Medical Devices Startups

Endospan develops endovascular stent graft systems, including the NEXUS Multi-Branch Aortic Arch Stent Graft System, for repairing aortic aneurysms and dissections in patients whose anatomy is unsuitable for traditional EVAR/TEVAR therapy. The company operates in the medical device sector, serving the endovascular aortic repair market.

2 investors

Endostart develops and manufactures medical devices for gastrointestinal endoscopy, aimed at healthcare sector professionals. Founded in 2018, the company operates in the medical device industry.

2 investors

Endo Tools Therapeutics develops endoscopic medical devices for incisionless treatment of gastric conditions, including obesity, allowing gastroenterologists to perform endoscopic suturing through a natural orifice. Its devices target physicians and are used in Europe, with CE marking for endoscopic gastroplasty and FDA clearance for tissue approximation.

2 investors

enGene is a genetic medicine company developing drug therapies across oncology, urology, and other therapeutic areas, with a focus on patient outcomes.

2 investors

Enlitic provides artificial intelligence solutions for healthcare systems to improve medical imaging data quality and unlock new revenue opportunities. The company's intelligent data framework enhances data quality, orchestrates workflows, and enables better comprehension of imaging archives.

2 investors

Enspire DBS is conducting a clinical trial evaluating Deep Brain Stimulation combined with physical therapy (DBS + Rehab) to assess safety and whether it can improve arm function in stroke patients with lasting impairment. The company develops an investigational neurostimulation device for post-stroke rehabilitation.

2 investors

Eon Aligner manufactures clear dental aligners and provides treatment planning services to dentists, operating primarily in the MENA region. The company serves orthodontists with direct-to-doctor solutions including pre-approved treatment plans and clinical support.

2 investors

EOS Imaging provides imaging solutions for medical facilities and hospitals to support patient treatment. The company serves healthcare providers globally.

2 investors

EPICS Therapeutics develops RNA epigenetics-based cancer treatments, focusing on METTL3 inhibitors for cancers including non-small cell lung cancer, pancreatic cancer, ovarian cancer, and colorectal cancer where existing therapies are insufficient.

2 investors

Epion Therapeutics is developing EpiSmart, a minimally-invasive corneal cross-linking system to treat keratoconus and corneal ectasia without disrupting the epithelium. The treatment targets patients with ectatic corneal disease as an early-intervention standard of care.

2 investors

Epitomee develops ingestible capsule-based therapies that deploy in specific regions of the stomach, duodenum, and small intestine to provide mechano-sensory stimulation, targeted drug delivery, and absorption management before dissolving and passing naturally. The company partners with pharmaceutical and industry companies to commercialize these therapeutic applications.

2 investors

Epsilon partners radiologists with advanced technology to address the radiology shortage in the US and improve diagnostic accuracy and speed. The company combines human expertise with AI to reduce delays in medical imaging, which accounts for 75% of medical decisions.

2 investors

Clario provides endpoint technologies and software for clinical trial management, serving pharmaceutical and biotech sponsors, CROs, and clinical trial sites globally. The platform combines imaging analysis, electronic clinical outcome assessments, cardiac safety monitoring, and AI-powered solutions to support site-based, hybrid, and decentralized clinical trials.

2 investors

eSight makes a wearable, hands-free digital device that uses a camera and image-processing algorithms to enhance sight for people with central vision loss and legal blindness caused by more than 20 eye conditions. The product offers features such as zoom, contrast, and color filters to help users read, recognize faces, watch TV, and maintain mobility, and it includes a personal coaching program for setup and support.

2 investors

EsoCap is developing a smart drug delivery platform for long-lasting, targeted topical therapy of the esophagus, designed to increase mucosal contact time and drug deposition. Its lead candidate ESO-101 is being developed to treat patients with eosinophilic esophagitis (EoE).

2 investors

Esperto Medical is a medical device company developing compact, sensor-based diagnostic and monitoring technology, drawing on expertise in electrical engineering, imaging, and machine learning. Its work targets continuous physiological monitoring, including blood pressure sensing, for healthcare applications.

2 investors

Esphera designs transgenes that enable budding exosomes to carry multimeric proteins for therapeutic applications, with initial focus on modifying tumor-derived exosomes to create immunostimulatory cancer vaccines.

2 investors

Ethicon develops surgical products and technologies including wound closure, hemostats, surgical stapling, surgical energy, antimicrobial dressings, and surgical instruments, along with clinical education programs for surgeons. Part of Johnson & Johnson MedTech, it serves clinicians and healthcare providers across specialties such as bariatric, cardiovascular, colorectal, gynecology, orthopaedic, and thoracic surgery.

2 investors

EurekaBio develops technologies and solutions for the cell and gene therapy (CGT) industry, focused on treatments for diseases such as cancer, rare diseases, genetic disorders, and auto-immune conditions. The company positions itself as a provider of comprehensive, research-driven solutions to CGT challenges.

2 investors

Evolve Biosystems develops probiotic strains of B. infantis, including EVC001 and a next-generation drug strain INF108, aimed at supporting the infant gut microbiome and preventing necrotizing enterocolitis (NEC) in premature infants. The company works at the intersection of breast milk research and infant health in the biotech and digital/medical therapeutics space.

2 investors

Exact Sciences develops diagnostic tests for cancer, including tests that assess hereditary risk, screen for the presence of cancer, and analyze the genomic alterations of a diagnosed cancer to inform treatment decisions. Its products serve patients and clinicians in oncology diagnostics.

2 investors

Exeliom Biosciences is a biotechnology company developing biotherapies, with work in areas such as inflammatory bowel disease (Crohn's and colitis). The company's projects have been supported by public and non-profit funding programs.

2 investors

Exero Medical develops the xBar system, which uses electrode sensors embedded in a standard surgical drain to non-invasively monitor post-operative tissue healing and detect anastomotic leaks after gastrointestinal surgery. The system provides healthcare providers with post-operative data to enable earlier detection of complications; it is currently limited to investigational use in the US.

2 investors

Eximis Surgical develops a minimally invasive specimen removal device for use in abdominal surgery, enabling surgeons to remove surgical specimens through small incisions rather than requiring larger incisions at the end of procedures. The device targets patients undergoing minimally invasive surgical procedures to reduce postoperative pain and recovery time.

2 investors