Deep Tech Startups

XM Therapeutics develops extracellular matrix-based therapies to treat patients with chronic disorders, with initial applications targeting heart failure and pulmonary fibrosis. The company is based in Providence, Rhode Island and leverages partnerships with Brown University for research and development.

1 investor

Xore develops Boxray on-stream analyzers for automated online analysis of ore slurry in mineral concentrator plants, helping mining operations monitor material composition and control their processes. The company also provides service, maintenance, staff training, and financing options such as leasing and payment plans.

1 investor

A biotechnology company developing a peptide-based delivery platform that uses lipid raft targeting to transport therapeutic proteins into the cytosol of human cells with minimal lysosomal degradation. The technology is designed for pharmaceutical companies and researchers needing intracellular delivery of therapeutic macromolecules.

1 investor

XREAL designs and manufactures consumer AR glasses and spatial computing platforms, leveraging proprietary optical engines and on-device AI integration. The company serves consumers and developers globally with a retail presence across 40+ countries, holding the #1 market share in AR glasses sales revenue from 2022–2025.

1 investor

Xronos provides an open-source, component-based development framework for Python and C++ that runs on Linux, aimed at engineers building robotics and automation systems. It offers a deterministic runtime plus built-in telemetry, tracing, and automatic architecture visualization to make testing and deployment more reliable.

1 investor

Xsensio develops wearable biosensor systems that continuously monitor physiological parameters to detect health risks in real-time. The company aims to commercialize Lab-on-Skin technology for healthcare applications.

1 investor

Xtalic uses a computational material design platform to develop nanostructured metal alloys with enhanced durability, corrosion resistance, and temperature stability for manufacturers with demanding product requirements. Its alloys are used in applications such as electronic connectors, smartphone and EV charging, wearables, and wireless charging, with design and sampling done in a nanomaterial lab in Marlborough, Massachusetts.

1 investor

Crystal Sonic develops acoustic-based technology for splitting and reusing semiconductor wafers, reducing manufacturing waste and costs for chipmakers producing advanced semiconductors for electrification, communications, and photonics applications.

1 investor

Xterna develops xeno nucleic acid (XNA) technology to engineer cell-specific binders aimed at treating diseases currently considered untreatable. The company operates in the biotechnology and therapeutics space.

1 investor

Xtrac Medical develops a sheathless, vibration-based technology for extracting implanted cardiac leads with improved safety and procedural efficiency. The company serves electrophysiologists and medical institutions performing lead extraction procedures.

1 investor

XtreeE develops large-scale 3D concrete printing systems for the construction industry. The company focuses on helping clients design, specify, and deploy printing technology toward more sustainable building practices.

1 investor

XtreeE is a construction technology company specializing in large-scale 3D concrete printing systems, serving the construction industry. The company develops and deploys solutions to support environmental transition in construction.

1 investor

XtremeX develops a technology platform for mineral exploration that delivers deeper, more precise core samples for battery and precious metals mining while reducing carbon footprint and environmental impact.

1 investor

X-trodes develops technology for collecting and analyzing electrophysiological data outside traditional medical facilities, enabling research, diagnosis, and treatment applications. The company serves researchers, clinicians, and healthcare institutions seeking portable electrophysiological monitoring solutions.

1 investor

XVP Photonics develops high-reliability photonic products and systems for aerospace, military, telecom, and industrial applications. The company specializes in optical fiber, laser systems, and integrated optics solutions with expertise in design, qualification, and manufacturing.

1 investor

Xyall operates in medical technology and molecular diagnostics, leveraging expertise in digital pathology and health innovation to scale diagnostic solutions.

1 investor

Xylo develops mechanism-based drug therapies targeting psychiatric and neurological disorders using computational and rational drug design approaches. The company serves patients and healthcare systems seeking novel treatments for complex neuropsychiatric conditions.

1 investor

XYMA Analytics is a deep-tech company spun out of IIT Madras that uses patented ultrasonic waveguide technology combined with AI to deliver multi-point temperature and multi-parameter measurements for industrial processes. It serves multinational manufacturers globally with IIoT-enabled process monitoring and AI-based predictive maintenance.

1 investor

Yama is developing an electrified, electrochemical carbon capture platform using advanced membranes and a proprietary non-toxic sorbent to capture CO₂ from dilute, low-concentration gas-fired streams. It targets applications such as net-zero data centers and AI infrastructure, aiming to lower capture costs relative to conventional methods.

1 investor

YBVR provides a streaming platform that lets audiences watch live events through multiple synchronized feeds, including immersive 360/180 video and traditional 2D, with interactive viewer control. Its patented delivery technology aims to maintain visual quality at low bandwidth across devices.

1 investor

The Yellow SiC Company produces high-purity (<1ppm impurities) yellow cubic silicon carbide (3C-SiC) at industrial scale using a patented process. The material is used in applications such as power semiconductors.

1 investor

YellowDog provides computational infrastructure and job orchestration for deep tech and enterprise computing workloads. The company serves organizations requiring distributed compute resources and workflow management.

1 investor

YEO provides a continuous facial recognition SDK that verifies user identity throughout an active session using on-device biometric processing and multi-layer liveness detection. The solution targets regulated industries including financial services, legal, insurance, government, and cybersecurity firms seeking to prevent fraud and session takeover.

1 investor

YISSUM is a technology transfer organization founded in 1964 that commercializes research from the Hebrew University, connecting groundbreaking academic innovations with industry partners and global markets. It operates an ecosystem supporting researchers, entrepreneurs, and industry collaborators in licensing, partnerships, and venture creation.

1 investor