Longevity Startups
430 companies tagged Longevity, with their investors and founders.
NeuroInitiative is a computational biology company that uses a patented AI simulation platform to model neural molecular interactions and prioritize drug targets across aging biology and neurodegeneration. Its platform produced Vincere Biosciences' VB-23, a USP30 inhibitor Parkinson's disease therapy entering Phase 1 clinical trials in 2026.
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New Frontier Bio is a biotechnology company with a cross-functional management team experienced in start-ups, science, strategy, and M&A across healthcare, biotechnology, and cosmetics.
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Oisín Biotechnologies develops non-viral genetic therapies built on its Fusogenix Proteo-Lipid Vehicle (PLV) delivery platform, which delivers DNA and RNA payloads to tissues throughout the body and allows repeat dosing. Its pipeline targets the biology of aging, with programs in targeted fat removal, muscle building, and longevity biology across aesthetic and longevity medicine.
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Ora Biomedical develops molecules aimed at increasing human resilience using insights from longevity medicine, targeting applications such as cancer care, skin repair, and trauma recovery. Its WormBot-AI platform combines robotics, computer vision, and deep learning to run automated high-throughput drug screening in live C. elegans models.
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Oragenics is a biotech company developing ONP-002, an intranasal neurosteroid drug delivered via a proprietary nasal device to treat the underlying brain injury in concussion patients. The therapy is in clinical development, with Phase 1 complete and Phase 2 trials underway, aiming to address inflammation, oxidative stress, and swelling from brain trauma.
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Personalized Stem Cells (PSC) isolates, expands, and cryopreserves a person's own mesenchymal stem cells from fat tissue in an FDA-compliant lab for future physician-directed use. It offers consumer stem cell banking and personalized regenerative medicine memberships (StemReady, StemPreserve, StemInsure) and supports Right-to-Try access pathways in the U.S.</parameter> <parameter name="hq_city">San Diego
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PreventiveMD is a telehealth service offering compounded and FDA-approved GLP-1s, peptides, and other targeted therapies for weight loss, recovery, and healthy aging, along with advanced lab testing and genetic risk screening. Patients complete an online assessment, have a U.S.-licensed provider review and prescribe, and receive ongoing physician-adjusted care through a portal for a flat monthly price without insurance.
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Prolifagen is developing PRO302, a therapy designed to induce cardiomyocyte proliferation to regenerate damaged heart muscle tissue and restore cardiac function. The company focuses on treatments for heart disease and heart attack recovery.
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ProtoKinetix develops AAGP, a molecule aimed at protecting and preserving cells for use in health therapies. The company positions the molecule as a potential component in treating various medical conditions.
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Retain Health builds software that guides individuals to adopt brain-healthy habits through personalized, evidence-based recommendations aimed at reducing the risk of Alzheimer's disease. Its non-invasive tools focus on behavior change and prevention education, designed to scale across broad populations.
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Revalesio is a clinical-stage pharmaceutical company developing therapies that target mitochondrial function to address the bioenergetic and metabolic failures underlying stroke, neurodegenerative diseases, and aging. It focuses on protecting mitochondrial structure and restoring cellular homeostasis for patients with neurological conditions lacking effective treatment options.
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Revel Pharmaceuticals develops enzyme-based therapeutics designed to recognize and reverse molecular damage that accumulates in the body's structural tissue — collagen, elastin, and extracellular matrix — targeting age-related damage that drives disease. The company screens natural enzyme variants against real substrates to identify and engineer them into treatments.
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Rezilir Health is a precision medicine clinic offering brain health, longevity, and complex chronic condition care, including therapies such as hyperbaric oxygen, IV infusions, ketamine, neurofeedback, and genetic testing. It serves patients with neurodegenerative disease, autoimmune disorders, dementia, and environmental illnesses from its Hollywood, Florida location.
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S1P Therapeutics is a preclinical-stage biotechnology company developing drugs that target novel nodes in the S1P pathway for treating kidney and autoimmune diseases. Its aim is to create medicines with less toxicity than existing S1P pathway drugs.
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Sano Chemicals is a clinical-stage drug development company creating new chemical entities (NCEs) as first-in-class treatments for antimicrobial-resistant fungi and bacteria, with additional research into cancer applications. It develops novel drug products aimed at infectious diseases where existing treatments have become ineffective.
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Sen-Jam is a computational drug discovery and development company developing a class of anti-inflammatory therapeutics based on combinations of already-approved small molecules (NSAIDs and antihistamines). Its pipeline targets conditions including alcohol hangover, viral and coronavirus infections, vaccine side effects, arthritis, and opioid dependence, tolerance, and withdrawal.
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Seniorly operates an online directory of senior living communities and connects families with local advisors and virtual tools to find assisted living, memory care, and independent living options. It provides free advisory services, cost calculators, care quizzes, and guides for families in the United States.
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Skybound develops platform medical technologies targeting the physiological barriers to long-duration human spaceflight—such as bone loss, muscle atrophy, immune dysregulation, and radiation-induced damage—and applies the same technologies to major terrestrial health problems. Its focus areas include delaying and reversing age-related decline and chronic disease, delivering remote healthcare with minimal clinician supervision, and personalized real-time therapies.
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Sperity Health offers a physician-led preventive health program for employers and individuals, combining advanced diagnostics (labs, screenings, wearables), clinical interpretation, personalized plans, and year-round engagement through a web app. It integrates third-party diagnostics and monitoring devices into one coordinated program tracking metrics like biological age, VO2 max, and a proprietary health score.
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Tinos Tx develops first-in-class small molecule inhibitors targeting the RNA demethylase FTO to destabilize tumor-driving RNA and kill cancer cells. The company builds on research into how RNA methylation controls cellular survival to create cancer therapeutics.
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Upgrade Labs offers in-person recovery and performance facilities where clients receive non-invasive cell health scans, biomarker testing, and personalized protocols guided by "biohacker" technicians. It serves individuals seeking to improve physical recovery, fitness, and overall wellness through technology-based assessments and optimization plans.
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Vitro Biopharma is a biotechnology company developing Wharton's jelly-derived (umbilical cord) mesenchymal stem cell therapies for autoimmune diseases and inflammatory disorders. It manufactures its cell therapy product candidates under cGMP conditions with ISO 9001:2015 and ISO 13485:2016 certification for the immunology and inflammation market.
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