Deep Tech Startups

HaptX develops wearable haptic gloves and related technology that enable realistic touch simulation in virtual reality, spatial computing, and robotics applications. The company creates hardware and software for human-machine interaction using microfluidic technology.

1 investor

Hardhat is a development environment for Ethereum smart contracts, providing tools for testing, deployment, debugging, code coverage, and verification, with a runtime rewritten in Rust for performance. It serves Solidity developers ranging from individual builders to engineering organizations, supporting tests in both Solidity and TypeScript along with an extensible plugin ecosystem.

1 investor

This page is a podcast interview/article about Empirical Ventures, not a company website. Empirical Ventures is a UK-based deeptech investment fund that backs early-stage entrepreneurial scientists at pre-seed and seed stages.

1 investor

Hardolass is a materials technology company that develops functional nanomaterial coatings and thin films through collaborative research with multiple universities. The company originated as a painting contractor and evolved into a specialized liquid chemical manufacturer focused on advanced coating solutions.

1 investor

Hardware Intelligence builds an agent-native toolchain for chip design, starting with Wave, an agentic waveform debugger for terminal use.

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Genesis Molecular uses deep learning and molecular simulation to accelerate drug discovery and development. The platform helps identify and optimize drug candidates for challenging diseases.

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Harvard Bioscience manufactures and supplies life science research tools and laboratory equipment for academic institutions and pharmaceutical companies. The company serves the research and development market with advanced instrumentation and solutions.

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Hashlist provides tooling and integration services for OEMs and technology partners building physical AI systems, bridging the gap between chip performance and AI model deployment in vehicles, robots, and autonomous systems. The company operates a platform connecting customers with a network of experts to handle full-stack system integration from silicon constraints to production deployment.

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HAXTRON is a Polish company developing PROBE, an aerial robotic platform built around a turbine engine mono-unit designed to operate in extreme conditions and withstand physical contact with surrounding objects. The platform can be fitted with sensors for industrial inspections (including ATEX-rated areas) and used in marine or fire search-and-rescue missions.

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HB11 Energy develops laser-based boron fusion technology to generate baseload electrical power without radioactive waste or dependence on intermittent renewables. The company commercializes fusion-related laser systems and components targeting the energy sector.

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HBOX Therapies is a medical device company developing the MiRA system, an extracorporeal gas exchange device that oxygenates blood and removes carbon dioxide independently of the lungs as a less invasive alternative to mechanical ventilation. It targets patients with acute respiratory failure in intensive care units, using proprietary technologies including an artificial lung, a hyperbaric gas management system, and a novel blood pump.

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Heat Inverse develops cooling technology aimed at reducing emissions, drawing on expertise in mid-infrared photonics and metamaterials. The company operates in the climate and cleantech space with a focus on passive or advanced cooling systems.

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Helical offers an AI platform for drug discovery that tunes bio foundation models to a customer's own biology and lab data, orchestrating them into ranked, mechanistically grounded candidate shortlists for target identification and biomarker discovery. It is built for biopharma R&D teams and provides model-agnostic harnesses, benchmarking, and enterprise deployment with data controls.

1 investor

Helix Earth makes a bolt-on retrofit system for commercial building HVAC that separates humidity removal from cooling using a patented liquid-desiccant filter (Helix MICRA) derived from NASA spacecraft life-support technology, reducing energy use and equipment strain. The company also applies its liquid-gas mass transfer technology to carbon capture, rare earth extraction, industrial filtration, and atmospheric water generation.

1 investor

Hellen Systems develops eLORAN, a terrestrial positioning, navigation, and timing (PNT) technology that serves as an independent complement to GPS/GNSS for critical infrastructure, government, and commercial customers. The company integrates low-frequency transmission, timing equipment, antenna design, and cybersecurity to provide resilience against satellite service disruptions.

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Hello Robot develops mobile manipulator robots designed to assist and enhance life for people of all ages, including children, older adults, and people with disabilities. The company provides a platform for innovators to build new applications and technologies in robotics.

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HelloWorld Robotics develops autonomous delivery robots for last-mile logistics in both outdoor and indoor environments, with its flagship robot TARS already deployed in Japan. The Malaysian company also manufactures autonomous driving golf carts for controlled environments.

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A deeptech AI company focused on advancing cytometry technology and hematology analysis applications.

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HemostOD engineers and manufactures universal (HLA-low) platelets using a proprietary platform that immortalizes hematopoietic progenitor cells and generates platelets via microfluidic bioreactors. The preclinical biotech targets applications in thrombocytopenia, tissue-targeted cargo delivery, regenerative medicine, and therapeutic stem cell culture.

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hemotune develops a magnetic nanoparticle platform for targeted magnetic separation in medical and biomanufacturing applications. The platform removes disease triggers and harmful agents from the bloodstream or processes biological materials with high selectivity and scalability.

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HEPT Lab is a fabless semiconductor company that designs chips based on technology developed over a decade at Caltech.

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Hera reviews mechanical engineering drawings (prints) automatically, checking parts against current drawings and catching missed callouts in minutes rather than the days senior engineers spend reading prints by hand. It targets manufacturing and industrial teams, keeping the review process auditable and on-premises.

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Hera BioLabs provides gene editing technologies and cell line development services for drug discovery researchers. The company offers custom cell line platforms, animal models, and bioprocessing solutions using transposase technology and proprietary tools like the SRG Rat platform and CleanCut GS CHO system.

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Heran Partners is a venture capital firm investing in healthcare and life sciences companies that use enabling technologies—hardware, software, or services—to address unmet clinical needs and improve patient outcomes. The firm focuses on companies at seed through Series B stages that combine financial returns with societal impact by advancing treatments, generating actionable patient insights, or improving drug development efficiency.

1 investor