Deep Tech Startups

Delft Circuits builds Cri/oFlex superconducting cabling that replaces conventional wiring inside cryostats, offering higher channel density and lower thermal load as quantum I/O infrastructure. It designs, manufactures, and validates these systems in-house for the quantum computing industry.

1 investor

Deliver Biosciences develops a nanoparticle-based delivery platform to genetically engineer cells in patients for cell and gene therapies, targeting cancer immunotherapies as the first indication with applications in autoimmune, neurodegenerative, and cardiovascular diseases.

1 investor

DELiver Therapeutics develops small molecule and peptide therapeutics using high-throughput DNA encoded library (DEL) drug screening to address challenging and previously "undruggable" targets in clinical medicine, with a focus on tyrosine kinase targets. Its R&D facilities are located at K2Bio in Houston.

1 investor

Deliver Biosciences develops a nanoparticle-based delivery platform to genetically engineer cells inside patients (in vivo) for cell and gene therapies, using programmable targeting to transport payloads such as DNA and mRNA to specific cell types. Its first product targets T-cells to deliver a CAR gene for cancer immunotherapy, with longer-term applications in autoimmune, neurodegenerative, and cardiovascular diseases.

1 investor

Ponce Aurora (deliverthera.com) develops small molecule kinase inhibitors discovered through DNA-encoded library (DEL) screening, including a multi-kinase inhibitor targeting ABL1-T315I and other tyrosine kinases for patients with Ph+ acute lymphocytic leukemia. The company also develops selective JAK/TYK2 inhibitors as senomorphic therapies to regulate the senescence-associated secretory phenotype (SASP) in aging and age-related diseases.

1 investor

Delox develops proprietary bio-decontamination solutions using solid-formulated hydrogen peroxide technology for healthcare, pharmaceutical, laboratory, and industrial environments where contamination control is critical. The company operates across Europe and North America, serving organizations in highly controlled settings that require precision decontamination with zero tolerance for failure.

1 investor

Delta Black Aerospace designs and manufactures the RAIDER 330, a hybrid-electric unmanned aerial system for military and defense applications. The system combines vertical takeoff and landing capabilities with extended endurance and modular payload capacity for intelligence, surveillance, and reconnaissance missions.

1 investor

Delta Diagnostics (Delta Life Science) develops label-free, multiplexed biosensing instruments based on photonic integrated circuits, aimed at faster research and lower cost of ownership than existing methods like ELISA. It serves life sciences researchers, assay developers, academic researchers, and pharma scientists working on diagnostics, drug development, biomarker assays, and biomolecular interaction studies.

1 investor

Demeetra is a genome engineering company that develops precision gene-editing platforms — including Cas-CLOVER, Harbor-IN and Super piggyBac transposases and CleanCut CHO host cell lines — along with integrated cell line development and GMP manufacturing services. It serves biopharmaceutical developers through flexible licensing and service models for cell line development, biomanufacturing, and discovery programs.

1 investor

DENKweit develops vision AI technology for industrial quality and data management applications. The company, a Fraunhofer spin-off based in Germany, builds image analysis systems designed to be accessible and deliver practical value across industries.

1 investor

DeNoize develops active noise-cancellation window technology that uses adaptive sound monitoring to reduce urban noise in residential spaces. The company serves homeowners and properties affected by environmental noise, operating in the acoustic comfort and sustainable building technology sector.

1 investor

DenovAI Biotech uses artificial intelligence and computational molecular biophysics to design proteins de novo, building platforms for rapid antibody discovery and bespoke high-affinity binders. The company targets therapeutic and diagnostic applications, including antibodies, peptide biologics, and diagnostic reporters for drug discovery.

1 investor

Denovo Sciences develops an AI platform for structure-based small-molecule drug discovery, using generative algorithms to design candidate molecules de novo within a target's binding pocket and predict their synthesizability and drug-likeness. It runs its own drug discovery programs and partners with others to identify small-molecule drug candidates, including work on broad-spectrum influenza inhibitors.

1 investor

Deorbital Devices provides space logistics services including satellite last-mile delivery, orbital transportation, hosted payload operations, mission control, and space waste management, using a proprietary orbital transfer vehicle. It targets satellite operators and the broader space economy with in-orbit transportation and infrastructure.

1 investor

Deployable Energy builds the Unity Nuclear Battery, a compact, modular, transportable 1 MW microreactor system that provides continuous clean power. It targets industrial, defense, humanitarian, and remote applications, and is preparing an initial reactor demonstration at Idaho National Laboratory.

1 investor

Desentum is a clinical-stage biopharmaceutical company developing allergen immunotherapy products that reprogram immune responses to allergens toward tolerance. The company targets both respiratory and food allergies, with its lead asset currently in phase II clinical trials.

1 investor

D2S develops GPU-accelerated computing and deep learning technologies for semiconductor manufacturing, focusing on curvilinear mask data preparation and inverse lithography. Its products support photomask production and lithography workflows in the semiconductor industry.

1 investor

Detail Earth provides high-resolution aerial imagery, down to 5 cm resolution with vertical and oblique views updated three times a year, accessible on any device. It includes AI-based measurement tools, 3D visualization, map editing, and an AI copilot for turning imagery into insights.

1 investor

D&I Solutions develops technology to detect and interdict unauthorized wireless communications, targeting contraband cell phone use by inmates in correctional facilities. The system focuses on identifying and blocking unauthorized cellular calls made from within prisons.

1 investor

Detraxi is a privately held company developing emerging technology, seeking development funding and licensing partnerships. The page provides limited detail about the specific product or industry.

1 investor

DEVAR develops AI-powered augmented reality technology, including a platform that generates AR experiences, 3D models, and interactive content from text descriptions, and a Large Geospatial Model for spatial mapping and persistent AR content placement. It serves creators, brands, and enterprises across sectors such as retail, education, manufacturing, marketing, arts, and architecture.

1 investor

Dewpoint Innovations develops functional nanostructured polymeric surfaces for atmospheric water capture, technology originating from PhD research at the University of Sydney. The company applies surface coating and materials science to sustainable water-generation and climate technologies.

1 investor

Dexlabs is an engineering design and manufacturing services firm offering product design, 3D modeling, rapid prototyping via 3D printing, additive manufacturing, and injection molding design. It works with startups and large enterprises across industries such as consumer electronics to take ideas from concept to full-scale production.

1 investor

DGG builds RapidPipeline, software for automating 3D content pipelines that lets companies process and optimize 3D models as easily as 2D images. It serves studios, brands, retailers, and platform companies for digital production and marketing workflows.

1 investor