Enterprise Software Startups

OpenClinica eConsent is a digital consent platform for clinical trials that enables participants to review and electronically sign informed consent forms using media-rich content on any device. It serves academic researchers, sponsors, contract research organizations (CROs), and clinical trial sites who need to streamline enrollment while maintaining regulatory compliance across decentralized, hybrid, and in-person studies.

1 investor

OnePatch offers an AI-based site reliability engineering tool that instruments production services, monitors their behavior, detects incidents, and works to resolve them through to a shipped fix. It is aimed at engineering and operations teams responsible for on-call and service reliability.

1 investor

OpenDrawing uses AI models trained on electrical and P&ID diagrams to convert drawings (from PDFs, images, or scans) into structured bills of material and data that feed into ERP, quoting tools, digital twins, and asset management systems. It serves electrical manufacturers, switchgear builders, OEMs, and contractors, offering custom part matching and enterprise deployment options.

1 investor

OpenExchange (OE) provides a platform and managed services for virtual and hybrid events, including investor relations communications, earnings calls, town halls, and corporate meetings. It serves IR teams, institutional banks, and investment managers, handling video and audio streaming with dedicated event management support.

1 investor

OpenExO is a community platform with 40,000+ members offering certification programs, training, and coaching in exponential transformation for organizations and professionals. The platform provides tools and resources to help consultants, coaches, and organizational leaders implement exponential business models and strategies across industries.

1 investor

OpenGDP is an operating layer that unifies settlement, tokenized assets, and governance for real-world economic execution across enterprises, institutions, and governments. It provides APIs and infrastructure for programmable money, asset issuance, and coordinated economic workflows with institutional-grade controls and auditability.

1 investor

OpenGrowth Ventures (OGV) is a venture creation platform and studio that helps founders turn ideas into companies by combining AI research, structured venture theses, expert validation, and operational support such as legal, finance, talent, and go-to-market infrastructure. It spins off and operates a portfolio of AI-agent-focused ventures across sectors including risk/compliance, market intelligence, talent, and investing.

1 investor

OpenHack is an AI security engineer that scans code, runs autonomous pentests, verifies vulnerabilities with working proof-of-concept exploits, and prioritizes findings by business impact, generating fix pull requests. It serves engineering teams at startups and enterprises, covering application code, authentication flows, APIs, dependencies, and secrets.

1 investor

Openi Analytics turns public, proprietary, and commercially available data into strategic intelligence using lawful OSINT, analytics, and AI-assisted workflows reviewed by human analysts. It serves governments, enterprises, and select institutional clients seeking to understand and reduce digital risk and exposure.

1 investor

OpenInt provides a platform for teams to build product integrations quickly using no-code or low-code tools, offering unified APIs for data operations or direct database synchronization.

1 investor

OpenIntake provides AI-powered intake automation for law firms that captures and converts phone inquiries into client matters around the clock.

1 investor

OpenLake is a real-time inference platform that lets companies deploy open models with one click and continuously improve model quality using their own datasets, reinforcement learning environments, and conversations. It is aimed at organizations that want to run and update AI models without maintaining an in-house AI research lab.

1 investor

OpenMarkets provides a platform that streamlines the purchase and sale of medical equipment for healthcare providers and suppliers through connected workflows and direct supplier access. The company serves healthcare organizations seeking to improve efficiency and reduce costs in equipment procurement and disposition.

1 investor

OpenMethods provides integration and workflow automation software for contact centers, enabling seamless connections between CRM systems, communication tools, and third-party applications without requiring custom development. The platform helps customer service teams access real-time data, automate manual tasks, and improve operational efficiency while maintaining enterprise-grade security.

1 investor

OpenProse is a declarative language and framework for orchestrating multi-agent AI workflows, allowing developers to write contracts in Markdown that compile into executable topologies for coordinating AI agents running on Claude, Codex, or other language models.

1 investor

Sigma develops an AI-based operating system for mergers and acquisitions, providing software to support M&A processes for the professionals and firms involved in dealmaking.

1 investor

Opensense is a platform that enables marketing, sales, and IT teams to manage company-wide email signatures, launch email ad campaigns, extract sales insights, and meet compliance requirements from a single interface. The company serves enterprise organizations seeking to maintain brand consistency and control across corporate email communications.

1 investor

OpenSight uses large language models to automatically handle customer support tickets, enabling growing companies to manage inquiry volume and resolve customer questions without proportional increases in support staff.

1 investor

OpenSilo offers a B2B SaaS platform for breaking down data silos and enabling secure knowledge and data exchange across enterprise organizations. It targets large enterprises, with content addressing data governance, AI agent governance, and compliance topics.

1 investor

100 Open Startups operates a ranking and awards program that tracks open innovation between startups and large corporations in Brazil and Latin America. It also runs events, mentorship immersion programs, and rankings that connect startups, corporations, and business professionals.

1 investor

OpenSteer builds specialized AI agents that perform autonomous work by browsing the web, integrating with user tools, and executing on schedules either in the cloud or on-premises. The platform serves developers and enterprises looking to automate business processes and workflows.

1 investor

OpenWrench provides software for retail and restaurant chains to manage facility repairs and maintenance, aiming to reduce costs and save time for operators. It serves retailers and restaurant chains of varying sizes.

1 investor

Opera is an agentic security operations platform designed for cyber-physical environments, providing security capabilities for physical and digital security integration.

1 investor

OpEra runs an automated operations research lab that combines mathematical optimization and AI to improve operational efficiency and decision-making across sectors such as retail, logistics, manufacturing, and agriculture. It serves operations and supply chain leaders, including VPs of operations, plant managers, and COOs.

1 investor