Medical Devices Startups

Omeza is an ocean biotechnology company developing marine-based regenerative wound-care products, including its FDA-cleared OCM wound matrix made from cold-water fish peptides, omega fatty acids, and plant-derived lipids, to treat chronic, hard-to-heal wounds such as diabetic foot ulcers and venous leg ulcers in adults. The commercial-stage company serves the U.S. advanced wound care market and markets its products to clinical care sites.

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Ommo develops spatial tracking technology that provides 3D pose and position data in complex real-world environments, including safety-critical medical settings. Its proprioceptive tracking layer is designed to complement and correct perception systems by delivering ground-truth pose data through contact and interaction.

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OncBioMune is a clinical-stage biopharmaceutical company developing novel cancer immunotherapy products using proprietary vaccine technology designed to stimulate immune response against cancer cells. The company focuses on treatments for prostate cancer and other oncology indications, with its lead product in Phase 2 development.

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Onconetix is a commercial-stage biotechnology company that researches, develops, and commercializes proprietary therapeutics, diagnostics, and services in oncology. It serves clinicians and patients, with a product line that includes the Proclarix diagnostic.

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ONCOtracker is an incubator-stage biotech company developing approaches for monitoring and treating patients with multiple myeloma, other B-cell malignancies, and related disorders. It is part of a family of oncology-focused companies associated with the Berenson Cancer Center in the United States.

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OneOme is a precision medicine company that provides pharmacogenomics testing and analytics to healthcare providers, helping them optimize medication selection based on patients' genetic profiles. Co-founded by Mayo Clinic, the company serves healthcare teams and institutions globally seeking to improve patient outcomes and reduce costs through personalized medication decisions.

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OnKologic (Enable Life Sciences) develops Enable-NK cell culture media and a 10x concentrated supplement for expanding Natural Killer (NK) cells, used by NK cell research groups and in immuno-oncology cell therapy development. The products aim to improve NK cell performance metrics such as cytotoxicity, transduction efficiency, and cryopreservation for cancer research applications.

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Operating Room Innovations (ORI) develops surgical products designed by orthopedic surgeons and operating room scrub technicians to improve patient outcomes, surgical workflow efficiency, and operating room budgets. The company serves surgeons and other healthcare professionals in the operating room.

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An ambulatory surgical center specializing in ophthalmology procedures, serving patients and physician specialists in the Dallas area with clinical care and procedural services.

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OpticSurg is a healthcare software startup building mixed reality tools for surgical operations and frontline healthcare workers, with the goal of reducing complications and expanding provider capacity. It focuses on serving providers in vulnerable and underserved communities.

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Optimotion Implants designs and manufactures total knee replacement implants and surgical instrumentation, including the OI Blue Total Knee System aimed at younger, active patients. Its patent-pending instruments support a minimally invasive lateral approach that can be performed at outpatient ambulatory surgery centers.

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Optimvia engineers proteins to create new therapeutic products, focusing on designing enzymes and enzyme systems for biosynthetic manufacturing of critical medicines like heparin. The company uses its proprietary ADEPT Platform to computationally design novel proteins for pharmaceutical applications.

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Oragenics develops treatments for concussion and traumatic brain injury, focusing on clinical development of therapeutic candidates. The company combines neuroscience expertise with healthcare operational leadership to advance solutions for brain injury treatment.

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Orcosa is a clinical-stage life-sciences company developing the Rapid Infusion Technology (RITe) platform, orally disintegrating tablets designed to improve drug absorption through the cheek tissue without water. The company controls formulation, development, and manufacturing in-house and is advancing a proprietary cannabinoid composition for the management of pain and inflammation.

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Orgenesis provides decentralized manufacturing infrastructure for cell and gene therapies, enabling on-site processing of CGTs in regional centers through its POCare™ platform and OMPUL™ mobile processing units. The company aims to reduce costs, shorten development timelines, and improve patient access to personalized cell and gene therapies.

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Origami Surgical makes StitchKit, a product for robotic surgery that addresses exposed needle transfer to reduce lost sharps and near-miss sharps events. It targets surgical facilities and surgeons performing robotic procedures, aiming to improve patient safety and operating room efficiency.

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Origin Life Sciences is a clinical-stage biotechnology company developing IonoJet, a patented high-energy plasma device that generates and delivers a nitric oxide plasma stream to targeted areas of the body. Its therapy is being developed for chronic wound healing, skin and soft tissue infections, and other indications including dermatology, infection control, podiatry, and dentistry.

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Orthios Innovations makes The Weight Bear, an intraoperative device that holds a patient's foot in a simulated, loaded weight-bearing position hands-free for foot and ankle surgery and imaging. The radiolucent, foldable, sterilizable device is used in operating rooms, radiology departments, and orthopedic offices.

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Orthobond develops proprietary antimicrobial nanosurface technology that covalently binds to metallic and polymeric surfaces to mechanically kill bacteria, viruses, and fungi without antibiotics or eluting chemicals. Its first products, including Ostaguard, are antimicrobial surface treatments for implantable medical devices, with intended future applications in textiles, consumer goods, and high-touch public surfaces.

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OVN is a physician-led musculoskeletal provider network serving employers and patients through a national network of over 150 independent orthopedic groups and 5,000 providers. It delivers integrated MSK care including concierge support, physical therapy, and 24/7 urgent care access through both in-person and virtual services.

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OrthoPediatrics is a medical device company that develops products for pediatric orthopedic surgery, trauma, and deformity correction.

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ODI (OrthoDriven) develops AI-driven fluoroscopic imaging hardware and software for orthopedic surgeons, including its FreeCT technique that produces real-time 2D and 3D imaging of hard and soft tissue for surgical planning, intervention, and evaluation. Its product line includes surgical and clinical imaging units for musculoskeletal, extremity, and needle-guidance procedures.

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OssiFi develops small molecule therapeutics targeting bone growth modulation, specifically focusing on inhibiting Wnt pathway regulators to treat conditions like osteoporosis. The company leverages established drug development technologies and manufacturing expertise to advance candidates through clinical development.

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OsteoNovus develops medical device solutions for orthopedic surgery, leveraging its NovoGro technology platform for spinal and orthopedic applications. The company serves orthopedic surgeons and patients requiring surgical interventions.

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