Medical Devices Startups

CardioSignal is a CE-marked Class IIb software-as-a-medical-device app that uses smartphone gyroscope and accelerometer sensors (gyrocardiography) to detect signs of atrial fibrillation in a one-minute measurement. It serves consumers for self-monitoring as well as care providers for population health programs and point-of-care clinical diagnostics, and is available across the UK, Norway, Switzerland and several EU countries.

4 investors

Caretaker Medical builds VitalStream ART, a multi-modal device for continuous beat-to-beat hemodynamic monitoring that supports both invasive arterial-line and non-invasive wearable methods on a single platform. It is used by hospital clinicians across pre-op, OR, ICU, and step-down settings to detect patient deterioration earlier and reduce complications.

4 investors

Cellanome develops a live-cell analysis platform using CellCage technology to create controlled microenvironments that enable researchers to observe cell behavior and molecular changes over time. The platform generates structured multimodal data for life sciences researchers and biopharma companies focused on oncology, neuroscience, immunology, and aging research.

4 investors

CellChorus develops a visual AI platform called TIMING that performs high-throughput dynamic analysis of single cells, measuring cell activation, killing, and movement over time for biopharmaceutical research. The company serves biopharmaceutical companies and therapy developers seeking to understand cellular function and phenotype.

4 investors

CellFE develops a microfluidic-based gene editing technology and a benchtop device for research and process development of cell therapies. Its products serve cell therapy researchers and developers, aiming to enable non-viral genome editing that maintains cell viability and scales from discovery to commercial manufacturing.

4 investors

Ceribell is a medical technology company that develops products for detecting and monitoring seizures, including EEG-based diagnostic systems. It serves healthcare providers in the neurodiagnostics and medical device field.

4 investors

Charco Neurotech develops the CUE1, a non-invasive device that uses vibratory stimulation to ease movement symptoms and improve quality of life for people with Parkinson's disease. The company builds its technology together with and for Parkinson's patients based on ongoing scientific research.

4 investors

Cipher Surgical makes OpClear, a laparoscopic scope lens cleaning device consisting of a control unit and a sheath that attaches to the scope, delivering automated CO2 flow to reduce fog and on-demand saline lens wash for continuous intra-abdominal vision. It is designed for laparoscopic surgeons across specialties such as general, bariatric, gynecology, urology, and colorectal surgery, and is compatible with most major laparoscopic instrument brands.

4 investors

Citryll is a biotech company developing CIT-013, a first-in-class monoclonal antibody that targets Extracellular Traps (ETs) to treat immune-mediated inflammatory diseases, with a focus on rheumatoid arthritis and hidradenitis suppurativa. The company runs clinical trials for its ET-targeting therapy aimed at resolving inflammation.

4 investors

Cleerly develops FDA-cleared, AI-driven analysis of noninvasive coronary CT (CCTA) imaging to characterize and quantify coronary artery disease. Its technology, validated in peer-reviewed clinical trials, is used by healthcare organizations to support personalized treatment decisions in heart care.

4 investors

CRIO develops eSource software for clinical research sites to manage electronic source documentation and trial workflows. The platform serves research sites, sponsors, and CROs in the clinical trials industry.

4 investors

Coherus Oncology develops and commercializes immuno-oncology therapies, including the approved LOQTORZI, to treat patients with cancer. The company focuses on expanding its pipeline of clinical-stage candidates targeting the tumor microenvironment.

4 investors

Comind is developing non-invasive neurotechnology that measures a range of neurophysiological brain signals in a single bedside measurement. The technology is aimed at doctors and clinical care settings to support patient assessment and treatment.

4 investors

Compression Works manufactures the AAJT-S, an FDA-cleared external abdominal tourniquet device for hemorrhage control used by emergency medical services, hospitals, and military personnel.

4 investors

Contego Medical develops the Neuroguard IEP System, a 3-in-1 carotid stenting device combining a carotid stent, dilation balloon, and integrated embolic protection with a 40-micron filter to reduce stroke and cognitive impairment from microembolization. The company also produces peripheral vascular devices; Medtronic is now the sole U.S. distributor of the carotid product.

4 investors

contextflow develops AI-powered diagnostic tools for radiologists, including computer-aided detection software for chest CT scans to identify lung cancer, interstitial lung disease, and COPD. The platform provides automated nodule detection, quantification, and tracking capabilities to support clinical reporting.

4 investors

Crystalys Therapeutics is a clinical-stage biopharmaceutical company developing targeted therapies for gout, a chronic metabolic disease caused by elevated uric acid. Its lead investigational therapy is a selective URAT1 inhibitor designed to lower serum uric acid by targeting renal urate reabsorption pathways.

4 investors

Curocell is a Korean biotech company developing CAR-T cell therapies for cancers such as lymphoma and leukemia, as well as autoimmune conditions like lupus. Its lead therapy anbalcel (marketed as Limkato) received manufacturing/marketing approval, making it one of Korea's most advanced CAR-T-focused companies.

4 investors

CurvaFix develops the CurvaFix Low Profile intramedullary nailing system, curved implants for surgical stabilization of pelvic fractures. The devices are used by orthopedic trauma surgeons and orthopedic oncologists and are FDA-cleared for use in the United States.

4 investors

CVRx develops Barostim, an implantable medical device that uses baroreceptor activation to treat heart failure patients and improve their functional capacity and quality of life.

4 investors

Damona develops precision neuromedicines aimed at treating cognitive deficits associated with neurodegenerative and psychiatric disorders such as Alzheimer's disease, depression, and schizophrenia. Its lead drug targets a specific subunit of the GABA-A receptor to improve neuronal function and reverse cognitive impairment.

4 investors

Dannce provides AI-powered motor assessment software that analyzes smartphone video of patient movement to extract clinical-grade motor data for neurologists, enabling remote monitoring of progressive neurological diseases like Parkinson's. The platform allows patients to perform guided movement exams at home and delivers objective biomarkers to clinicians for continuous symptom tracking between appointments.

4 investors

Deep Blue Medical develops surgical devices for soft tissue surgery and hernia repair, including its T-Line Hernia Mesh product line and the T-Line TCS (Tissue Control Suture) for optimal tissue tension, reinforcement, and defect closure. Its products, used in US surgical suites and in development, target the hernia device market and other soft tissue procedures to reduce repair failure and recurrence.

4 investors

Denali Therapeutics develops therapeutics for neurodegenerative diseases. The company focuses on discovering and developing novel drug candidates targeting specific neurological conditions.

4 investors