Deep Tech Startups

Anara is an AI platform designed for scientific research that searches document libraries and the web, summarizes findings with automatic citations, and helps researchers write with verified sources. It specializes in document analysis and synthesis for scientific and life science workflows.

8 investors

Ångström AI develops AI-powered physics simulations for pharmaceutical drug discovery, computing molecular properties like solubility, lipophilicity, and crystal structure stability to replace traditional lab experiments. The platform uses machine learning interatomic potentials and free energy calculations to accelerate and derisk solid form development for pharma companies.

8 investors

Apollo is a venture capital firm that invests in life-science and biotechnology startups, combining entrepreneurial expertise with deep scientific knowledge to support early-stage companies in drug development and personalized medicine.

8 investors

Applied Compute builds proprietary AI agents trained on enterprise-specific workflows and data that continuously improve through real-world usage. The platform helps Fortune 500 companies unlock institutional context and deploy autonomous agents within their own secure environments.

8 investors

AquaEye develops portable sonar technology for water rescue operations, enabling first responders like firefighters, lifeguards, and police to locate and rescue people in aquatic emergencies. The company designs intuitive, easy-to-use sonar devices to help rescue teams act faster and safer during critical water incidents.

8 investors

Aralez Bio produces noncanonical amino acids using biocatalysis, including compounds that add rigidity to peptide backbones and increase enzyme resistance. The company manufactures these at multi-kilogram scale for peptide and pharmaceutical applications.

8 investors

Arrakis Therapeutics develops RNA-targeted small-molecule (rSM) medicines, working independently and with partners to create drug candidates aimed at the root causes of disease. Its pipeline includes a candidate for Type 1 Myotonic Dystrophy (DM1), a form of muscular dystrophy.

8 investors

ARRIS is an advanced manufacturing technology company that uses its Additive Molding process to align continuous fibers, electronics, and metallic components into topology-optimized composite parts. It partners with companies in consumer goods, portable electronics, industrial, and transportation to produce lighter and stronger products at scale.

8 investors

Aspen Neuroscience develops iPSC-derived autologous cell therapies for neurological diseases, with a lead product (ANPD001) in Phase 1/2a clinical trials for Parkinson's disease. The company is a clinical-stage biotechnology firm focused on personalized neuron replacement therapies.

8 investors

Astrus develops AI software for analog microchip design, automating the hand-crafted layout of analog circuits used in high-speed interconnects and other critical chip components. The platform serves semiconductor designers and chip manufacturers seeking to accelerate the design of advanced analog circuits.

8 investors

Atomic Alchemy builds privately-owned nuclear reactors dedicated to radioisotope production, including Molybdenum-99 used in most nuclear medicine procedures. It aims to supply radiopharmaceutical materials for diagnostic imaging, biological tracers, and cancer treatments.

8 investors

Auriga develops electromagnetic launch technology used for ground-based hypersonic testing, deployment of unmanned systems and effectors, missile defense interceptors without rocket motors, and responsive launch to low Earth orbit. It serves defense and commercial space customers with platforms that replace conventional propulsion and rocket first stages.

8 investors

Avicena develops microLED-based optical interconnect technology, including the LightBundle transceiver ICs that pair microLED emitters and photodetectors with multi-core fiber for high-speed chip-to-chip communications. Its products connect GPU clusters across multiple racks to enable scalable, energy-efficient data center and computing interconnects.

8 investors

Beam Therapeutics develops gene-editing medicines, particularly base editors and precision genome editing technologies, to create lifelong cures for patients with serious genetic diseases. The company works across multiple therapeutic areas to advance precision medicine treatments at the molecular level.

8 investors

Bifrost provides GPU-accelerated simulation and synthetic data generation for physical AI systems, enabling teams to train, test, and evaluate robotic and autonomous systems using photorealistic, multi-modal sensor data.

8 investors

Carbyon develops direct air capture technology to remove CO2 from the atmosphere and supply it as circular CO2. The company is working toward its first demonstrator and scaling manufacturing capacity for its capture systems.

8 investors

Cascade Space develops software tools and infrastructure for designing, building, testing, and operating spacecraft communication systems. The company serves aerospace and space companies seeking to accelerate development with reduced team requirements.

8 investors

ClearMotion develops active suspension systems for automotive vehicles. The company manufactures production-ready suspension technology with a focus on serving the automotive industry.

8 investors

Cloudline develops autonomous airships powered by solar and battery technology for carbon-free aerial operations. The company targets applications requiring extended range and endurance with reduced operating costs compared to traditional aviation.

8 investors

Conception develops stem cell technology to create functional reproductive cells in the laboratory, enabling in-vitro gametogenesis as a solution for individuals facing biological and medical fertility barriers.

8 investors

Concerto Bio generates large-scale ecological datasets on microbial communities and uses them to develop microbe-based consumer health products for applications such as skincare, chronic disease, and nutrition. Its approach combines high-throughput experimental data generation with predictive modeling to make microbial communities engineerable.

8 investors

Constellr designs and operates a microsatellite constellation delivering thermal satellite intelligence for defense and government operations. The company provides precise surface temperature monitoring and multi-spectral imaging from space for mission-critical applications across Europe and globally.

8 investors

Correlia Biosystems, a UC Berkeley spinoff, develops microscale tools for rapid quantification of biomolecules from microliter-scale blood samples, aimed at generating large proteomic data sets for pharmaceutical companies. Its applications span next-generation proteomics research and point-of-care diagnostics.

8 investors

CREW is a Yale spinout that adds calcium carbonate (ground limestone) to wastewater treatment plants to intensify biological treatment, cut chemical costs, and permanently remove carbon dioxide. It serves municipal and industrial wastewater utilities while also selling verified carbon removal to corporate carbon buyers.

8 investors