Fundraising Fox

Ophelia

YC W20

New York City, US · Founded 2019 · Delaware corporation · 250 employees · Hiring · 10 known investors

Ophelia provides medication-assisted treatment for opioid addiction through a telemedicine platform, allowing patients to receive care without attending residential rehab. The service is designed for individuals struggling with opioid addiction who prefer privacy-respecting, home-based treatment options.

Also known as Ophelia Health · Ophelia Health Inc.

Founders & leadership· Y Combinator alumni (W20)

Ophelia was founded in 2019 by Mattan Griffel and Zack Gray.

MGMattan Griffel
Mattan Griffelin𝕏Co-founder · Board ObserverMattan Griffel studied philosophy and finance at New York University and holds a position as faculty at Columbia Business School. He co-founded Ophelia, a Y Combinator-backed company developing opioid cessation treatment, and is an Innovation Fellow at Columbia's Lang Center for Entrepreneurship.
ZGZack Gray
Zack Grayin𝕏Founder & CEO
DADr. Arthur Robin Williams
Dr. Arthur Robin WilliamsCodesigner

Board

GYGreg Yap
Greg Yapin𝕏Board Member & InvestorPartner at Menlo Ventures
DADr. Adam Bisaga
Dr. Adam BisagaCodesigner

Investors · 10

Also in the syndicate · 2

Elliot CohenTrucks Venture Capital

Reported raises · per SEC filings

Form D private placements

$68.4M disclosed across 3 of 4 rounds · 2020–2021

$50MraisedDec 2021 · 21 investors · Other
Rule 506(b)
Officers, directors & promoters on the filing
  • Greg YapDirector
  • Zack GrayExecutive Officer, Director, Promoter
  • Mattan GriffelExecutive Officer, Director, Promoter
Offering amount
$50M
Amount sold
$50M
First sale
Dec 2021
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$15MraisedApr 2021 · 19 investors · Other
Rule 506(b)
Officers, directors & promoters on the filing
  • Zack GrayExecutive Officer, Director, Promoter
  • Greg YapDirector
  • Mattan GriffelExecutive Officer, Director, Promoter
Offering amount
$15M
Amount sold
$15M
First sale
Apr 2021
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
$3.4MraisedMay 2020 · 27 investors · Other
Rule 506(b)
Officers, directors & promoters on the filing
  • Mattan GriffelExecutive Officer, Director
  • Zack GrayExecutive Officer, Director, Promoter
Offering amount
$3.4M
Amount sold
$3.4M
First sale
Apr 2020
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

The YC application· Winter 2020 batch

Company profile

researched Aug 2026

Ophelia (legal name Ophelia Health Inc.) is a New York City-based digital health provider that delivers medication-assisted treatment (MAT) for opioid use disorder through telemedicine. Patients enroll online, meet a dedicated clinical care team over Zoom video visits, and, if eligible, receive a prescription for Suboxone (buprenorphine plus naloxone) or its generic equivalent sent to a local pharmacy. Beyond the core medication, clinicians can prescribe comfort medications for withdrawal symptoms such as nausea and insomnia and treat commonly co-occurring conditions including depression and anxiety [0][2][3].

The care model is built around removing the barriers associated with residential rehab: no travel, no mandatory groups or 12-step attendance, appointments available seven days a week, and an intake process the company says results in being seen within one to three days. Care teams combine clinicians, nurses, care coordinators, enrollment coordinators and peers; triage nurses provide round-the-clock clinical support. Visit cadence is weekly during the first month of stabilization, biweekly thereafter, and monthly after roughly three months [0][2][3].

Clinically, the company describes a digitally native model adapting the Massachusetts Collaborative Care Model to telemedicine, with synchronous video visits, FDA-approved medications, urine drug screens, on-demand messaging, optional groups, and care coordination. Ophelia was co-designed by addiction psychiatrists Dr. Arthur Robin Williams (Chief Medical Officer) and Dr. Adam Bisaga (Senior Medical Director), both academic researchers at Columbia University / New York State Psychiatric Institute [4][5].

Compiled by commissioned research from 8 cited public sources — announcements, filings, and press listed under research sources below.

Key figures

latest reported
Cash-pay subscription priceJan 2026$245
HeadcountAug 2026383
Lives covered by payer contractsDec 202175,000,000 covered lives
Patients in treatmentJan 2020400 patients
Six-month patient retentionDec 202170%
States of operation (listed on website)Jan 202615 states
States servedDec 202127 states
Team sizeJan 2026250 employees
Total funding raisedDec 2021$68M
Twelve-month patient retentionDec 202160%
Typical insured patient costJan 2026Most patients pay less than $10 per month

Company-reported or press-reported figures, each dated to when it was claimed — not independently audited.

Founder mafia

4 people who came through Ophelia went on to found or lead other companies.

Competitors · 2

by search overlap

Companies competing with Ophelia for the same Google search keywords, organic and paid, via search-intersection analysis.

Timeline · 6

launches, deals, and filings
Dec 2021
Operations expanded to 27 states

By the time of the Series B, Ophelia reported expansion to 27 states and payer contracts covering 75 million lives across Medicare, Medicaid and commercial plans.

source ↗

Dec 2021
Ophelia raises $50M Series B led by Tiger Global

Ophelia Health Inc. announced a $50 million Series B led by Tiger Global Management, with participation from Good Friends, Menlo Ventures, General Catalyst, Refactor Capital, 640 Oxford Ventures, Interplay Ventures and PillPack co-founder Elliot Cohen. Proceeds were earmarked for U.S. expansion, payer and partner integrations, and a clinician recruitment and retention platform.

$50M source ↗

Apr 2021
Series A of $15 million

$15M source ↗

Jan 2020
Seed round of $2.7 million

Press coverage referenced on Ophelia's site describes the YC-backed company raising $2.7 million to help people quit opioids without rehab.

$2.7M source ↗

Jan 2020
Participated in Y Combinator Winter 2020 batch

Ophelia is listed as a Y Combinator Winter 2020 company in the Mental Health Tech, Healthcare and Telemedicine categories.

source ↗

Jan 2020
First patient treated

The company treated its first patient in 2020.

source ↗

Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.

Legal entities · 1

corporate structure
OpheliaDelaware

In the news

Research sources · 8

primary sources listed

8 public sources were cited for this profile; the first-party ones are listed here.

Frequently asked questions

What does Ophelia do?
Telemedicine provider of medication-assisted treatment (Suboxone) for opioid use disorder, delivered to patients at home.
Who founded Ophelia?
Ophelia was founded by Mattan Griffel, Zack Gray in 2019.
Who are Ophelia's investors?
Ophelia's investors include Menlo Ventures, Y Combinator, Four Acres Capital, Good Friends, General Catalyst, Interplay Ventures Early Stage Management Llc, Refactor Capital, Tiger Global Management.
How much funding has Ophelia raised?
Ophelia has disclosed $68.4M raised across 3 of its 4 known rounds.
Where is Ophelia headquartered?
Ophelia is headquartered in New York City, US.