Healthtech Startups

S4 Medical develops the esolution device, a technology intended to protect the esophagus from ablation energy during cardiac ablation procedures. The company operates in the medical device sector focused on cardiac electrophysiology.

4 investors

SafeBeat uses engineering and machine learning to develop solutions for cardiac care and arrhythmia management. The company serves cardiologists, electrophysiologists, and healthcare organizations.

4 investors

Sage builds AI-powered tools that improve patient access to healthcare by matching patients with appropriate providers, reducing administrative tasks, and optimizing care navigation. The platform serves healthcare systems and their operations and patient access teams.

4 investors

Sagimet is a clinical-stage biopharmaceutical company developing therapies targeting fatty acid synthase (FASN) for metabolic diseases and oncology. The company advances drug candidates through clinical trials in areas such as metabolic disease.

4 investors

Salve is a Fertility Experience Platform that provides fertility clinics with unified patient communication, automated workflows, patient education, and secure data handling in a single app. The platform integrates with leading EMRs and uses AI-powered support to improve clinic efficiency and patient retention.

4 investors

SanaHeal develops soft-material and bioadhesive technologies, such as hemostatic and tissue-regeneration solutions, for medical device applications. The company focuses on translating biomaterials research into commercial products to address challenges in human health.

4 investors

Sangamo Therapeutics develops gene-editing therapeutics using zinc finger and modular integrase platforms to treat genetic diseases including hemophilia, Fabry disease, and neuropathy. The company is currently undergoing Chapter 11 reorganization and conducting clinical trials for various therapeutic applications.

4 investors

Santa Ana Bio is a biotech company developing engineered antibody therapeutics that target the immune pathways and cells driving autoimmune and inflammatory diseases. It is building a pipeline of first-in-class and best-in-class biologics for conditions such as inflammatory bowel disease and scleroderma-associated interstitial lung disease.

4 investors

Sapyen offers at-home male fertility testing kits that measure sperm parameters including count, concentration, motility, and morphology, with results reviewed by certified labs using WHO 2021 methodology. The company serves individuals seeking to understand their reproductive health for conception planning or post-vasectomy confirmation.

4 investors

Satellite Bio develops an off-the-shelf cell therapy that delivers functional liver cells (hepatocytes) into the body, where they engraft to restore liver function. The therapy targets patients with severe liver diseases and hepatic insufficiency who lack effective treatment options.

4 investors

Scanvio Medical develops AI-assisted software that provides clinicians with real-time guidance during transvaginal ultrasound examinations to support earlier assessment of suspected endometriosis. An ETH Zurich spin-off focused on women's health, its products fall in the medical device / AI ultrasound category.

4 investors

Scanwell Health develops smartphone applications that enable patients to perform diagnostic tests at home, starting with an FDA-cleared app for urinary tract infection testing and treatment. The platform targets people seeking faster diagnosis and treatment of acute and chronic conditions without visiting a clinic.

4 investors

Scripta offers AI-powered prescription navigation solutions that help members, employers, and health plans identify clinically appropriate and affordable medication alternatives. The platform integrates with existing benefits ecosystems to reduce pharmacy spend and improve outcomes for employers, health plans, consultants, and third-party administrators.

4 investors

SeaStar Medical develops the Selective Cytopheretic Device (SCD), a therapy that targets highly activated neutrophils and monocytes to neutralize the hyperinflammatory immune response in critically ill ICU patients facing conditions such as infection, trauma, or surgery. The device integrates with existing hemodialysis delivery systems and is aimed at reducing dependency on dialysis and time in the ICU.

4 investors

See-Mode develops software that applies AI and computational fluid dynamics to CT and MRI scans in order to estimate a patient's stroke risk. It is built to run within existing hospital imaging workflows, so clinicians can obtain these assessments from scans already acquired rather than ordering new imaging.

4 investors

Semble operates a clinical platform for outpatient and private healthcare providers, helping them coordinate care and manage the patient journey through a unified care-orchestration system with AI capabilities. It serves healthcare groups and clinics across the UK and France.

4 investors

Serna builds a platform to unlock the transcriptome as a drug target for drug discovery. The company integrates technology and biology to change drug discovery processes.

4 investors

Sesame is a telehealth marketplace that connects patients with board-certified providers for cash-pay medical visits without insurance, with prices shown upfront and visits starting at $34. It offers online consultations across a range of care needs through independently owned provider practices using its platform.

4 investors

Shattuck Labs is a biotechnology company developing biologic medicines targeting TNF receptors, including the TL1A/DR3 axis, for patients with cancer and inflammatory or life-altering diseases. It is built around proprietary protein-engineering platforms and a pipeline of immunotherapy drug candidates.

4 investors

The She Matters Alliance collects insights from pregnant and postpartum mothers to improve maternal health outcomes through partnerships with hospitals and healthcare organizations. The organization focuses on advancing equitable, compassionate maternal care across the perinatal period.

4 investors

Shimmer provides coaching, community, and digital tools designed specifically for people with ADHD, combining expert guidance with peer support to help them reach their potential. The platform serves neurodivergent individuals seeking ADHD-specific support outside traditional mental health systems.

4 investors

Sift Biosciences develops T-cell immunotherapies for cancer and autoimmune diseases, using an AI-driven discovery platform combined with metagenomics and high-throughput cellular screening to identify microbially derived molecules that activate memory T cells. Its SIFT platform supports pipelines in oncology and autoimmunity, with the latter partnered with a large pharmaceutical company.

4 investors

Signatur Biosciences develops molecular diagnostic solutions using qPCR technology for in vitro diagnostics, targeting clinical and laboratory markets. The company aims to deliver advanced diagnostics on widely available instrumentation to expand access to cutting-edge healthcare globally.

4 investors

SilverCloud by Amwell is a digital mental healthcare platform designed to provide mental health services to a broad audience. The company is committed to accessibility standards for disabled users.

4 investors