Mental Health Startups

Polaris Genomics is a Veteran-owned biotech startup mapping molecular biomarkers to develop objective, biologically-based diagnostics and novel therapeutics for mental health and neuropsychiatric conditions such as PTSD. It combines genomics and AI to advance precision mental health care.

3 investors

Precise Behavioral provides virtual behavioral health services and a hybrid AI-driven care platform for health systems, health plans, and provider groups, with a focus on helping hospitals address challenges such as emergency department boarding. It offers clinician-driven virtual mental health programs, licensed providers across all 50 U.S. states, and revenue cycle management support.

3 investors

Presence provides teletherapy and remote assessment solutions for K-12 school districts, connecting them with a nationwide network of licensed SLPs, OTs, psychologists, and social workers to deliver special education services. Its platform offers 60+ assessments and 10,000+ therapy materials to help schools meet IEP requirements amid provider shortages.

3 investors

Prosper Health is a telehealth platform providing psychological assessment and therapy services, with a focus on supporting neurodivergent and autistic adults. The platform connects clients with licensed psychologists, clinical social workers, and licensed therapists across multiple states who specialize in neurodiversity-affirming care.

3 investors

Psyomics builds behavioral health assessment tools, including beseen™, which captures structured data and free text from patients, families, and professionals to support clinical pathways for adults and young people. The company is also developing a dry blood spot biomarker test to distinguish Major Depressive Disorder from Bipolar disorder to reduce misdiagnosis.

3 investors

Psyon Games develops video games designed to support mental health and well-being, targeting healthcare markets and the life science industry. The company combines gaming expertise with clinical knowledge in areas such as ADHD and mental health.

3 investors

Puramente is a wellness and personal development platform offering self-paced courses, live group sessions, audiobooks, and in-person retreats across Latin America focused on meditation, emotional regulation, and personal transformation.

3 investors

Radial provides mental health care through a team-based, concierge-style approach using evidence-based and newer rapid-acting treatments for conditions like depression, trauma, and OCD. The service combines psychiatry, therapy, and care navigation to simplify access to mental health treatment.

3 investors

Reset Pharma is a CNS-focused pharmaceutical company developing psilocybin and related psychedelics for the treatment of mental illness in patients with life-threatening diseases. It holds an exclusive worldwide license from NYU Langone Health for related intellectual property.

3 investors

Reviving Mind provides a healthcare platform that connects individuals with healthcare professionals and leverages collaborative care models for mental health and wellness. The company serves patients seeking well-being support across various mental health and sleep disorders.

3 investors

Sage Haven is a parental control app for messaging and calling that allows parents to approve all contacts and uses AI to block harmful messages before they reach children. It works across iMessage and Google Messages, enabling safer communication with trusted friends and family while reducing exposure to bullying and inappropriate content.

3 investors

Sayana is a mental wellness app that helps users manage stress, anxiety, and sleep through daily mood check-ins and personalized therapeutic practices. The app serves individual consumers and workplace teams globally.

3 investors

Sehat Kahani provides mental health consultations and well-being services through a digital platform connecting consumers and corporate clients with licensed psychiatrists and psychologists. The company operates across consumer apps, corporate wellness programs, and low-income community partnerships.

3 investors

Selia is an online mental health platform offering therapy sessions with certified psychologists and therapists in Latin America. The platform provides personalized therapist matching, structured programs for anxiety, depression, burnout and relationship issues, and complementary wellness features including assessments, meditation, and coaching.

3 investors

Senseye develops technology and tools for detecting and treating PTSD, leveraging neuroscience research and machine learning. The company serves mental health practitioners and trauma patients in the healthcare sector.

3 investors

Serenis is an online mental health platform offering video sessions with vetted psychologists, psychotherapists, psychiatrists, coaches, and nutritionists, covering individual, couples, ADHD, psychiatry, sexology, and eating-disorder care. It serves individuals in Italy (including Italians living abroad) and companies that provide the service to their employees.

3 investors

A platform providing peer support services. The company focuses on building safe and reliable community-based support networks.

3 investors

Sincrolab offers a personalized digital treatment to improve attention and focus in children, delivered at home through a gamified app (Sea of Heroes) with daily 15-minute activities and professional supervision. It targets families whose children struggle with concentration and task completion, providing online evaluation and ongoing clinical follow-up over a six-month program.

3 investors

Solace Care is a digital platform for end-of-life planning and bereavement support that helps individuals and families prepare for loss, navigate the practical and emotional aftermath of death, and access guided support through insurance and employer partnerships. The company operates across the Nordic countries.

3 investors

Sooma Medical develops and manufactures transcranial direct current stimulation (tDCS) devices for treating major depressive disorder, fibromyalgia, and chronic neuropathic pain without medication. The company serves clinics, hospitals, and universities globally through neuromodulation technology approved for clinical use and research.

3 investors

Spectrum.Life provides integrated digital health and wellbeing services to organizations and their employees, covering medical care, mental health support, and personalized coaching. The platform serves employers, educational institutions, and healthcare systems seeking comprehensive health management solutions for their populations.

3 investors

Spill provides workplace mental health support by letting employees book video therapy sessions through Slack, MS Teams, and web app integrations, and offers Safety Net, a survey tool that flags at-risk team members for outreach by counsellors. It sells to businesses, initially UK tech companies and later a wider range of industries and global clients.

3 investors

TARA Mind offers a specialized, clinician-guided mental health benefit that employers add to their existing benefits to serve workers with treatment-resistant conditions, connecting them to a vetted U.S. network of therapists and physicians for evidence-based care. The company uses diagnostics, access to advanced treatments, and outcomes monitoring to reduce avoidable healthcare utilization and lower employer medical costs.

3 investors

Bea Arthur's personal brand website promoting her upcoming book "How To Make Confidence and Capitalism Work for You" (Coming 2026). The site documents her career in mental health technology and media, including her founding of The Difference, an Alexa Skill for therapy access.

3 investors