Medical Devices Startups

Sano Chemicals is a clinical-stage drug development company creating new chemical entities (NCEs) as first-in-class treatments for antimicrobial-resistant fungi and bacteria, with additional research into cancer applications. It develops novel drug products aimed at infectious diseases where existing treatments have become ineffective.

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Scalpel Ventures is a venture capital firm that invests in healthcare companies, with a focus on musculoskeletal care, cartilage regeneration, and sports medicine. It offers investors deal-by-deal opportunity selection with visibility into performance.

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Scienture Holdings operates and manages pharmaceutical companies that develop and commercialize specialty pharmaceutical products for underserved patient populations. The company focuses on addressing unmet medical needs through novel drug concepts, manufacturing expertise, and integrated sales and marketing capabilities.

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Seashore Surgical Institute is a multi-specialty surgical center providing care to children, adults, and seniors, operated as a joint venture between Virtua Health System, SCA Health, and local physician partners. The facility offers surgical and specialty care services with board-certified physicians and anesthesia providers.

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Secura Bio develops and commercializes oncology therapies for difficult-to-treat patient populations. The company leverages extensive experience in clinical development and market launch to bring life-prolonging cancer medicines to patients.

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Securisyn develops endotracheal securement devices, including its flagship SolidAIRity Flex device for adults and a planned pediatric version. The company's products are medical devices not yet available for sale, with a planned U.S. launch in 2026.

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Seigla Medical designs, develops, and manufactures medical devices for interventional physicians treating peripheral, cardiovascular, and neurovascular disease. The Minnesota-based company focuses on engineering and manufacturing products aimed at improving patient outcomes in vascular interventions.

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Sensoria Health builds a software-plus-hardware platform combining smart clothing and accessories with embedded sensors and agentic AI for remote patient monitoring and telerehabilitation. It serves the healthcare industry, providing clinicians and patients with real-time data to monitor recovery, detect issues early and support rehabilitation.

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Sensus Healthcare develops Superficial Radiotherapy (SRT) medical devices, including the SRT-100, SRT-100+ and SRT-100 Vision (which adds high-frequency ultrasound imaging), used to treat non-melanoma skin cancer and keloids without surgery. The devices are sold to physicians, institutions and healthcare systems for non-invasive, in-office outpatient treatment.

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Sentiré Medical Systems develops gas sensing technology for minimally invasive surgery that provides surgeons with additional intraoperative information. The SENSai platform integrates chemical sensing capabilities into operating room workflows to enhance surgical awareness and efficiency.

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Sepragen develops chromatography and bioreactor systems for large-scale pharmaceutical and biopharmaceutical manufacturing, including vaccine production, monoclonal antibodies, and viral vectors. The company serves pharmaceutical manufacturers and contract manufacturers requiring purification and bioprocessing equipment at production scale.

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Serenity Medical is a medical device company developing the River Stent, an investigational device for treating debilitating venous diseases such as Idiopathic Intracranial Hypertension (IIH) and Pulsatile Tinnitus, conditions that disproportionately affect women.

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Seriously Clean Ltd. is a contract manufacturer of Hypochlorous Acid (HOCl) products, including FDA-cleared 510(k) medical devices for wound management (prescription and over-the-counter), cosmetics, and an EPA-registered hospital-grade disinfectant with a C. difficile kill claim. It produces products for other companies across cosmetics, medical device distribution, eye care, animal, and skin care markets.

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Seurat Therapeutics is a biopharmaceutical company focused on discovering and developing novel neurotherapeutics, with research centered on immune signaling in brain health. Its work addresses conditions such as migraine and other neurological diseases.

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Siesta Medical develops AIRLIFT, a minimally invasive treatment for obstructive sleep apnea (OSA) that repositions the airway to reduce blockage as an alternative to CPAP masks and more invasive surgery. The company markets its treatment to sleep apnea patients and the physicians who treat them.

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SignPath Pharma develops small-molecule therapeutics to prevent cardiotoxicity caused by cancer treatments and other primary therapies. The company focuses on cardio-oncology, designing molecules to protect cardiac function in patients undergoing cancer therapy.

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Silver Creek develops growth factor-based therapeutics to promote cell survival and growth in response to injury. The company focuses on rescuing damaged cells through targeted biologic interventions.

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SiO2 Materials Science develops precision molded polymer containers with thin glass-like barrier coatings for pharmaceutical and biopharmaceutical applications. Its product line includes syringes, vials, and blood tubes designed for uses such as high-viscosity and high-pH formulations and cold storage.

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SiVEC Biotechnologies develops BactPac, a live biotherapeutic delivery platform that enables targeted delivery of nucleic acid therapies and gene editing therapies for clinical advancement. The company licenses its platform technology to pharmaceutical partners and pursues its own therapeutic pipeline in oncology and other disease areas.

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SkinJect develops a dissolvable microneedle patch delivery system to treat non-melanoma skin cancers such as basal cell carcinoma by stimulating an immune response against the disease. The device combines FDA-approved microneedles and chemotherapy cargo for topical skin cancer treatment.

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Skybound develops platform medical technologies targeting the physiological barriers to long-duration human spaceflight—such as bone loss, muscle atrophy, immune dysregulation, and radiation-induced damage—and applies the same technologies to major terrestrial health problems. Its focus areas include delaying and reversing age-related decline and chronic disease, delivering remote healthcare with minimal clinician supervision, and personalized real-time therapies.

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Buzz is a HIPAA-secure clinical communication and collaboration platform that consolidates messaging, document sharing, e-signatures, video, and EMR integration for distributed healthcare teams. It serves clinics, home health, hospice, and post-acute care providers seeking compliant care coordination workflows.

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SLAM BioTherapeutics is a preclinical-stage biotech developing first-in-class antibody-drug conjugates (ADCs) and bispecific monoclonal antibodies targeting the SLAM family of immune receptors (notably CD84/SLAMF5) for blood cancers such as MDS, AML, CTCL, and follicular lymphoma. Its lead asset SLM124 is planned to enter Phase 1 clinical trials in 2026, serving patients with hard-to-treat hematologic malignancies.

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SleepRes develops Kairos Positive Airway Pressure (KPAP), a pressure-delivery approach for treating sleep apnea, delivered through Kricket, an FDA-approved PAP device. The company serves sleep apnea patients and healthcare providers, aiming to improve therapy adherence compared to conventional CPAP.

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