Deep Tech Startups

Rayni builds an AI assistant for scientific instruments that answers only from verified sources, cites every claim, and learns a lab's specific procedures. It serves scientists and researchers in labs, field, and enterprise settings within the scientific instrumentation industry.

2 investors

Re:Build Manufacturing operates a network of specialized manufacturing facilities across the United States, providing design, engineering, prototyping, and production services for embedded systems, composites, chemical processes, and medical consumables. The company supports product development at scale with over 1,200 technical experts and advanced manufacturing capacity.

2 investors

Reaction Dynamics develops the Aurora rocket using a patented hybrid rocket engine to provide dedicated, cost-effective launches for small-satellite operators into Low Earth Orbit. Based in Canada, it aims to establish sovereign Canadian launch capability, with suborbital and orbital launches planned for 2026 and 2028.

2 investors

Reactory develops patented maturation technology that accelerates spirit aging from decades to days while reducing production costs and environmental impact. The technology enables distilleries to produce aged spirits at scale using controlled maturation with minimal material waste and energy consumption.

2 investors

RealSeq Biosciences develops RNA fragmentomics technology for advanced diagnostics, enabling detection and analysis of RNA fragments to discover new biomarkers and provide deeper insights into disease. The company serves the healthcare and diagnostics industry by unlocking previously inaccessible biological information from RNA.

2 investors

Reaxbio develops a chemoproteomics platform that identifies and targets novel protein sites for drug discovery across disease-relevant biological contexts. The platform enables small molecule discovery for virtually any protein using proprietary chemical tools and high-throughput screening capabilities.

2 investors

REDLattice is a U.S.-owned defense technology company that develops cyber solutions and tools for the intelligence community, law enforcement, and military organizations. The company provides digital access capabilities, vulnerability identification, and offensive cyber operations tailored for classified and high-risk environments.

2 investors

Refamo provides fatigue assessment technology for welded steel structures and assets operating under dynamic loads, enabling lifecycle monitoring and durability optimization.

2 investors

Reflector provides a machine learning platform that predicts functional responses of small molecules across diverse cellular contexts to prioritize drug candidates earlier in the discovery process. The tool helps pharmaceutical teams assess phenotypic effects, identify off-target liabilities, and classify mechanisms of action before committing to expensive downstream experiments.

2 investors

Reflex Aerospace manufactures rapid-delivery, customizable satellite platforms for commercial and government missions, leveraging advanced manufacturing techniques to reduce development timelines. The company serves mission operators and payload integrators globally with ESPA-class, ITAR-free satellite solutions capable of supporting complex payloads.

2 investors

Regor is a drug discovery company that uses a computational platform (rCARD) to identify and optimize preclinical small-molecule candidates in metabolism, oncology, and immunology, which it licenses to pharmaceutical companies for clinical development. Its pipeline includes RGT-075, an oral GLP-1R agonist for obesity and type 2 diabetes, and next-generation CDK inhibitors for breast cancer.

2 investors

Rekursiv.ai builds autonomous systems of AI models that act as "AI Scientists," forming hypotheses, designing and running experiments, and discovering new knowledge such as novel machine learning algorithms. The company targets research and AI development, aiming to scale automated scientific discovery.

2 investors

Relativity Networks develops Hollow Core Fiber (HCF) optics that replace glass with air to move data nearly 50% faster, reducing latency over distance. The technology targets hyperscalers and data center operators, allowing them to build facilities in power-rich or renewable-energy locations away from constrained urban grids.

2 investors

Relling builds and deploys robotic manufacturing workcells as pre-qualified products rather than custom engineering projects, reducing installation time and enabling faster automation deployment on American factory floors. The company sells integrated workcells that are software-reconfigurable for different parts, addressing the gap between advancing robotics technology and slow, artisanal deployment practices.

2 investors

remynd develops first-in-class oral treatments to restore and preserve neuronal function in patients with age-related neurodegenerative diseases such as Alzheimer's and Huntington's, and runs a discovery program targeting mitochondrial dysfunction in ALS. It also operates a contract research organization (CRO) that uses proprietary mouse models to help pharmaceutical companies in the US, Europe and Japan assess experimental neurodegenerative disease treatments.

2 investors

Repertoire's Decode platform focuses on mapping the immune synapse — the interactions between T cell receptors, epitopes, and HLA molecules — to support the development of medicines targeting cancer and other diseases. It operates in immunology-based drug discovery and therapeutics.

2 investors

Resonant Technologies Group is a company creator and accelerator that builds and operates ventures based on "Resonance Physics," spanning health diagnostics, frequency-based wellness products, immunotherapy, agriculture, audio hardware, and mineral extraction. Its operating companies include Sonaphi, Field Futures, Sourcewave, Divina Biotech, UpTerra, Form Audio, and Manna Vitality, focused on human health, energy, and the environment.

2 investors

Restack builds a framework for developing reliable and accurate AI agents. It targets developers and engineering teams working on agentic applications.

2 investors

Retym develops DSP (digital signal processing) and ADC/DAC technologies for AI infrastructure and cloud connectivity, with expertise in analog design, error correction, and optical communications.

2 investors

Rev Genomics is a plant biotechnology company that develops novel plant cultivars. It serves breeders, growers, and retailers looking to differentiate in high-value markets.

2 investors

REVCOO develops and industrializes CarbonCloud®, a proprietary retrofit-ready technology that captures, purifies, and conditions CO₂ directly from industrial post-combustion flue gases into ready-to-use high-purity liquid CO₂. It serves industrial companies pursuing Net Zero decarbonization pathways.

2 investors

A space technology company developing advanced propulsion and space systems. The company is led by experienced aerospace and defense professionals and advised by former government officials and leading space researchers.

2 investors

Rgenta develops orally available small molecule therapies that target RNA to address diseases previously considered undruggable, with programs in oncology (targeting proteins such as MYB in solid tumors and hematologic cancers) and central nervous system repeat expansion disorders like Huntington's disease. It operates in the RNA-targeted drug development space.

2 investors

RheaVita manufactures scalable freeze-dryer systems for pharmaceutical and vaccine development, ranging from R&D models to GMP-compliant production units. The company serves pharmaceutical and biotech manufacturers seeking to accelerate drug development and lyophilization scaling.

2 investors