Medical Devices Startups

Cionic develops the Neural Sleeve, an FDA-cleared wearable device that uses electrical muscle stimulation to improve walking and mobility for people with neurological conditions including Multiple Sclerosis, stroke, cerebral palsy, and spinal cord injury. The system combines hardware with an AI-powered app and personalized coaching to help users regain independence and confidence in daily activities.

3 investors

Circadia develops an FDA-cleared contactless patient monitoring platform using AI and hardware to enable early detection of patient health changes and reduce rehospitalizations. The platform serves healthcare providers and hospitals seeking to shift from reactive to predictive care delivery.

3 investors

City Therapeutics develops RNAi-based medicines targeting rare, specialty, and prevalent diseases using engineered trigger molecules and precision delivery ligands. The company aims to expand RNAi therapeutics beyond liver targeting to additional cell and tissue types.

3 investors

Clarametyx develops novel immune-enabling therapeutics targeting bacterial biofilms to modify disease progression in patients with chronic respiratory diseases.

3 investors

Clarapath develops SectionStar, an automated tissue sectioning system for histology laboratories that aims to improve slide quality, reduce turnaround time and lower costs. The company builds healthcare robotics for laboratory medicine and pathology workflows.

3 investors

Cleara Biotech is a biopharmaceutical R&D company developing peptide-based therapies that selectively eliminate cells with impaired p53 signaling, targeting cancer and chronic diseases. Its lead development candidates, CL04177 and CL04183, aim to induce apoptosis in cancer cells with mutant or impaired p53, with preclinical work in metastatic colon cancer and triple-negative breast cancer.

3 investors

3 investors

Clearcut Surgical develops a surgical device that combines electrosurgery, continuous smoke evacuation, and on-demand fluid suction in a single instrument. It is designed for surgical teams to improve efficiency, safety, and patient outcomes.

3 investors

ClearFlow develops PleuraFlow Active Clearance Technology, a device that maintains chest drain patency after cardiac surgery to reduce Retained Blood Syndrome complications, along with products for sternal fixation and reconstruction following sternotomy. The products are used in ICU and surgical settings for post-cardiac-surgery patient care.

3 investors

Clearside Biomedical is an intellectual property holding, investment, and commercialization company focused on its suprachoroidal space (SCS) ocular drug-delivery platform and microinjector technology. Following its emergence from Chapter 11 in 2026, it works to rehabilitate, use, and monetize its retained intellectual property.

3 investors

Clerio Vision is a development-stage medical device company developing LIRIC, a femtosecond laser technology that changes the refractive index of lens materials or corneal tissue without cutting or removing tissue. It applies this platform across four ophthalmic areas—multifocal contact lenses, myopia control lenses, post-implant intraocular lens adjustment, and incisionless laser vision correction—for patients with presbyopia, myopia, and other refractive errors.

3 investors

ClinChoice operates a network of investigator sites that participate in clinical studies to support drug and device development. The platform connects research sites with clinical trial opportunities and commercialization support.

3 investors

Cohealo operates a platform that lets health systems share medical equipment across their facilities, handling logistics, scheduling, and transportation to reallocate underused assets. It targets hospitals, ambulatory surgery centers, and medical office buildings looking to reduce equipment rentals and capital expenses.

3 investors

CoLabs Medical is developing The Ventor, an emergency airway and ventilation system intended to improve airway management and ventilation during cardiac arrest. The product is positioned as a complete solution for emergency medicine and is currently an investigational device under development.

3 investors

Collate builds AI-native software to automate documentation workflows across drug development and commercialization for life sciences companies. The platform uses machine learning to reduce manual paperwork so research and commercial teams can focus on advancing their core work.

3 investors

Conduit Health delivers essential medical supplies to patients through insurance-covered monthly deliveries, connecting them with licensed clinicians who handle the required prescriptions and paperwork. It works with Medicaid and Medicare plans and also offers organizations a way to provide their patients with access to medical supplies.

3 investors

CorFlow develops the Controlled Flow Infusion (CoFI) System, a catheter-based device for cardiologists to diagnose microvascular obstruction in heart attack (STEMI) patients and deliver therapeutic agents directly into the vasculature during PCI procedures. The medical device integrates into existing catheterization workflows to detect MVO and support cardiac treatment.

3 investors

Corsmed develops an MRI simulator that generates physics-based images replicating real scanner output as users adjust parameters such as sequence, hardware, anatomy, and pathology, aimed at MRI education and training for students, radiographers, and healthcare practitioners. It is also building SBR, an investigational post-processing medical device that produces synthetic contrast-weighted brain images from multi-sequence MRI acquisitions.

3 investors

Corveus Medical develops a minimally-invasive catheter-based treatment that deactivates a sympathetic nerve branch to address heart failure progression. The company targets physicians treating heart failure patients with limited therapeutic options.

3 investors

Covera Health applies AI to measure and improve care quality, providing quality insights used by healthcare providers and payers. The company focuses on defining, measuring, and delivering higher standards of care for patients.

3 investors

Cresilon develops plant-based flowable hemostatic gel technology that controls bleeding within seconds without manual pressure, with products for veterinary care (VETIGEL) and human trauma (TRAUMAGEL). Its customers include EMS agencies, trauma hospitals, military, law enforcement, and veterinary practices.

3 investors

Cryogenx develops the CGX1, a compact and portable body cooling device designed to rapidly lower core body temperature as an emergency treatment for heatstroke. The product targets scenarios where heat or humidity combines with strenuous physical activity, offering a portable alternative to full-body ice water immersion.

3 investors

RejuvenAir, developed by CSA Medical, is a bronchoscopic cryosurgical device that sprays metered doses of liquid nitrogen to destroy damaged airway cells and treat the underlying cause of COPD with Chronic Bronchitis. The investigational device is being evaluated in the SPRAY-CB clinical trial at hospitals across the United States for interventional pulmonary care.

3 investors

CurifyLabs develops an automated compounding system for pharmacies that uses robotics, GMP-manufactured excipient bases, and integrated quality control software to enable faster, safer preparation of customized medications. The platform serves hospital and retail pharmacies in Europe and the US, particularly for underserved patient populations including children and cancer patients.

3 investors