Medical Devices Startups

BrainsGate develops a neurostimulation therapy for stroke patients based on stimulation of the sphenopalatine ganglion (SPG) to increase cerebral blood flow. The company operates in the medical device field, having conducted the ImpACT-24 clinical studies for acute ischemic stroke treatment.

2 investors

BrainSpec develops software for analyzing and visualizing MR spectroscopy (MRS) neuroimaging data, aiming to make a non-invasive "virtual biopsy" available to clinicians and researchers. Its technology targets patient populations with conditions such as brain tumors, Alzheimer's disease, and Multiple Sclerosis.

2 investors

Miist develops inhaled microparticle therapeutics that deliver medicine to the bloodstream in 30 seconds, targeting conditions like migraine, pain, and anxiety where rapid onset is critical. The company is advancing a portfolio of systemic therapies starting with MST-02, a migraine treatment designed to work significantly faster than existing oral medications.

2 investors

Brinter develops 3D bioprinting technology for regenerative implants. The company serves the medical and biotech industries focused on human repair applications.

2 investors

Hyperion Biosystems builds diagnostic devices that use computer vision and physics-based algorithms to improve the sensitivity and specificity of point-of-care and at-home tests. Its products include the HALO platform and Helios, a rapid molecular diagnostic platform combining padlock probe chemistry, isothermal amplification, and optical readout for multiplexed, single-copy detection.

2 investors

CALCIVIS develops the CALCIVIS Imaging System, a chairside diagnostic device that provides real-time assessment of enamel demineralization and tooth decay activity to support preventive dentistry. The FDA-approved and UKCA-marked system is aimed at dental clinicians managing caries and erosion.

2 investors

Canopy Biosciences (Bruker Spatial Biology) develops spatial biology instruments and assays for analyzing gene expression, RNA, and proteins in tissue samples. The company serves research institutions, academic medical centers, and clinical laboratories studying oncology, biomarker discovery, and disease mechanisms.

2 investors

Capstan Medical develops surgical robotics combined with catheter-based technology and next-generation implants to repair and replace heart valves. Its minimally invasive approach targets structural heart disease, including mitral and tricuspid valve conditions, as an alternative to open heart surgery.

2 investors

Philips Capsule provides healthcare informatics solutions for hospitals and health systems, including medical device integration, system integration, cloud data storage and analytics, clinical surveillance, patient data management, and virtual care. Now part of the Philips Acute Care Informatics portfolio, its vendor-neutral platform connects live data from over 1,200 medical devices to more than 100 clinical systems.

2 investors

CardiacBooster is a medical device company developing a high-flow, low-profile percutaneous ventricular assist device (pVAD) for temporary cardiac support in patients with cardiogenic shock and those undergoing high-risk coronary procedures (high-risk PCI). It is a spin-off from Radboud University Medical Center, with offices in Galway, Ireland and Nijmegen, Netherlands.

2 investors

Cardiva Medical, part of Haemonetics, develops the VASCADE family of vascular closure systems, including venous and arterial closure devices used in cardiovascular procedures. It is part of a medical technology company serving hospitals and blood collection centers with blood management, plasma collection, hemostasis analysis, and vascular closure products.

2 investors

Castle Creek Biosciences develops re-dosable gene therapies for genetic diseases, with a lead candidate (D-Fi) in registrational clinical trials for dystrophic epidermolysis bullosa.

2 investors

Catalyst OrthoScience develops medical devices and surgical techniques for shoulder replacement procedures, including total shoulder replacements and reverse shoulder arthroplasty. The company serves orthopedic surgeons and hospitals aiming to improve patient outcomes and surgical efficiency.

2 investors

CaTe develops technology-enabled healthcare solutions that help patients continue necessary medical care in their daily lives after hospital discharge. The company combines medical expertise with IoT, AI, and digital tools to support ongoing treatment adherence and patient monitoring, particularly for cardiac care and post-discharge recovery.

2 investors

Cayuga Biotech develops first-in-class therapeutics to control life-threatening hemorrhage and treat bleeding disorders, targeting cases such as noncompressible hemorrhage and coagulation dysfunction from blood thinners. The company applies proprietary biomimetic science based on the body's natural clotting mechanisms.

2 investors

CDL Nuclear provides Cardiac PET/CT and SPECT MPI imaging services and end-to-end solutions for independent cardiologists and hospitals. Its offering supports physicians in diagnosing and managing cardiac disease.

2 investors

Cebiotex is a biotechnology company developing local therapies for oncology using proprietary nanofiber engineering to deliver anti-tumor agents directly at surgical sites. The company aims to reduce cancer recurrence and improve outcomes in surgical oncology.

2 investors

Celaid Therapeutics develops hematopoietic stem cell expansion technology, including a method to replace albumin with polyvinyl alcohol and to expand human hematopoietic stem cells ex vivo in large quantities. The company applies this technology to stem cell transplantation and gene therapy for blood cancers such as leukemia and other blood and genetic diseases.

2 investors

Celcuity is a commercial-stage biotechnology company developing targeted cancer therapies for tumors involving the PAM (PI3K/AKT/mTOR) pathway, including breast, prostate, lung, endometrial, colon, and ovarian cancers. Its lead candidate, gedatolisib, targets all Class I PI3K isoforms and the mTORC1 and mTORC2 complexes and is being evaluated across multiple oncology clinical programs.

2 investors

Cell Microsystems develops automated instruments for cellular and molecular workflows used in life science research, including oncology, stem cell biology, and regenerative medicine. Its products support scientists in laboratory research and single-cell isolation and analysis.

2 investors

CellCentric is a clinical-stage biopharmaceutical company developing inobrodib, an oral small molecule inhibitor of the p300/CBP proteins, for the treatment of multiple myeloma and other cancers. The drug is being evaluated in clinical trials, including in combination with standard-of-care therapies for use in community care settings.

2 investors

CellFiber develops cell mass-production technology for cell and gene therapy, including ZeitoTM Plus, a GMP/GCTP-compliant cell fiber manufacturing device designed for fiber culture that enables aseptic, closed seeding of fiber-encapsulated cells directly into culture bags. It serves the GMP cell manufacturing and cell/gene therapy industry.

2 investors

Cellphire Therapeutics develops platelet-based and freeze-dried cellular therapeutics for transfusion medicine, focused on controlling hemorrhage. Through its veterinary subsidiary BodeVet, it also markets freeze-dried platelet products for companion and exotic animals.

2 investors

CellSonics develops SimpleFlow, an instrument that uses acoustic waves rather than enzymes to dissociate tissue into single cells, aiming to release more cells without bias. It is used in life sciences applications such as single-cell RNA sequencing, demonstrated on mouse brain tissue with higher preservation of astrocytes and neurons.

2 investors