Deep Tech Startups

Hamamatsu Photonics makes the L10711-26 open-type microfocus X-ray source, offering a minimum resolution of 0.2 μm, selectable W or LaB₆ cathodes, a 20–160 kV tube voltage range, and four focus modes. The product targets non-destructive testing (NDT) and industrial CT imaging workflows.

1 investor

Optics11 Life develops optical fiber-sensing instruments and software platforms that measure mechanical properties of cells, tissues, and biomaterials to accelerate medical research and drug development. The company partners with life science researchers and laboratories to enable non-destructive characterization of biological samples for applications in drug discovery, tissue engineering, and disease modeling.

1 investor

OptimalPSI develops patient-specific spinal fusion implants (TLIF) designed with an optimization algorithm that accounts for each patient's bone structure and load distribution to reduce subsidence risk. An ETH Zürich spin-off, it serves spine surgeons treating lumbar fusion patients at risk of post-operative subsidence.

1 investor

Optiple develops optical products and lens technologies, including eyewear, bike visors, and AR optics. The company holds patents related to curved lens bonding technology (GHLC).

1 investor

OptiSeis Solutions provides seismic exploration and subsurface imaging services with an emphasis on high-resolution data processing and advanced reservoir characterization. The company serves oil and gas exploration clients seeking cost-effective, environmentally mindful geophysical solutions.

1 investor

Optixlog provides a self-hosted, AI-native context layer that captures raw engineering data generated across simulation, layout, fabrication, metrology, and characterization workflows. It is aimed at enterprise engineering teams that need to retain control over their infrastructure, access, and data handling.

1 investor

Metamaterials develops advanced materials and functional surfaces using nanofabrication technologies such as lithography, holography, and metamaterial coatings. Its products serve markets including brand protection, banknote and government ID security, aerospace and defense, automotive, consumer electronics, energy, and medical imaging.

1 investor

A space data center company. The page provides a founder bio but no concrete details about the product or offering.

1 investor

OQC designs and manufactures quantum computers engineered for commercial applications, beginning with systems optimized for financial services and security sectors. The company develops Application Optimised Compute systems through a multi-generation product roadmap targeting quantum advantage in finance, defence, life sciences, and cryptography.

1 investor

Ora Graphene develops nano-materials based on graphene technology for high-performance audio applications. The company serves audio equipment manufacturers and beyond through commercialized graphene solutions.

1 investor

ORamaVR develops a platform for high-fidelity medical simulation training using extended reality technology, serving device companies, simulation centers, and hospitals globally. The company addresses the challenge of scaling medical education through spatial computing and computer graphics innovations.

1 investor

Orange Photonics makes portable LightLab 3 analyzers that let users test the potency of cannabis and psychedelic mushrooms in-house or in the field within minutes, without sending samples to a lab. Its instruments serve cannabis and psychedelics operators needing on-site cannabinoid and psilocybin potency measurement.

1 investor

OraVentis develops a real-time decision-support system using an industrial-grade LiDAR to detect and control fugitive dust and particulate atmospheric emissions in industrial operations. The solution maps dust concentrations across hundreds of meters and generates contextual alerts to guide operators in addressing emission sources at their origin.

1 investor

Orb builds resilient communications technology that combines broadband, cellular, and satellite networks into a single self-healing connection with automatic failover for mission-critical and crisis operations. It targets defense and critical-infrastructure users operating where existing network infrastructure is unavailable or unreliable.

1 investor

Orbis Medicines is a drug discovery company developing orally bioavailable macrocycle drug candidates as alternatives to injectable biologics, targeting both intracellular and extracellular protein targets. It uses a proprietary chemistry and machine-learning platform to systematically explore macrocycle chemical space and generate optimized drug candidates.

1 investor

OrbitAID develops on-orbit servicing technology for satellites and spacecraft, including in-space refuelling, autonomous docking, repair, and inspection to extend asset life and enable orbital maneuverability. Its systems include a standardized docking and refueling port and pose-estimation software, demonstrated through microgravity missions.

1 investor

Orbital Micro Systems (now Weather Stream) develops and manufactures miniaturized millimeter-wave microwave radiometer instruments for ground, air, and space-based applications, including its GEMS family used for satellite meteorology and weather forecasting. It also supplies custom radiometer calibration hardware to partners such as Ball Aerospace and NASA JPL for defense and Earth-observation missions.

1 investor

Orca provides an online, memory-controlled deep-learning platform that replaces periodic batch retraining with continuous "steering," letting teams edit data in specialized memoryset databases to update, customize, and audit AI model behavior at inference time. It targets AI/ML teams building predictive and generative systems for use cases such as LLM/agentic evaluation, classification and recommendation, threat detection, and anomaly detection.

1 investor

Ore Energy develops long-duration iron-air battery technology for renewable energy storage using cost-effective, recyclable materials like iron, water, and air. The company targets the global sustainable energy transition market with energy storage solutions.

1 investor

Organ Recovery Systems develops organ preservation products and services, including machine perfusion technology for donor kidneys, for transplant programs and transplant professionals. The company supports over 400 transplant programs across 49 countries and also provides clinical and technical support services.

1 investor

Organo-ID develops iPSC-derived organoid systems, including 3D hepatocyte models, to test drugs in better-modeled biological systems for predictive diagnostics and personalized therapies. The company serves drug development and treatment applications in oncology and rare disease, operating from Turkey with a global focus.

1 investor

ORIA is a Paris-based company, spun off from ENS Paris in 2022, that uses a proprietary mechanical microfluidic platform to extract intact, high-purity functional organelles at industrial scale. Its organelle products serve pharmaceutical companies, biotech firms, and academic institutions for drug discovery, disease modeling, and therapeutic research.

1 investor

Origami Therapeutics is a preclinical-stage biopharmaceutical company developing protein degrader therapeutics to treat neurodegenerative diseases, starting with Huntington's disease. The company uses a proprietary platform that harnesses the body's natural protein disposal system to degrade disease-causing proteins.

1 investor

The company develops industrial additive manufacturing technology, offering 3D printers, materials, and software for applications from functional prototyping and tooling to small-batch and production parts. It serves manufacturers across industries such as automotive with technologies including FDM, PolyJet, P3, SAF, and SLA.

1 investor