Medical Devices Startups

Sparta Biomedical develops chemically engineered cartilage implants built on its Hyalos hydrogel platform, including Karthyx, an MTP hemiarthroplasty device that combines the cartilage-mimicking hydrogel with a titanium fixation technology. The company targets treatment of joint cartilage degeneration and osteoarthritis through cartilage-like implants for joints such as the great toe.

1 investor

Spartan Bioscience develops rapid, on-site DNA testing platforms designed for in-field diagnostic applications. The Canadian biotechnology company specializes in sample-to-result testing technology for infectious disease and molecular diagnostics.

1 investor

Specally develops AI software that enhances existing diagnostic tools like dermoscopes, reconstructing hyperspectral data from standard dermoscopy images to detect skin cancer and other skin conditions. It serves healthcare professionals and clinicians, supporting the workflow from early screening and triage to diagnosis and surgical margin definition.

1 investor

Specialty1 Partners is a business serving specialty dental practices, offering partnership and practice growth support through collaborative networking and operational services for specialist dentists.

1 investor

Specialty Smile Partners operates a network of pediatric dentistry and orthodontic practices across the Midwest, providing support, mentorship, and operational management to specialty dentists. The organization prioritizes doctor and team well-being alongside clinical quality and patient experience.

1 investor

Speckles manufactures adhesive eye patches designed for children undergoing occlusion therapy for amblyopia, developed by eye care professionals. The patches feature soft, hypoallergenic materials and are available in themed designs.

1 investor

SpectronRx develops and manufactures theranostic and diagnostic molecular isotope products (radiopharmaceuticals), operating research and production facilities including cyclotron sites. The company serves the nuclear medicine market and is headquartered in the central US, with facilities in Fishers and South Bend, Indiana.

1 investor

Spectrum Spine develops spinal and orthopedic medical devices, including its FDA-cleared BioBraille nanotechnology.

1 investor

A medical device company that translates scientific findings into life-saving medical products, operating under strict quality and compliance standards. The company develops and manufactures medical technologies in Germany.

1 investor

SpeeDx develops PCR-based diagnostic tests for sexually transmitted infections that detect pathogens and antibiotic resistance markers, enabling clinicians to make informed treatment decisions. The tests are designed for use with standard laboratory equipment in clinical settings.

1 investor

Spentys provides design automation and collaborative tools for orthopedic and manufacturing teams to streamline the design-to-production workflow for custom-made medical devices and orthoses. The platform integrates digital design with manufacturing processes, offering automated quality checks and compliance tracking for healthcare and medical device production.

1 investor

SphingoTec develops proprietary biomarkers for critical care diagnostics, addressing acute kidney injury, sepsis, and acute heart failure through partnerships with in vitro diagnostics companies and pharmaceutical firms. The company licenses its biomarker portfolio to global IVD partners to make clinical diagnostic products available worldwide.

1 investor

Spineart designs and manufactures spinal prosthetics and surgical instruments for orthopedic procedures, with a focus on cervical disc prostheses and fusion solutions for surgeons and hospitals. The company operates from Switzerland with an international presence.

1 investor

Spire Health provides continuous respiratory monitoring devices used by pulmonologists and patients to track lung disease. The company's sensors enable remote tracking of chronic respiratory conditions across the United States.

1 investor

SpliSense develops antisense oligonucleotides (ASOs) — small synthetic RNA-binding molecules — designed using proprietary algorithms for therapeutic applications including splicing modulation and gene silencing. The company focuses on inhaled ASOs delivered directly to the lungs for treating pulmonary and obstructive lung diseases with minimal systemic exposure.

1 investor

SPMED provides pharmacogenomics testing services and personalized drug therapy solutions, along with drug development and bioanalytical services for custom therapeutics.

1 investor

Spot Biosystems is a clinical-stage biopharmaceutical company developing non-viral gene therapies using extracellular vesicles as a delivery method. The company targets genetic diseases including muscular dystrophy and cardiac conditions.

1 investor

Spotlight Medical develops AI-enabled prognostic assays for cancer risk assessment, starting with myStage Dx, a test for early-stage ER+/HER2– breast cancer that helps clinicians identify low-risk patients within high-risk clinical groups. The assay analyzes routine pathology slides using machine learning to generate personalized relapse risk scores.

1 investor

Spring Loaded Technology develops bionic knee braces that enhance leg muscle power output for both therapeutic and athletic applications. The company serves people with mobility challenges seeking to restore function and reduce pain, as well as athletes looking to improve performance and reduce fatigue.

1 investor

SPR develops the SPRINT PNS System, a peripheral nerve stimulation device for pain relief. The company serves patients and healthcare professionals in the medtech/pain management space and is now part of Medtronic.

1 investor

A biotech company dedicated to developing new vaccines, combining scientific expertise with commercial and operational capabilities.

1 investor

SQK develops a deep-technology stack combining quantum, AI, and high-performance computing, entering the market through medical imaging workflows before expanding into energy, manufacturing, and research applications. It offers products for pilots, API access, validation services, and enterprise simulation, targeting healthcare, industrial, and scientific environments.

1 investor

Squegg makes a smart dynamometer device paired with a connected app to assess, monitor, and train grip and pinch strength for upper extremity conditions. It is aimed at patients and clinicians delivering in-person and remote care, using games and activities validated against the Jamar dynamometer.

1 investor

SRS Medical develops diagnostic and therapeutic technologies for urologic care, specifically for men with Benign Prostate Hyperplasia, using bladder function assessment to guide clinical treatment decisions.

1 investor