Deep Tech Startups

Delphos Labs uses AI-powered reverse engineering to detect malware and hidden risk in compiled code without requiring source code. It serves enterprise and security-focused customers in the cybersecurity industry.

2 investors

Delta Life Science develops the inQuiQ, a label-free biosensing instrument that uses integrated photonics to measure biomolecular binding affinity and kinetics (KD, ka, kd) in real time from small sample volumes. It serves academic research institutes, biotech R&D, and CROs/CDMOs as an alternative to surface plasmon resonance and bio-layer interferometry for applications such as antibody characterization, small molecule and fragment screening, and PROTAC/molecular glue analysis.

2 investors

Denovo Sciences develops an AI platform for structure-based small-molecule drug discovery, using generative algorithms to design candidate molecules de novo within a target's binding pocket and predict their synthesizability and drug-likeness. It runs its own drug discovery programs and partners with others to identify small-molecule drug candidates, including work on broad-spectrum influenza inhibitors.

2 investors

D2S develops GPU-accelerated computing and deep learning technologies for semiconductor manufacturing, focusing on curvilinear mask data preparation and inverse lithography. Its products support photomask production and lithography workflows in the semiconductor industry.

2 investors

Dewpoint Innovations develops functional nanostructured polymeric surfaces for atmospheric water capture, technology originating from PhD research at the University of Sydney. The company applies surface coating and materials science to sustainable water-generation and climate technologies.

2 investors

Hologic Diagenode provides epigenomics profiling services and sample preparation products for next-generation sequencing, proteomics, and epigenetics research. It serves biomarker discovery and validation through epigenomics and bioinformatics for research applications.

2 investors

Dialybrid develops vascular grafts for hemodialysis using Silkothane®, a hybrid material combining silk fibroin and polyurethane, targeting nephrologists and dialysis centers. The company focuses on advanced biomedical devices in the tissue engineering and regenerative medicine sector.

2 investors

Diamond Quanta develops the Adamantine Platform, an engineered-diamond interface technology for optical, thermal, semiconductor, photonic, and quantum systems. The company serves semiconductor, aerospace/defense, and consumer electronics industries with diamond-based solutions for power electronics and quantum devices.

2 investors

digiLab provides an AI platform called the Uncertainty Engine that helps organizations and governments tackle complex, high-stakes challenges by combining machine learning with uncertainty quantification for safer, more explainable decision-making. The platform is purpose-built for safety-critical domains including advanced energy, critical infrastructure, cybersecurity, and environmental conservation.

2 investors

Dimenco develops a platform combining spatial AI software and switchable-display hardware that enables immersive content experiences on standard consumer devices without requiring new hardware. The platform allows users to view movies, images, and social media with lifelike holographic depth effects on phones, tablets, monitors, and laptops.

2 investors

DINYA DNA builds an enzymatic "Exponential Synthesis" platform that directly synthesizes long, complex double-stranded DNA up to 5kb from a pre-built material library without oligo assembly, delivering custom sequences in 3-10 days. It serves scientists through an Early Access synthesis service, planned to launch in 2026, in the synthetic biology and gene synthesis space.

2 investors

Discovery Loop builds AI systems that automate the experimental loops of scientific and engineering research, using frontier AI models and large-scale computing to propose, run, and learn from thousands of experiments in parallel. The company is initially focused on automating machine learning research and engineering before expanding to other science and engineering domains.

2 investors

DISC Alloys develops metal manufacturing and materials technology aimed at aerospace, defense, and high-performance industrial applications. The company applies materials science and advanced manufacturing methods to produce components for these sectors.

2 investors

Dispelix develops and supplies transparent waveguides that function as see-through displays for consumer and enterprise augmented reality devices. The company manufactures custom waveguide display components for high-volume and high-value AR markets through carefully vetted production partners.

2 investors

Distributed Spectrum builds software for radio spectrum management that combines machine learning, signal processing, and embedded systems. The company serves stakeholders in the radio domain with modular, flexible solutions positioned between low-cost hardware and expensive legacy systems.

2 investors

Divitel provides AI-driven operational intelligence and autonomous operations management for telecom operators and media companies managing video and broadband networks. The company leverages proprietary platforms, real-time data pipelines, and domain-trained AI models built on 25+ years of operational expertise.

2 investors

Particella, Inc. (formerly DNAlite Therapeutics) is a preclinical biotechnology company developing an oral lipid nanoparticle platform to deliver nucleic acids, such as mRNA, to the intestinal epithelium. It focuses on oral mRNA medicines.

2 investors

Dognosis builds "olfaction AI" that pairs trained biomedical detection dogs with a non-invasive canine brain-computer interface and machine learning to identify disease-associated volatile organic compounds in breath samples. Its breath-based screening is aimed at early, multi-cancer detection and produces a VOC risk score for clinicians.

2 investors

Domaille Engineering manufactures ultra-precision fiber optic polishing equipment and fixtures for telecommunications manufacturers, featuring proprietary technology that reduces polishing time and extends tool life.

2 investors

Dorm Room Fund is an investment fund that provides capital, mentorship, and investor network access to student-led startups. The fund identifies and backs early-stage companies founded by currently enrolled or recently graduated students.

2 investors

DotBlocks develops a cloud-based numerical simulation platform for solving fluid dynamics and thermal problems using advanced methods like lattice Boltzmann modeling. The platform serves industrial R&D teams and researchers who need to run complex transient simulations and parametric studies.

2 investors

Dottir Labs is an MIT spinout developing reagent-free optical sensor systems for real-time, detailed chemical analysis of water, detecting nutrients, metabolic markers, and organic and non-organic waste products. Its sensors serve aquaculture production, environmental sensing, and manufacturing processes.

2 investors

Draupnir Bio develops targeted protein degradation therapies using sortilin-based lysosome targeting chimeras to clear extracellular and membrane-bound protein aggregates in proteinopathies. The company, a spin-out from Aarhus University and Max-Planck Society, builds proprietary platform technology to treat diseases with significant unmet medical need.

2 investors

Dream Photonics works on integrated photonics for use across a large number of devices. The company operates from Vancouver, Canada and Woodinville, Washington, USA.

2 investors