Medical Devices Startups

Proton Intel develops medical devices for clinical use, drawing on biosensing and minimally invasive microdevice technology, with a focus on point-of-care diagnostics and continuous monitoring (CKM). The company works in the medtech and in-vitro diagnostics space.

4 investors

Proton Intelligence develops CKM™, a continuous monitoring medical device drawing on biosensing and minimally invasive microdevice technology for clinical use. The company operates in the medical device and diagnostics (IVD/point-of-care) space within health technology.

4 investors

Pulmonx develops the Zephyr Valve, a bronchoscopic device used to treat patients with severe COPD/emphysema without surgery. The company operates in the medical device industry, serving pulmonologists and patients with severe emphysema through a minimally invasive lung treatment.

4 investors

PuraCath Medical develops disinfection technology for catheter connections designed to reduce infection risk in healthcare settings. The company targets healthcare providers and patients who use catheters.

4 investors

Qritive develops AI-powered modules and a digital pathology workbench (Pantheon) that help pathologists identify, grade, and classify cancer, including prostate and colon cancer, lymph node metastasis, and biomarker analysis. Its hardware-agnostic tools integrate into existing digital pathology workflows and image management systems for laboratories and healthcare providers.

4 investors

Raidium develops an AI-native PACS viewer built on a foundation model for radiology, unifying image-viewing and diagnostic tasks in a single promptable platform. It serves radiologists and medical researchers, aiming to replace fragmented, task-specific AI tools with one workflow.

4 investors

RegCell Biosciences is a biotechnology company developing regenerative cell therapies, leveraging expertise in cell and gene therapy, manufacturing, and immunology to advance therapeutic treatments.

4 investors

Relievant offers the Intracept Procedure, a minimally invasive, FDA-cleared medical intervention designed to relieve chronic low back pain caused by vertebrogenic pain. The procedure targets patients with chronic low back pain seeking long-term pain relief and functional improvement.

4 investors

Remedy Robotics develops robotic systems for endovascular intervention, combining robotics, machine learning, and computer vision to help physicians perform precise neurovascular and cardiovascular procedures remotely or autonomously. It targets time-critical stroke and cardiovascular emergencies to expand access to specialized care regardless of patient location.

4 investors

RhyGaze develops gene therapies using optogenetic proteins to restore sight in patients with vision loss caused by retinal photoreceptor dysfunction. The company combines optogenetic technology with gene therapy delivery methods to enable light detection in degenerative eye conditions.

4 investors

Sangamo is a genomic medicine company using its proprietary zinc finger technology to develop gene therapies aimed at curing severe diseases, with a focus on neurology and rare disorders. Its pipeline covers indications such as small fiber neuropathy, prion disease, Fabry disease, and hemophilia A, including programs partnered with pharmaceutical companies.

4 investors

CSL is a biotechnology company that develops and manufactures plasma-derived and other therapies, including biotherapies for rare and serious diseases, vaccines, and treatments for iron deficiency and kidney disease. It operates through its CSL Behring, CSL Plasma, CSL Seqirus, and CSL Vifor businesses.

4 investors

Sava develops a wearable biosensor that continuously monitors multiple biomarkers (glucose, lactate, ketones, sodium, histamine, urea, alcohol, cortisol) in real-time, delivering health data to a mobile app for preventative health monitoring and chronic disease management.

4 investors

SeaStar Medical develops the Selective Cytopheretic Device (SCD), a therapy that targets highly activated neutrophils and monocytes to neutralize the hyperinflammatory immune response in critically ill ICU patients facing conditions such as infection, trauma, or surgery. The device integrates with existing hemodialysis delivery systems and is aimed at reducing dependency on dialysis and time in the ICU.

4 investors

Sequana Medical develops the alfapump system and DSR therapy for treating fluid overload in patients with conditions such as liver disease and heart failure. It is a publicly listed medical device company addressing unmet needs in the management of ascites and related conditions.

4 investors

4 investors

Singular Genomics develops spatial pathology technology to map molecules and cells directly in tissue for disease characterization. The company serves researchers and pathologists in biomedical research and diagnostics.

4 investors

SOLUtion Medical is a specialty pharmaceutical company developing reconstitution drug-delivery products, including its dual-chamber TwistJECT prefilled syringe and auto-injector for treating adrenal crisis. It aims to build a platform serving patients, caregivers, and clinicians, with a pipeline targeting additional indications such as mental health and fertility.

4 investors

SoundHealth develops FDA 510(k) cleared, drug-free medical devices that use acoustic resonance therapy via forehead bone conduction to treat nasal congestion and improve sleep. Its products include SONU, a non-steroidal alternative for nasal congestion, and Spatial Sleep, a wearable for sleep, personalized using AI for patients aged 12 and up.

4 investors

Sparrow Pharmaceuticals is a clinical-stage biopharmaceutical company developing targeted therapies for cardiometabolic disease. Its lead program, clofutriben, is an HSD-1 inhibitor being evaluated in a Phase 2b trial for patients with inadequately controlled type 2 diabetes driven by elevated cortisol.

4 investors

SPR is a medical device company that develops the SPRINT Peripheral Nerve Stimulation (PNS) System, a non-opioid, non-surgical, minimally invasive treatment for acute and chronic pain. Its technology targets the peripheral nervous system to treat pain in the back, extremities, head, and neck for patients in pain management.

4 investors

Surgicure Technologies develops medical devices for airway management in civilian and military settings. The company's products help healthcare professionals reduce adverse events and improve patient outcomes through optimized breathing support and faster deployment.

4 investors

Therab Medical is developing SnugLit, a wearable phototherapy device for treating neonatal jaundice in infants, delivering light therapy in a portable form for use in hospital and home settings. The company builds medical wearable technology aimed at infant care.

4 investors

Thymia provides a real-time voice biomarker platform that detects 30+ health and safety signals (including depression, fatigue, and burnout) from 15 seconds of speech, serving healthcare systems, automotive manufacturers, and first responder agencies across telehealth, AI agents, vehicles, and contact centers.

4 investors