Mental Health Startups

neurocare group operates a network of over 20 clinics across Europe, the United States, and Australia offering personalized mental health treatments such as TMS, neurofeedback, and tDCS for conditions including depression, ADHD, OCD, and sleep disorders. It also provides a Digital Therapy Platform and an online academy that trains third-party clinicians in its treatment protocols.

2 investors

Neurode develops a wearable neurostimulation headband paired with a companion app that provides personalized insights and recommendations from psychologists, neuroscientists, and engineers. The device uses clinical-grade stimulation pads and targets adults in the US managing mental health and neurological wellness.

2 investors

NeuroFlow provides behavioral health risk analytics, engagement, and referral infrastructure that use machine learning on claims, EHR, ADT, and assessment data to identify and stratify behavioral health needs across populations. It serves payors, health systems, and the federal government to connect members and patients to appropriate care and measure outcomes for cost control and quality performance.

2 investors

nilo offers workplace mental health support, connecting employees and leaders with psychologists for sessions, coaching, roundtables, and digital exercises. It sells to companies as a benefit aimed at improving company culture, engagement, and talent retention.

2 investors

Qualifacts provides AI-powered electronic health record (EHR) software, data tools, and interoperability services for behavioral health agencies, both non-profit and for-profit. Its offerings support clinical documentation, workflow automation, data insights, and secure data exchange for clinicians and administrators across the United States.

2 investors

Opya provides early intervention ABA (applied behavior analysis) therapy for young children diagnosed with autism and their families. It operates as an accredited autism care provider in California.

2 investors

OurRitual offers an alternative to traditional couples therapy, combining live sessions with licensed relationship experts and an app with guided exercises, educational content, and an AI assistant. It serves individuals and couples seeking relationship support through personalized pathways.

2 investors

Outro is a telehealth program that pairs patients with a dedicated clinician to safely taper off antidepressants using the evidence-based hyperbolic tapering method, including compounded doses, symptom monitoring, and between-visit support. It serves individuals in the United States looking to reduce or stop psychiatric medications, and plans to expand to benzodiazepines and gabapentinoids.

2 investors

oVRcome is a VR-based platform that provides clinicians with pre-built exposure pathways and a library of 360° real-life VR experiences to support exposure-based therapy for anxiety-related conditions and avoidance behaviours. It serves licensed mental health professionals, from sole practitioners to large clinics, with clinician-controlled content, engagement insights, and workflow tools for both in-session and remote care.

2 investors

OYE is a wellness app offering guided routes, meditations, and yoga practices led by guides to help users connect with their emotions and improve mental and emotional health. The content is delivered in Spanish for a Spanish-speaking audience.

2 investors

Paired is a mobile app for couples offering daily check-ins, quizzes, and games developed with relationship experts to help partners communicate and stay connected. It targets busy couples seeking to improve their relationships and intimacy.

2 investors

Palo Santo is a venture capital firm that invests in neuroscience companies developing therapeutics and technologies for mental health, including next-generation psychedelic medicines and novel CNS targets. Its portfolio spans psychedelic pharmaceuticals, AI-driven neurotechnology, and synaptic biology research.

2 investors

Peekapak provides a social-emotional learning (SEL) curriculum for K-12 schools, including levelled readers, planned lessons, professional development, and a digital learning game called myPeekaville. Aligned to CASEL's five SEL competencies, it serves elementary through high school students and gives teachers tools to track student progress and engagement.

2 investors

PeopleOne Health is a value-based primary care provider offering physical and mental health prevention and treatment services through employer-funded health centers. It serves employers, brokers, and their employees with primary care that reduces healthcare costs and eliminates member copays, deductibles, and coinsurance.

2 investors

Pery is a SaaS platform that integrates behavioral health into clinical workflows by automating patient-reported outcomes, AI-driven analytics, and care coordination. It continuously monitors patients between visits and connects with EHRs to support provider decision-making for clinics offering mental health services.

2 investors

Polaris Genomics is a Veteran-owned biotech startup mapping molecular biomarkers to develop objective, biologically-based diagnostics and novel therapeutics for mental health and neuropsychiatric conditions such as PTSD. It combines genomics and AI to advance precision mental health care.

2 investors

Waffle provides a group journaling platform designed to help users form closer human connections and address loneliness and social isolation. The service draws on a century-old Japanese practice of group journaling to foster genuine relationships and community bonding.

2 investors

Poppy Seed Health offers an app that connects pregnant and postpartum people, and those experiencing pregnancy loss, to a network of doulas, midwives, and nurses via on-demand text chat. It provides emotional and mental health support through a membership or pay-per-chat model, with access to a library of evidence-based resources.

2 investors

Predictably Human is developing NoMore, an adaptive drug delivery device paired with a personalized digital companion, aimed at patients with mental health conditions, addiction, and other complex disorders. The system is intended to support an ecosystem of digital products and services around treatment.

2 investors

Promentis Pharmaceuticals is a privately-held biopharmaceutical company developing oral compounds targeting the System xc- glutamate pathway to treat neuropsychiatric disorders. Its lead indication is trichotillomania, and its work extends to other obsessive-compulsive, addictive, and CNS conditions.

2 investors

Psilera is a biotech company developing neuroscience-focused therapeutics, including its lead asset PSIL-006, described as next-generation mindful medicine.

2 investors

Psych Hub is a clinical skill development platform for behavioral health, offering evidence-based, trauma-informed education, portable credentials, and applied-skill practice for mental health clinicians. It works with payers, provider organizations, and professional associations to define and certify a national quality standard for behavioral health care.

2 investors

Psygen is a contract development and manufacturing organization (CDMO) producing psychedelic and neuroplastogen active pharmaceutical ingredients such as LSD, MDMA, and psilocybin, and offering CMC services. It supplies these APIs to research and humanitarian projects, including donations through Canada's Special Access Program.

2 investors

Pulse is a smart wearable ring paired with a mobile app that delivers gentle micro-vibrations to remind users to pause, breathe, and practice mindfulness throughout the day, including headphone-free guided meditation. It also offers expert-led self-development courses and a Pulse+ subscription with additional modes for habit-building and digital detox.

2 investors