/Investor DB

OphthaFund

Venture capital

Charleston · Pre-Seed–Series A

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Investment thesis

The firm leverages deep expertise in ophthalmology and biotechnology to invest in specialized companies within these sectors. The team provides value-add support through drug development knowledge and access to a network of investors, partners, and subject matter experts.

Source: firm website, verified Aug 7, 2026.

Stage
Pre-Seed–Series A
HQ
Charleston, SC, US
Leads rounds
Leads
Instruments
Equity
Tracked investments
11

What they invest in

from 6 of 11 portfolio companies

Biotech ×6Medical Devices ×4Healthtech ×2Deep Tech ×1Digital Health ×1

HQs:United States×5Switzerland×1

Investments · 11 tracked

founders shown can be your intro path
Forwardvue Pharmaforwardvuepharma.comin

ForwardVue Pharma develops a long-acting ORAI1 blocker administered by intravitreal injection to treat retinal neovascular disease, with a target dosing of 1-2 injections per year for durability up to 12 months.

BiotechHealthtechMedical DevicesMobile, US

Alan Franklin(Ophthalmologist, Vitreoretinal Diseases and Surgery)inRAJ MATURI(Director)NEIL DONNENFELD(Director)RUBEN TIMMONS(Director)BARRY BUTLER(Director)AMIR SHOJAEI(Director)

PartnerTom Mather· solo GP

Implicit Bioscienceimplicitbioscience.comin𝕏

Implicit BioScience develops therapeutic approaches targeting cardioimmunology, specifically using CD14 blockade to modulate immune responses in acute heart attack (STEMI) treatment.

BiotechDeep TechMedical DevicesSeattle, US

Garry Redlich(CEO & MD, Co-founder)inProf. Peter Andrews(Chairman, Co-founder)James Edward Rottsolk(Executive Officer, Director)Marion Koster(Chief Financial Officer and Company Secretary)inBrian William Ziegelaar(Executive Officer)

BoardDaniel David Syrdal(Director)

PartnerTom Mather· solo GP

Mcal Therapeuticsmcaltherapeutics.net

Biotechnology company developing treatments for ophthalmic diseases, focusing on dry eye through a topical ophthalmology platform.

BiotechSan Francisco, US

Tom Gadek(Founder)inChristopher J. Murphy(Director)Charles O'Neill(Executive Officer, Director)Tanya Shnaydman(Executive Officer)

PartnerTom Mather· solo GP

ONL Therapeuticsonltherapeutics.comin

ONL Therapeutics is a clinical-stage biopharmaceutical company developing therapies to preserve sight by preventing Fas-mediated death of retinal cells, a cause of vision loss and blindness.

BiotechHealthtechMedical DevicesAnn Arbor, US

David Zacks(Co-Founder & Chief Scientific Officer)inDavid Esposito(Executive Officer, Director)inConstance Chang(Executive Officer)John K Freshley(Executive Officer, Director)inJeffrey A Jamison(Executive Officer)in

BoardAaron Fletcher(Director)in

PartnerTom Mather· solo GP

Co-investorsExSight VenturesInvest MichiganNovartis Venture FundVisionary VenturesBios PartnersInFocus Capital Partners, LLC+3 more

Premark Pharmapremarkpharma.comin

Premark Pharma develops therapeutic candidates for ophthalmologic conditions including blepharitis and dry eye disease.

BiotechDigital HealthMedical Devices

PartnerTom Mather· solo GP

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Advanced Liquid LogicAllysta PharmaceuticalsBlink CNSElucida OncologyEncore PharmaceuticalsMyze

Frequently asked questions

How many investments has OphthaFund made?
OphthaFund has 11 tracked investments.
What stage does OphthaFund invest at?
OphthaFund invests at the Pre-Seed, Seed, Series A stages.
What sectors does OphthaFund focus on?
OphthaFund focuses on Biotech, Healthtech, Medical Devices.
Where is OphthaFund located?
OphthaFund is headquartered in Charleston, US.
Does OphthaFund lead rounds?
Yes, OphthaFund leads investment rounds.
Who does OphthaFund co-invest with?
OphthaFund most often shares deals with ExSight Ventures, Invest Michigan, Michigan Capital Network, among 6 tracked co-investors.

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