Ophelia
YC W20New York City, US · Founded 2019 · Delaware corporation · 250 employees · Hiring · 10 known investors
Ophelia provides medication-assisted treatment for opioid addiction through a telemedicine platform, allowing patients to receive care without attending residential rehab. The service is designed for individuals struggling with opioid addiction who prefer privacy-respecting, home-based treatment options.
Also known as Ophelia Health · Ophelia Health Inc.
Founders & leadership· Y Combinator alumni (W20)
Ophelia was founded in 2019 by Mattan Griffel and Zack Gray.

Board
Investors · 10
Also in the syndicate · 2
Reported raises · per SEC filings
Form D private placements$68.4M disclosed across 3 of 4 rounds · 2020–2021
▶$50MraisedDec 2021 · 21 investors · OtherRule 506(b)
- Greg YapDirector
- Zack GrayExecutive Officer, Director, Promoter
- Mattan GriffelExecutive Officer, Director, Promoter
- Offering amount
- $50M
- Amount sold
- $50M
- First sale
- Dec 2021
- Incorporated
- Corporation, Delaware, 2018
- Federal exemptions
- 06b
▶$15MraisedApr 2021 · 19 investors · OtherRule 506(b)
- Zack GrayExecutive Officer, Director, Promoter
- Greg YapDirector
- Mattan GriffelExecutive Officer, Director, Promoter
- Offering amount
- $15M
- Amount sold
- $15M
- First sale
- Apr 2021
- Incorporated
- Corporation, Delaware, 2018
- Federal exemptions
- 06b
▶$3.4MraisedMay 2020 · 27 investors · OtherRule 506(b)
- Mattan GriffelExecutive Officer, Director
- Zack GrayExecutive Officer, Director, Promoter
- Offering amount
- $3.4M
- Amount sold
- $3.4M
- First sale
- Apr 2020
- Incorporated
- Corporation, Delaware, 2018
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
The YC application· Winter 2020 batch
Company profile
researched Aug 2026Ophelia (legal name Ophelia Health Inc.) is a New York City-based digital health provider that delivers medication-assisted treatment (MAT) for opioid use disorder through telemedicine. Patients enroll online, meet a dedicated clinical care team over Zoom video visits, and, if eligible, receive a prescription for Suboxone (buprenorphine plus naloxone) or its generic equivalent sent to a local pharmacy. Beyond the core medication, clinicians can prescribe comfort medications for withdrawal symptoms such as nausea and insomnia and treat commonly co-occurring conditions including depression and anxiety [0][2][3].
The care model is built around removing the barriers associated with residential rehab: no travel, no mandatory groups or 12-step attendance, appointments available seven days a week, and an intake process the company says results in being seen within one to three days. Care teams combine clinicians, nurses, care coordinators, enrollment coordinators and peers; triage nurses provide round-the-clock clinical support. Visit cadence is weekly during the first month of stabilization, biweekly thereafter, and monthly after roughly three months [0][2][3].
Clinically, the company describes a digitally native model adapting the Massachusetts Collaborative Care Model to telemedicine, with synchronous video visits, FDA-approved medications, urine drug screens, on-demand messaging, optional groups, and care coordination. Ophelia was co-designed by addiction psychiatrists Dr. Arthur Robin Williams (Chief Medical Officer) and Dr. Adam Bisaga (Senior Medical Director), both academic researchers at Columbia University / New York State Psychiatric Institute [4][5].
Compiled by commissioned research from 8 cited public sources — announcements, filings, and press listed under research sources below.
Key figures
latest reportedCompany-reported or press-reported figures, each dated to when it was claimed — not independently audited.
Founder mafia
4 people who came through Ophelia went on to found or lead other companies.
Competitors · 2
by search overlapCompanies competing with Ophelia for the same Google search keywords, organic and paid, via search-intersection analysis.
Timeline · 6
launches, deals, and filingsBy the time of the Series B, Ophelia reported expansion to 27 states and payer contracts covering 75 million lives across Medicare, Medicaid and commercial plans.
Ophelia Health Inc. announced a $50 million Series B led by Tiger Global Management, with participation from Good Friends, Menlo Ventures, General Catalyst, Refactor Capital, 640 Oxford Ventures, Interplay Ventures and PillPack co-founder Elliot Cohen. Proceeds were earmarked for U.S. expansion, payer and partner integrations, and a clinician recruitment and retention platform.
$50M source ↗
$15M source ↗
Press coverage referenced on Ophelia's site describes the YC-backed company raising $2.7 million to help people quit opioids without rehab.
$2.7M source ↗
Ophelia is listed as a Y Combinator Winter 2020 company in the Mental Health Tech, Healthcare and Telemedicine categories.
Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.
Legal entities · 1
corporate structureIn the news
▸Research sources · 8
primary sources listed
- Opheliaophelia.com · web
8 public sources were cited for this profile; the first-party ones are listed here.
Frequently asked questions
- What does Ophelia do?
- Telemedicine provider of medication-assisted treatment (Suboxone) for opioid use disorder, delivered to patients at home.
- Who founded Ophelia?
- Ophelia was founded by Mattan Griffel, Zack Gray in 2019.
- Who are Ophelia's investors?
- Ophelia's investors include Menlo Ventures, Y Combinator, Four Acres Capital, Good Friends, General Catalyst, Interplay Ventures Early Stage Management Llc, Refactor Capital, Tiger Global Management.
- How much funding has Ophelia raised?
- Ophelia has disclosed $68.4M raised across 3 of its 4 known rounds.
- Where is Ophelia headquartered?
- Ophelia is headquartered in New York City, US.




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