Deep Tech Startups

Tidal Metals uses patented technology to extract magnesium from seawater or desalination brine using electricity, aiming to establish domestic U.S. primary magnesium production. Its magnesium targets defense, aerospace, automotive, and advanced manufacturing supply chains that depend on the metal.

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Growth Curve Bio operates an R&D-grade precision fermentation facility specializing in microbial fermentation for synthetic biology programs, serving biotech and life sciences companies developing novel products. The company provides integrated services from strain optimization through pilot-scale manufacturing, combining contract research with GMP-informed documentation and process validation to de-risk commercialization.

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Hansen Engine is an independent research company that develops a variable-displacement supercharger technology for OEM automotive engines aimed at a global market. Based near Minneapolis, it operates an engine test laboratory and works on advancing automotive engine technologies.

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Haptech Defense Systems manufactures electronic weapon simulators and drop-in recoil kits for military training, compatible with VR, AR, MR, and live simulation environments. The company's ERIS platform provides simulated recoil and instrumentation without requiring pneumatic infrastructure.

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HavaH Therapeutics develops T+Ai, a subcutaneous extended-release pellet combining testosterone and anastrozole, aimed at preventing and treating hormone receptor positive breast cancer, including ductal carcinoma in situ (DCIS) and ER+ disease. The clinical-stage company targets the intra-mammary hormonal balance to slow tumor growth and reduce the need for surgery.

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Heligenics is a genomics and cell biology company that develops assays and platforms for drug screening and genetic analysis. The company serves pharmaceutical and biotech organizations conducting research in functional genomics and cellular engineering.

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Hepanova is a clinical-stage biotech developing first-in-class oral small-molecule therapeutics for chronic liver diseases and inflammatory conditions, including MASH, liver fibrosis, and IBD. Its lead candidate, HPN-01, is an oral dual IKKα/IKKβ inhibitor that has completed a U.S. Phase 1 trial.

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HexaTech develops and commercializes aluminum nitride (AlN) semiconductor material, using a proprietary crystal growth process to produce single-crystalline AlN boules and substrates with far fewer defects than competing technologies. Its substrates support the fabrication of high-Al-content AlGaN and other III-nitride semiconductor devices.

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HFR Networks provides optical, packet, and radio access network transport solutions, including Smart Tunable Optics, flexiHaul transport, and FTTX/Carrier Ethernet equipment, for service providers, enterprises, and utility companies. It serves Tier 1 mobile operators, regional fiber builders, and enterprises across Korea, Japan, and North America, supporting 4G/5G and Private 5G deployments.

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Hidenn.ai offers an engineering simulation platform that combines LLM-guided conversational workflows, automated finite element analysis (FEA) pre-processing and solving, and data-driven and physics-based surrogate modeling. It is aimed at engineers performing computational mechanics and CAE simulations of physical systems.

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Highland Instruments develops ESStim, a noninvasive brain stimulation technology intended to treat chronic pain, neurodegenerative diseases, and psychiatric disorders, currently limited to investigational use under US law. The company also holds intellectual property in artificial intelligence, imaging, neuromodulation, wearable sensors, and human movement kinematics.

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Hone develops autonomous AI systems designed to own outcomes rather than execute individual tasks, letting operators specify a desired result and constraints while the system builds, orchestrates, and improves agents to achieve it. It works with AI companies and large enterprises to apply these autonomous systems to complex processes.

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Hunterian Medicine develops a CRISPR delivery technology using adeno-associated viruses to enable in vivo gene editing for treating genetic diseases. The company targets rare genetic disorders including cystic fibrosis, muscular dystrophy, and ALS, where existing treatments remain unavailable for the vast majority of cases.

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HYPRLABS is a technology company presenting a product called HYPR ACTV. The available page content offers little detail about the company's specific offering or target market.

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IIoT-OXYS uses sensors and machine learning to detect patterns and anomalies in industrial data, providing actionable insights for pharmaceutical, manufacturing, agricultural, defense, and structural health monitoring clients. The company helps organizations achieve Industry 4.0 standards through AI-analyzed sensor data and custom algorithms.

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IKIN develops technology products spanning holographic displays, augmented reality, 5G, and IoT. The company positions itself around emerging consumer and immersive technology.

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ImmuneSensor Therapeutics is a clinical-stage biotechnology company developing orally available small molecule cGAS inhibitors that target the cGAS-STING innate immune pathway to treat inflammatory and autoimmune diseases. Founded on research from UT Southwestern Medical Center, it advances a pipeline of drug candidates for immune-related conditions.

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Imunon develops DNA-based immunology technologies designed to treat difficult-to-treat conditions including ovarian cancer and infectious diseases. The company's platforms instruct the immune system to generate targeted therapeutic responses.

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Imvax is a clinical-stage biopharmaceutical company developing personalized immunotherapies aimed at treating solid tumors, including glioblastoma. Its platform draws on autologous, cell-based approaches to target cancer.

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Indiana Integrated Circuits (IIC) develops and licenses Quilt Packaging, a patented chip-interconnect technology that connects separate dies along their edges to build system-in-package assemblies for RF, microwave, digital, power, biomedical, and optical electronics. It also offers custom micro- and nano-fabrication, prototyping, and testing services to electronics researchers and manufacturers.

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Inertial Labs develops inertial sensors, navigation systems, and positioning technology for applications requiring continuous operation when GNSS signals are unreliable. The company manufactures integrated platforms combining inertial measurement units, multi-sensor fusion, and AI algorithms for aviation, maritime, defense, and industrial sectors.

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InspireSemi designs high-performance, energy-efficient accelerated computing chips for AI, HPC, and graph analytics workloads across industries including defense, financial services, and drug discovery. The company is based in Austin, Texas and uses a fabless model with outsourced manufacturing partners.

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Inspirit IoT develops Xcelo, a chip-agnostic, general-purpose high-level synthesis (HLS) tool for designing FPGA hardware, including machine-learning IPs and IP integration. The tool targets hardware designers, offering higher design productivity than traditional RTL workflows through LLVM IR and polyhedral model-based optimizations.

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Integrated Deposition Solutions (IDS) designs and manufactures the NanoJet line of aerosol printers for manufacturing settings, R&D laboratories, and universities. The company builds print modules and stand-alone print platforms sold and shipped worldwide, with all manufacturing done in the United States.

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