Medical Devices Startups

Endoron Medical develops transcatheter anchoring and sealing devices for aortic procedures, including Aortodock (a nitinol docking system to stabilize transcatheter valves in low-calcium aortic regurgitation and stenosis anatomies) and Aortoseal (a multi-stapling fixation and sealing system for endovascular aneurysm repair grafts). Its products serve physicians treating patients across the aortic continuum from TAVR to EVAR.

1 investor

EndoSound makes the EndoSound Vision System (EVS), a technology that converts standard upper GI endoscopes into a functioning endoscopic ultrasound (EUS) scope at lower cost than traditional systems. It targets ambulatory surgery centers and other facilities that cannot afford or justify conventional EUS equipment.

1 investor

EndoStim develops a neurostimulation medical device system for treating drug-resistant gastroesophageal reflux disease (GERD) by restoring esophageal function while preserving normal anatomy.

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EndoStream Medical develops the Nautilus intrasaccular device, a self-conforming scaffold used with coils to treat wide-necked brain aneurysms by maximizing neck coverage and promoting progressive occlusion. The company builds neurovascular medical devices for physicians treating intracranial aneurysms.

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Endovascular Engineering develops clot removal technologies targeting venous thromboembolism. The company serves the medical device and healthcare sectors.

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Endovision develops AI software that assists doctors during endoscopic procedures, aiming to improve diagnostic accuracy, consistency, and completeness of examinations. It serves gastroenterologists and hospitals with computer-vision-based diagnostic support tools.

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Ensem Therapeutics is a drug discovery and development company focused on oncology therapeutics, leveraging proprietary computational chemistry and protein structural dynamics platforms. The company advances small molecule and targeted therapies from discovery through clinical development.

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Ensmile is an OEM manufacturer of invisible orthodontic aligners, offering end-to-end services from digital treatment planning to personalized packaging using AI-powered systems. It serves aligner brands, dental professionals, and dental material distributors, with manufacturing and offices in Portugal, Germany, and Central Asia.

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Entegrion develops a point-of-care viscoelastic coagulation monitoring system (VCM) for rapid hemostasis assessment in clinical settings including trauma, surgery, and obstetrics. The company serves clinicians in civilian and military medicine, with regulatory clearance in Europe.

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Enteral Access Technologies develops medical devices for safe placement of nasogastric feeding and decompression tubes in clinical settings. The company manufactures DoubleCHEK™, a combined CO2 and pH indicator device that reduces misplacement risk and unnecessary radiation exposure.

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Entia develops at-home blood monitoring solutions for healthcare providers and patients. The company aims to reduce treatment burden and healthcare system disruption by integrating monitoring technology into daily life.

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ENTvantage Dx develops rapid, in-office diagnostic tests for primary care physicians and otolaryngologists to identify the causes of ear, nose, and throat illnesses. The company operates in the in-vitro diagnostics sector serving the medical diagnostics industry.

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Enumera Molecular develops technology and a platform for simplified, lower-cost workflows that enable liquid biopsy and high-dimensional omics assays for laboratories. It targets clinical labs performing molecular diagnostics.

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Countable Labs (formerly Enumerix) develops a digital PCR platform that performs genetic analysis with higher sensitivity, precision, and dynamic range than legacy PCR methods. The technology serves oncology, NIPT (non-invasive prenatal testing), infectious disease, and cell and gene therapy applications.

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Enuvio manufactures microfluidic devices for cell co-culture and compartmentalization research, including neuronal co-culture, axon guidance, and chemotaxis platforms for life sciences researchers.

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EnVision Endoscopy develops medical devices for gastrointestinal endoscopic surgery, including an Image Guided Suturing System for tissue approximation and management of gastrointestinal defects. The company aims to improve patient outcomes and reduce healthcare costs for endoscopy procedures.

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Enzene Biosciences is a biologics company focused on the development and manufacturing of biopharmaceuticals. It is a subsidiary of Alkem Laboratories and offers advanced manufacturing processes as a strategic partner for biologic products.

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Enzyme develops a Quality Management System (QMS) software platform for life science companies including drug, biologic, device, and digital product manufacturers, designed to streamline regulatory workflows and generate FDA-ready documentation.

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Enzyre develops a handheld diagnostic device that performs multiple blood coagulation assays in parallel to identify bleeding causes at the point of care. The device aims to enable rapid therapy adjustment for patients and reduce healthcare costs by bringing laboratory testing capabilities to clinical settings.

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Eon Health provides a platform for detecting and managing lung cancer early, helping healthcare systems identify and track pulmonary nodules to improve patient outcomes. The solution serves hospitals and healthcare networks seeking to improve early cancer detection through systematic care management.

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Eos BioInnovation invests in early-stage regenerative medicine therapies and technologies, focusing on cell, gene, and tissue therapies that target disease causes. The firm partners with researchers and entrepreneurs to accelerate the translation of breakthrough science into commercial biotech companies.

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Epic CRISPR develops GEMS (Gene Expression Modulation System), a modular epigenetic editing platform that combines DNA-binding proteins, guide RNAs, and modulator proteins to create genetic medicines. The company serves the biotech/medtech sector with advanced tools for precise gene expression control and disease treatment.

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Epidutech develops an AI-powered surgical navigation platform for spine surgery that uses a patented "magnetic camera" attached to the patient's body to track a permanent magnet embedded in surgical tools in real time. It targets hospitals, clinics, and Ambulatory Surgery Centers (ASCs), replacing bulky hardware-based navigation with a compact, brand-agnostic software approach.

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EpiEndo Pharmaceuticals is a clinical-stage biopharmaceutical company developing therapies for chronic respiratory diseases such as COPD, based on research into macrolides and their effects on the lung epithelium. Its lead program, EP395 (glasmacinal), is a non-antibacterial macrolide with anti-inflammatory activity that is Phase 2b ready.

1 investor