Medical Devices Startups

Abyrx (Orthocon) develops a materials science platform focused on therapeutic surgical devices, including water-soluble, resorbable hemostatic bone putty products such as MONTAGE. Its products are used by surgeons in orthopedic, trauma, spine, sports medicine, cranial, maxillofacial, and cardiothoracic procedures.

1 investor

Orthodontic Partners is an orthodontic service organization that partners with orthodontic practices, providing administrative and business support in areas such as accounting, HR, marketing, IT, and reporting, along with a clinical advisory board and shared best practices. It serves orthodontists across the United States who want operational support while retaining focus on patient care.

1 investor

Orthofix develops medical devices and surgical solutions for orthopedic procedures, with a focus on spine surgery and limb reconstruction. The company serves physicians and patients globally and emphasizes product quality, safety, and environmental responsibility in its operations.

1 investor

Orthoforge provides a diagnostic system using ultrasonic analysis and proprietary algorithms to quantify bone and soft tissue healing after injury, delivered through telemedicine without radiation exposure. The technology targets clinicians and orthopedic patients seeking objective, real-time monitoring of fracture recovery.

1 investor

Orthoforge develops ultrasound-based devices that quantify the stages of bone fracture and soft tissue healing without radiation exposure. Its Quantified Ultrasonic Healing analysis is aimed at healthcare professionals and supports remote patient monitoring via telemedicine across settings such as physician offices, hospitals, athletic training rooms, and homes.

1 investor

OrthoFX makes AirFlex clear dental aligners built with a patented HyperElastic polymer that delivers lower, sustained force for orthodontic treatment. The aligners are provided through partner doctors who perform 3D scans and guide patients through smile alignment and retention.

1 investor

OrthoLoneStar is a management services organization (MSO) that oversees and supports the operations of individual orthopedic practices. It is led by executive and divisional leadership teams.

1 investor

Orvida Pharma develops pharmaceuticals for rare genetic skin diseases and orphan indications, with expertise spanning drug development from early discovery through FDA and EMA regulatory approval.

1 investor

Orvue is developing a single-use, robotic camera for laparoscopy that is controlled directly by the surgeon, replacing manual scope handling with robotic positioning for greater stability. The platform is designed for surgical use and intended to capture procedural data.

1 investor

Osang Healthcare is an in-vitro diagnostic company that develops and manufactures biochemistry, immunology, and molecular diagnostic devices for global OEM and ODM partners. The company distributes diagnostic equipment to customers across more than 100 countries and plans to expand into digital health platforms and health supplements.

1 investor

Osheru is a medical device company that developed the Ziplyft, a sutureless device and technique for eyelid surgery aimed at surgeons and patients. Its approach targets faster recovery and improved outcomes in oculoplastic and ophthalmic procedures.

1 investor

Osivax develops vaccines targeting conserved internal viral structures to provide broader and longer-lasting protection against influenza, leveraging its proprietary oligoDOM technology platform. The company originated from research co-developed with the University of Oxford and is supported by public health foundations and pharmaceutical partners.

1 investor

Oska Health provides continuous care management for people with chronic kidney disease, aiming to reduce complications, hospitalizations, and healthcare costs through integrated digital and clinical support.

1 investor

A medical device CRO (Contract Research Organization) and innovation platform that provides incubation, development, and commercialization services for medical devices and healthcare technologies in China and internationally.

1 investor

OssDsign develops orthopedic and spine medical devices, drawing on expertise across clinical affairs, sales, and manufacturing from leading companies like Medtronic and Boston Scientific. The company serves surgical and orthobiologic markets with a team of executives experienced in bone healing and medical device commercialization.

1 investor

Domestic provider of speech and language therapy services for children with developmental and learning disorders, offering assessment, intervention, and early screening through a combination of localized international methodologies and expert supervision.

1 investor

Osteal Therapeutics is a clinical-stage pharmaceutical company developing novel treatments for orthopedic infections, particularly periprosthetic joint infections. Its lead product, NEXCHANGE KIT, is a drug-device combination designed for localized antibiotic delivery to infected joint prostheses.

1 investor

Osteocentric develops orthopedic implant systems for bone fixation, including fasteners, plates, and surgical instruments that use UnifiMI mechanical integration technology. The company serves orthopedic surgeons and hospitals treating fractures and skeletal injuries.

1 investor

Osteon Medical designs and manufactures titanium dental implant hardware, including single, bridge, and full-arch implant componentry, for dental labs and clinicians. The company operates milling and production facilities and develops digital implant solutions such as its Nexus system and intraoral scanning technology.

1 investor

Oticara is a clinical-stage biopharmaceutical company developing an investigational intranasal corticosteroid therapy for chronic rhinosinusitis (CRS). Its product is a single-dose, semisolid emulsion formulation placed by an ENT physician under endoscopic guidance, targeting patients with persistent symptoms after topical therapies and sinus surgery.

1 investor

OTOFARMA is an Italian manufacturer of custom hearing aids with ISO certification, sold exclusively through partnered pharmacies. The company also offers telemedicine audiology services, positioning itself as Italy's only certified hearing aid constructor with integrated remote consultations available in over 3,000 affiliated pharmacies.

1 investor

Otolith Labs develops a non-invasive, headworn wearable using patented Vestibular Resonance Therapy (nVRT) to treat vestibular conditions such as vestibular migraine and chronic vertigo. The device is a non-pharmacological medical product tested in clinical studies for patients suffering from balance and vertigo disorders.

1 investor

Otos is a platform that combines hearing and cognitive health assessment into a single system, with automated testing, triage, and continuous patient monitoring for integration into clinical workflows. It serves health systems, ENT and audiology practices, primary care, neurology, and longevity clinics, and is running clinical validation and pilot programs in Europe and the U.S.

1 investor

OTS Medical develops an FDA-cleared anchoring system for arthroscopic soft-tissue-to-bone reattachment in orthopaedic surgery, including the RAPHAEL 25 anchor that can be used with or without bone marrow. Its technology targets minimally invasive soft tissue repair for orthopaedic surgeons and patients in the United States and Europe.

1 investor