Deep Tech Startups

PoWx is a non-profit organization that develops proof-of-work cryptography designed to be compatible with energy-efficient optical computing. Its optical proof-of-work (oPoW) is used by cryptocurrencies such as Kaspa.

1 investor

Perfect Point EDM manufactures electrical discharge machining (EDM) tools and equipment for aerospace applications, serving defense contractors and aircraft manufacturers. The company specializes in precision machining solutions for the aerospace and defense industries.

1 investor

Pravah builds asset discovery and network mapping for utilities, reconstructing grid topology, asset condition, vegetation risk, and source-to-endpoint connectivity from satellite, drone, street view, and field imagery combined with existing records.

1 investor

Precise Bio is a regenerative medicine company that develops bio-printed tissues and organs using a 4D bio-fabrication platform, initially focused on ophthalmology including a fabricated human cornea program. It serves patients with unmet medical needs that cannot be met with donor tissue, with facilities in North Carolina, USA and Shoham, Israel.

1 investor

Precision Chroma develops 3D-printed chromatography columns using patented technology for laboratory and analytical applications. The company is a spinoff from the University of Canterbury focused on next-generation separation and analysis equipment for the chemical and life sciences industries.

1 investor

PrecisionPhage develops computational and laboratory solutions for bacteriophage research to address antimicrobial resistance. The company creates bioinformatics tools and phage-based technologies intended for healthcare and biotech applications globally.

1 investor

Predictive Oncology develops drug discovery solutions for biopharma companies that combine artificial intelligence with a proprietary biobank of over 150,000 tumor samples to accelerate oncology drug development and improve therapeutic outcomes for cancer patients.

1 investor

PredictXBio uses AI, machine learning, and bioinformatics pipelines to predict how pathogens respond to drugs and to model antimicrobial potency in silico, aiming to accelerate discovery of antimicrobials against antimicrobial resistance. Its tools serve drug developers by predicting future resistance mutations and testing therapeutic compounds computationally.

1 investor

RTX designs, builds and supports aerospace systems and defense technologies, serving commercial aviation and national defense customers. It combines advanced digital tools and scalable design and manufacturing approaches across three aerospace and defense businesses.

1 investor

PreDxion Bio develops a rapid saliva-based antigen test for detecting SARS-CoV-2 S-protein in asymptomatic and presymptomatic patients, scalable using semiconductor fabrication processes. Its original technology, spun out of the University of Michigan, is a near real-time cytokine and biomarker detection platform for monitoring immune response in critically ill patients, including those undergoing CAR-T therapy.

1 investor

Framto develops battery materials, with a focus on next-generation battery technology.

1 investor

A healthcare-focused company spun out from Hamamatsu University School of Medicine that aims to develop disease treatments and save patients' lives through scientific innovation. The company also contributes to disaster preparedness and emergency medical response in the Hamamatsu region.

1 investor

Presage is an AI research lab that builds "world models" for cloud infrastructure, trained on production data to learn how services, workloads, and resource consumption interact and evolve over time. Its first model, Cloud-1, deploys inside AWS environments to predict cost trajectories, simulate infrastructure changes, trace incident root causes, and support autonomous infrastructure management.

1 investor

Present Future is an award-winning nonfiction book examining how technology has shaped society, the economy, and the environment over history and the origins of key technologies driving the current "Deep Tech Revolution." It covers fields ranging from biotechnology and cybersecurity to robotics, energy, aerospace, and artificial intelligence.

1 investor

Presto Engineering provides semiconductor design and manufacturing services, serving industrial, medical, automotive, and IoT sectors. The company specializes in custom silicon solutions and high-speed optical communication ASICs.

1 investor

Pretia develops augmented reality technology and products for real-world shared experiences, including app-free AR for events, remote support tools, and factory work-process analysis. Its offerings serve major companies for customer engagement, onsite technical support, and manufacturing analysis.

1 investor

PRIMACYT develops isolated liver cell models and toxicity testing services for medical device and pharmaceutical research. The company serves research institutions, universities, and industrial clients requiring preclinical safety assessment capabilities.

1 investor

Primal Therapies develops microbial biotechnology, including patented small molecule drugs and functional ingredients for biofilm management, infection control, and microbiome modulation. Its SMMRT platform targets metabolic receptors and enzymes in bacteria, viruses, and fungi to address antimicrobial resistance, disinfection, and chronic disease across healthcare and other industries.

1 investor

Primary Bioscience is developing a single-molecule protein sequencing device for comprehensive, multi-biomarker screening. The technology aims to sequence every protein in a sample, including hard-to-detect variations such as single residue substitutions, splice variants, and post-translational truncations.

1 investor

Primate AI builds Darwin, a JEPA-based video model that analyzes camera or uploaded video in real time and answers prompts about what is happening, without relying on text-label token prediction. It targets developers and offers an API that runs with cloud-level accuracy on edge hardware such as Jetson, MacOS, iOS, and Snapdragon.

1 investor

Primate Intelligence builds Darwin, a JEPA-based video perception model that produces deterministic, timestamped, confidence-scored outputs queryable in plain English, delivered as an API. It targets engineers and AI agents needing to extract structured data from video.

1 investor

Prime Lightworks Inc. builds electric propulsion systems for space satellites, aiming to lower cost and waste in space operations.

1 investor

Primemas develops chiplet-based platform SoCs and hardware architectures for AI data infrastructure, custom AI chip acceleration, and reconfigurable FPGA solutions. Its Hublet architecture targets datacenter operators, chip designers, and developers building large-scale AI, database, and physical AI systems.

1 investor

Primitive builds an Immersive Development Environment that analyzes source code and displays it as interactive 3D structures for collaborative work in virtual reality. It offers plugins for popular IDEs, aimed at software development teams working to comprehend and integrate code from multiple authors.

1 investor