/Companies

Castle Creek Biosciences

Exton, US · Founded 2018 · Delaware corporation · 25 employees on LinkedIn · 4 known investors

Find your way into Castle Creek Biosciences

580 people in our graph share verified history with the Castle Creek Biosciences team — schools, employers, funds. One of them is your warm intro.

Kavita Björkdahlunlockedknows Matthew Gantz · together at Swedish Orphan Biovitrum (overlapped)
knows the team · via BTG
knows the team · via Chiron Corporation (now Novartis)
×6knows the team · via United States Marine Corps
×2knows the team · via Hydra Biosciences
knows the team · via Swedish Orphan Biovitrum

Castle Creek Biosciences develops re-dosable gene therapies for genetic diseases, with a lead candidate (D-Fi) in registrational clinical trials for dystrophic epidermolysis bullosa.

Founders & leadership

MGMatthew Gantz
Matthew GantzPresident and Chief Executive OfficerHe brings over 20 years of experience leading specialty biopharmaceutical and medical device companies.
DCDavid Chu
David ChuFounder
MTMichael Townsley
Michael Townsley
CJChristopher J. Larson
Christopher J. LarsonChristopher J. Larson has spent 25+ years in quality control and laboratory operations across cell and gene therapy, biologics, and oncology manufacturing, leading teams of 60+ scientists and scaling laboratory operations from early-stage clinical through commercial production. He previously held positions at SK Pharmteco/CBM and Endo Pharmaceuticals supporting CAR-T, AAV, lentiviral and adenoviral vector programs, and earlier contributed to development of an FDA-cleared circulating tumor cell enumeration assay that generated a US patent and a cited publication.
RWRhea Williams
Rhea WilliamsRhea Williams has spent over 30 years in regulatory affairs and quality assurance across pharmaceutical and biotechnology, including leadership roles in regulatory strategy at biotech companies and founding Secord Inc., a regulatory and quality assurance consulting firm, in 2000. Her experience spans global drug development from small molecules to gene and cell therapies, with particular focus on rare disease and oncology programs, and direct engagement with the FDA, EMA, and other regulatory agencies.
JS
Jude SullivanExecutive
DP
Darien ParhadExecutive
MD
Michael DerbyChief Executive Officer
TC
Timothy CunniffNamed on SEC filing

Board

MCMatthew Crabtree
Matthew CrabtreeBoard director
DB
David BrillBoard director
JA
Jeffrey AroninBoard director

Investors · 4

Reported raises · per SEC filings

Form D private placements

$839.8M disclosed across 6 rounds · 2018–2025

▶$75MraisedFeb 2025 · 30 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • David BrillDirector
  • Matthew CrabtreeDirector
  • Jeffrey AroninDirector
  • Matthew GantzExecutive Officer, Director
  • Patrick MorrisDirector
  • Jude SullivanExecutive Officer
  • Darien ParhadExecutive Officer
  • Antonio GraciasDirector
Offering amount
$75M
Amount sold
$75M
Sales commissions
$2.8M
Placement agents
Paragon Health Capital, LLC
First sale
Feb 2025
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$112.8MraisedMay 2022 · 54 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Mark GrafDirector
  • Matthew J. GantzExecutive Officer, Director
  • W. Bradford MiddlekauffExecutive Officer
  • Mary SpellmanExecutive Officer
  • Jeffrey S. AroninDirector
  • Patrick J. MorrisDirector
  • Antonio GraciasDirector
Offering amount
$112.8M
Amount sold
$112.8M
Sales commissions
$1.7M
Placement agents
Paragon Health Capital, LLC
First sale
Apr 2022
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$11.8MraisedFeb 2022 · 6 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Jeffrey S. AroninDirector
  • W. Bradford MiddlekauffExecutive Officer
  • Matthew J. GantzExecutive Officer, Director
  • Mark GrafDirector
  • Patrick J. MorrisDirector
  • Antonio GraciasDirector
  • Babar GhiasExecutive Officer
  • Mary SpellmanExecutive Officer
Offering amount
$11.8M
Amount sold
$11.8M
Sales commissions
$625K
Placement agents
Paragon Health Capital, LLC
First sale
Jan 2022
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$25MraisedJul 2021 · 36 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Matthew J. GantzExecutive Officer, Director
  • Mary SpellmanExecutive Officer
  • Gregory MacMichaelExecutive Officer
  • Gregory WujekExecutive Officer
  • Antonio GraciasDirector
  • W. Bradford MiddlekauffExecutive Officer
  • Patrick J. MorrisExecutive Officer, Director
  • Jeffrey S. AroninDirector
Offering amount
$25M
Amount sold
$25M
Sales commissions
$625K
Placement agents
Paragon Health Capital, LLC
First sale
Jun 2021
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$54.6MraisedJan 2020 · 12 investors · Pharmaceuticals
Rule 506(b)
Officers, directors & promoters on the filing
  • Jeffrey S. AroninDirector
  • Gregory WujekExecutive Officer, Director
  • Patrick J. MorrisExecutive Officer, Director
  • Timothy M. CunniffDirector
  • Antonio J. GraciasDirector
Offering amount
$54.6M
Amount sold
$54.6M
Minimum investment
$82.4K
Sales commissions
$710K
Placement agents
Paragon Health Capital, LLC
First sale
Dec 2019
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$560.5MraisedOct 2018 · 19 investors · Pharmaceuticals
Rule 506(b)
Officers, directors & promoters on the filing
  • Jeffrey AroninDirector
  • Michael DerbyExecutive Officer, Director
  • Antonio GraciasDirector
  • Patrick MorrisExecutive Officer, Director
  • Timothy CunniffDirector
Offering amount
$560.5M
Amount sold
$560.5M
Sales commissions
$1.2M
Placement agents
Octagon Capital Group, LLC
First sale
Oct 2018
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

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In the news

Frequently asked questions

What does Castle Creek Biosciences do?
Castle Creek Biosciences develops re-dosable gene therapies for genetic diseases, with a lead candidate (D-Fi) in registrational clinical trials for dystrophic epidermolysis bullosa.
Who are Castle Creek Biosciences's investors?
Castle Creek Biosciences's investors include Paragon Biosciences LLC, Valor Equity Partners, Fidelity Investments, Horizon.
How much funding has Castle Creek Biosciences raised?
Castle Creek Biosciences has disclosed $839.8M raised across 6 rounds.
Where is Castle Creek Biosciences headquartered?
Castle Creek Biosciences is headquartered in Exton, US.