develops audio and haptic surface technology that enables devices to produce sound and tactile feedback directly from their surfaces. The company serves device manufacturers seeking to enhance user experience through improved audio and haptic capabilities.

1 investor

PSI (Physical Superintelligence) is building a physics research lab that uses AI-driven "Autonomous Campaigns" — directed research efforts run by virtual physicists under human direction — to create world models, engineer physical systems, and discover new physical laws. Its initial focus is the physical infrastructure of AI, and it operates as a public benefit corporation.

1 investor

The Physical Superintelligence (PSI) Lab at USC is a research group developing robotic systems, including multimodal data engines, learning pipelines, and deployment software that let humanoids and mobile platforms perform dexterous, contact-rich tasks. Its research covers 3D scene understanding, whole-body humanoid control, and dexterous manipulation to build physical AI agents that operate autonomously in human environments.

1 investor

Psigryph develops nanoparticle and nanofibre platform technologies to deliver nutrients and insoluble drug molecules into cells, with applications ranging from cancer therapeutics to consumer dietary supplements. It also offers biofertilizers, biopesticides, and phytonutrient-based health products.

1 investor

Psylotech designs and builds miniature mechanical load frames that integrate with imaging systems such as beamlines, microCT, nanoCT, XRD, and optical and electron microscopes, using DIC and DVC to characterize materials across length scales. It serves materials researchers and experimentalists in academic, synchrotron, and lab testing settings.

1 investor

PsyMed Ventures is a venture capital firm that invests in startups advancing brain and mental health through neuroscience and frontier technologies, including neurotech, brain-computer interfaces, digital health, precision neuroscience, and novel therapeutics. It backs founders working on neurotech, biotech, and digital health companies.

1 investor

PTX provides engineering services and strategic materials technology to U.S. Federal customers in the aerospace and energy sectors, drawing on experience across commercial and Federal projects. It offers technical and project management capabilities for critical missions and national assets.

1 investor

Pulsar Photonics develops, manufactures, and sells laser machines for micromachining with short-pulse and ultrashort-pulse lasers, and also offers contract manufacturing services such as laser drilling, structuring, fine cutting, and surface functionalization. It serves industrial sectors including medical and pharmaceutical technology, semiconductors, electronics, tooling, recycling, and ceramics, and is based in the Aachen region of Germany.

1 investor

Pumpkin VR develops AI-driven guide systems and extended reality simulation training solutions for museums, defense operations, medical education, and industrial safety across government facilities, hospitals, and enterprises. The company offers six solution categories including AI tour narration, XR/VR/MR immersive training, and AI eldercare interaction systems, deployable on cloud, private cloud, on-premise, or fully offline infrastructure.

1 investor