Deep Tech Startups

Spectral develops SCALE, a compiler toolkit that recompiles CUDA code to run on a range of GPUs from different vendors, including AMD and NVIDIA, without rewriting the codebase. It targets developers building GPU-accelerated applications who want vendor flexibility and higher performance.

1 investor

Spectro Inlets builds a microchip inlet system for mass spectrometers and turnkey analytical instruments such as the EC-MS, used by research institutions for electrochemistry and battery studies. Spun out of the Technical University of Denmark, the company also runs pilot projects applying its measurement technology to biogas and wastewater process monitoring.

1 investor

Spectroplast manufactures production-grade silicone parts using proprietary photocurable silicone resins (TrueSil) and additive manufacturing for medical devices, robotics, and precision manufacturing. The company serves OEMs across Europe and the Americas, eliminating traditional manufacturing constraints of tooling costs, lead times, and minimum order quantities.

1 investor

Speqqle combines scientific modeling with AI to analyze material composition and properties across industries using optical spectroscopy data. The company serves large corporations, spectrometer manufacturers, and research scientists.

1 investor

Speratum Biopharma develops RNA interference (RNAi) therapeutics for cancer and other hard-to-treat genetic diseases, using its proprietary NoPass RNAi design platform and Nano-In nanoparticle delivery system. Its lead candidate, NM-198, is based on the tumor-suppressor microRNA miR-198 and targets multiple oncogenic pathways in solid tumors.

1 investor

Spexi operates a distributed network of drone pilots (branded LayerDrone) that captures standardized, ultra-high-resolution aerial imagery and turns it into geospatial datasets such as orthomosaics, 3D point clouds, and Gaussian splats delivered via API. Its data serves teams building and training spatial AI, digital twins, and physical AI systems, with applications in mapping, infrastructure inspection, construction progress tracking, and change detection.

1 investor

Sphere Photonics develops ultrafast pulsed laser solutions, including femtosecond lasers and related optical systems for scientific and industrial applications. The company serves customers requiring high-performance laser technology for research and applied photonics work.

1 investor

Spherea provides test and simulation solutions to clients across multiple industries worldwide.

1 investor

Spherie provides reality capture services including 360° and linear film production, 3D scanning, drone inspection, and AR/VR development to digitize physical spaces into spatial data and immersive media. It serves tourism, industry, and media production clients, and has developed patented drone systems that capture unobstructed 360° footage.

1 investor

Spherik is an accelerator established in Romania that supports early-stage startups and facilitates connections between entrepreneurs, investors, corporations, and universities across Europe. The organization operates as a public-private partnership focused on developing the startup ecosystem at the European level.

1 investor

SPhotonix develops 5D optical data storage that encodes data inside fused silica glass for high-capacity, long-term archival and active storage. It targets data centers and the AI data lifecycle, positioning its technology as a storage tier between fast drives and deep archive tape.

1 investor

Spice Labs provides software scanning and cryptographic analysis tools that generate artifact dependency graphs of software systems and assist organizations in managing their transition to post-quantum cryptography. The platform serves development teams and enterprises seeking to understand software dependencies and remediate security vulnerabilities.

1 investor

Spike Dynamics develops microrobotic actuator systems designed to operate in extreme environments such as radiation-heavy, vacuum, high-pressure, and temperature-extreme settings. Its ultra-compact, modular platform targets applications across medtech, aerospace, defense, and robotics.

1 investor

Spineart designs and manufactures spinal prosthetics and surgical instruments for orthopedic procedures, with a focus on cervical disc prostheses and fusion solutions for surgeons and hospitals. The company operates from Switzerland with an international presence.

1 investor

Spiral Hydrogen develops a centrifugal, bubble-free alkaline electrolyzer designed to produce green hydrogen at higher efficiency and lower capital cost than conventional systems. Its technology targets the industrial hydrogen market — including oil refining, fertilizers, plastics, and steel — aiming to reach cost parity with fossil-based hydrogen.

1 investor

Spiral develops autonomous indoor drones (flying robots) designed to operate in non-GPS environments for tasks such as inspection of structures and warehouse inventory. It targets on-site field technicians and companies considering indoor drone adoption, offering drone-based solutions built around real-world operational needs.

1 investor

Spiral develops visual inspection technology using LiDAR and computer vision for quality control and maintenance in industrial sectors, including wind energy and aircraft repair.

1 investor

Spirrow Therapeutics develops a first-in-kind polymer lung surfactant (PLS) based on nanotechnology to treat acute respiratory distress syndrome (ARDS), with a focus on restoring lung function in infants. The therapy is designed to reduce alveolar surface tension and fluid accumulation in the lungs.

1 investor

SpliSense develops antisense oligonucleotides (ASOs) — small synthetic RNA-binding molecules — designed using proprietary algorithms for therapeutic applications including splicing modulation and gene silencing. The company focuses on inhaled ASOs delivered directly to the lungs for treating pulmonary and obstructive lung diseases with minimal systemic exposure.

1 investor

Sports Vision builds a sports-specific large language model that analyzes athletic video to produce qualitative and quantitative performance analytics. It serves athletes, coaches, scouts, teams, and sports organizations with tools for video feedback analysis, movement quality scoring, and injury-prevention monitoring.

1 investor

Spring Silicon builds full-stack compute infrastructure — from compilers to ASICs — designed specifically for physical AI and edge inference in robots, drones, autonomous vehicles, and heavy industry. It targets sectors such as manufacturing, defense, energy, and transportation.

1 investor

SpringWit is a neurotechnology company focused on brain health and awareness.

1 investor

Squarehead Technology designs and manufactures electronically steerable microphone arrays that turn sound into actionable data for acoustic situational awareness. Its systems serve the industrial and security/defense sectors, with applications including passive sound-based drone detection and acoustic monitoring of machinery for early failure detection.

1 investor

SRC develops radar, sensing, and information technology for defense and national security applications, including border surveillance systems and airborne processing hardware. Its offerings serve military and government customers addressing threats across multiple domains.

1 investor