Deep Tech Startups

PowerLight Technologies (a dba of LaserMotive, Inc.) develops optical power beaming systems that convert electricity into high-intensity light, transmit it over long distances, and reconvert it to usable power at a specialized receiver. The company is developing transmitter and receiver systems to wirelessly charge aerial drones, targeting defense, telecom, and digital infrastructure applications.

1 investor

PowerSpin develops spintronics-based power semiconductors and high-efficiency power electronics technology, offering intellectual property licensing, circuit designs, and consulting services.

1 investor

PoWx is a non-profit organization that develops proof-of-work cryptography designed to be compatible with energy-efficient optical computing. Its optical proof-of-work (oPoW) is used by cryptocurrencies such as Kaspa.

1 investor

Perfect Point EDM manufactures electrical discharge machining (EDM) tools and equipment for aerospace applications, serving defense contractors and aircraft manufacturers. The company specializes in precision machining solutions for the aerospace and defense industries.

1 investor

Alluris manufactures force and torque testing and measurement devices for industrial applications. The company serves diverse industrial sectors with precision testing instruments and offers calibration and maintenance services.

1 investor

Pramatra Space develops satellite-based quantum key distribution (QKD) systems using integrated photonics chips to deliver encryption keys to enterprises. The company provides quantum cryptography solutions designed to protect digital assets against ransomware and future quantum computing attacks.

1 investor

Prazer Therapeutics develops therapeutics using Targeted Protein Degradation (TPD) technology, including its SPiDEM platform, in which small molecules selectively bind pathological proteins and activate the ubiquitin-proteasome system for their elimination. The company's pipeline focuses on treatments for viral infections and associated diseases as well as other refractory conditions.

1 investor

Precise Bio is a regenerative medicine company that develops bio-printed tissues and organs using a 4D bio-fabrication platform, initially focused on ophthalmology including a fabricated human cornea program. It serves patients with unmet medical needs that cannot be met with donor tissue, with facilities in North Carolina, USA and Shoham, Israel.

1 investor

Precision Chroma develops 3D-printed chromatography columns using patented technology for laboratory and analytical applications. The company is a spinoff from the University of Canterbury focused on next-generation separation and analysis equipment for the chemical and life sciences industries.

1 investor

Precision Microbubbles develops the M Sorter, a benchtop device that purifies commercially available microbubble suspensions into uniform-sized populations for scientific and medical applications. The device is designed for researchers and clinicians who require consistent, monodisperse microbubbles without complex synthesis processes.

1 investor

PrecisionPhage develops computational and laboratory solutions for bacteriophage research to address antimicrobial resistance. The company creates bioinformatics tools and phage-based technologies intended for healthcare and biotech applications globally.

1 investor

PredictXBio uses AI, machine learning, and bioinformatics pipelines to predict how pathogens respond to drugs and to model antimicrobial potency in silico, aiming to accelerate discovery of antimicrobials against antimicrobial resistance. Its tools serve drug developers by predicting future resistance mutations and testing therapeutic compounds computationally.

1 investor

RTX designs, builds and supports aerospace systems and defense technologies, serving commercial aviation and national defense customers. It combines advanced digital tools and scalable design and manufacturing approaches across three aerospace and defense businesses.

1 investor

A healthcare-focused company spun out from Hamamatsu University School of Medicine that aims to develop disease treatments and save patients' lives through scientific innovation. The company also contributes to disaster preparedness and emergency medical response in the Hamamatsu region.

1 investor

Presage is an AI research lab that builds "world models" for cloud infrastructure, trained on production data to learn how services, workloads, and resource consumption interact and evolve over time. Its first model, Cloud-1, deploys inside AWS environments to predict cost trajectories, simulate infrastructure changes, trace incident root causes, and support autonomous infrastructure management.

1 investor

Present Future is an award-winning nonfiction book examining how technology has shaped society, the economy, and the environment over history and the origins of key technologies driving the current "Deep Tech Revolution." It covers fields ranging from biotechnology and cybersecurity to robotics, energy, aerospace, and artificial intelligence.

1 investor

Presto Engineering provides semiconductor design and manufacturing services, serving industrial, medical, automotive, and IoT sectors. The company specializes in custom silicon solutions and high-speed optical communication ASICs.

1 investor

PRIMACYT develops isolated liver cell models and toxicity testing services for medical device and pharmaceutical research. The company serves research institutions, universities, and industrial clients requiring preclinical safety assessment capabilities.

1 investor

Primal Therapies develops microbial biotechnology, including patented small molecule drugs and functional ingredients for biofilm management, infection control, and microbiome modulation. Its SMMRT platform targets metabolic receptors and enzymes in bacteria, viruses, and fungi to address antimicrobial resistance, disinfection, and chronic disease across healthcare and other industries.

1 investor

Primate Intelligence builds Darwin, a JEPA-based video perception model that produces deterministic, timestamped, confidence-scored outputs queryable in plain English, delivered as an API. It targets engineers and AI agents needing to extract structured data from video.

1 investor

A precision-medicine company that uses radiochemistry and molecular imaging to develop and manufacture radioisotope-based diagnostic and therapeutic drugs, focused on hard-to-treat cancers. It also pursues drug-development partnerships built on its radioisotope platform technology.

1 investor

Primrose Bio develops high-efficiency production systems for innovative and complex biologics, using advanced protein expression and enzyme engineering technologies deployed across commercially proven platforms. The company serves pharmaceutical developers and contract manufacturers in the biopharmaceutical industry.

1 investor

Principal Mineral develops and commercializes critical materials for AI infrastructure, energy security, and advanced manufacturing through a portfolio of operating companies and process technologies. The company provides scaled production of mineral and material inputs for electronics, defense, and energy industries with supply chain visibility and intelligence tools.

1 investor

Principia Labs is a research lab that trains its own models from scratch to perform original mathematical and scientific reasoning. Based in San Francisco, it focuses on advancing AI for mathematics that underpins scientific breakthroughs.

1 investor