Deep Tech Startups

Luna Space develops StarLogic, an autonomous vision-based navigation and guidance system for spacecraft rendezvous, docking, and proximity operations. The system serves space applications including in-orbit servicing, active debris removal, and formation flying for distributed spacecraft.

2 investors

Lungpacer Medical develops neurostimulation technologies for critical care, focused on ventilator weaning to improve outcomes for patients. Its offerings are built by a team of clinical and engineering experts.

2 investors

Lyrebird develops speech synthesis and voice cloning technology for developers, originating from research at the MILA lab at the University of Montréal.

2 investors

Lyric Bio develops tissue-engineered bioreactors that use a proprietary laser-printed cellular substrate to grow high-density human cells and produce human immunoglobulin (IvIg, ScIg) from a single donor. The company aims to reduce Ig therapy's dependence on blood and plasma donations and enable scalable manufacturing of complex donor-derived biologics.

2 investors

MXR develops Marso Measure, a photogrammetry-based software for capturing high-fidelity 3D assets and measuring physically based rendering (PBR) material maps such as albedo, diffuse, roughness, specular, metallic, and normal. The tool reconstructs geometry and processes measured PBR maps locally using any co-located light system.

2 investors

Mach42 offers a cloud-based platform that uses neural networks to accelerate simulation and design optimization across complex engineering problems. The platform simplifies collaborative design workflows by creating fast emulators that let teams explore design spaces and optimize outcomes orders of magnitude faster than traditional simulation.

2 investors

Maculaser develops a temperature-controlled retinal laser therapy to treat age-related macular degeneration, diabetic macular edema, and other retinal disorders by activating natural healing responses in eye cells. The company targets patients and healthcare providers globally for disease prevention and non-invasive retinal care.

2 investors

Maglut develops rare earth element purification technology, focusing on precision purification processes for domestic U.S. rare earth production.

2 investors

Magnitude Biosciences provides a high-powered imaging assay that measures mitochondrial health and age-related morphological changes using C. elegans muscle tissue as a model system. The service helps researchers and pharmaceutical companies assess whether test compounds protect against age-associated mitochondrial degradation.

2 investors

Magnopus develops the Connected Spaces Platform, an open-source, client-side library that enables developers to build interoperable, cross-reality, multi-user applications across web browsers, VR headsets, mobile AR apps, and gaming consoles. The platform provides standardized communication infrastructure and cloud services to support real-time collaboration and synchronized experiences in shared digital spaces.

2 investors

Magritek develops benchtop NMR spectrometers and related hardware for chemistry laboratories and research applications, enabling on-line monitoring of chemical reactions and analysis. The company serves academic and industrial research institutions requiring high-resolution nuclear magnetic resonance instrumentation.

2 investors

Makesense Technology develops navigation technology for people with visual impairments, enabling independent outdoor mobility. The Vector is a precision navigation tool designed for blind and partially sighted users.

2 investors

The company develops assistive technology to make the world more accessible and inclusive. The team combines expertise in mechanical engineering, machine vision, software development, and user research.

2 investors

Mantic is an AI forecasting platform that generates and manages prediction questions. The page references Mantic as a tool used to build a dashboard of forecasting questions, suggesting it combines AI-generated forecasting capability with human question-writing expertise.

2 investors

Marginum develops a fluorescence-based optical tissue monitoring technology that detects tumour cells from surgical suction waste in near real-time to help surgeons perform more accurate resections during cancer surgery. The system integrates into existing surgical workflows and is aimed at oncological surgery to reduce reoperations and improve patient outcomes.

2 investors

MarineLabs develops high-resolution coastal sensor networks and marine data intelligence for ocean monitoring and climate resilience. The company operates a fleet of sensors across North America to provide real-time oceanographic data for marine mobility and coastal risk assessment.

2 investors

Marlinspike is a firm whose team includes advisors with senior U.S. national security and intelligence backgrounds. The page profiles an advisor who served as the CIA's Chief Operating Officer, but provides no direct description of the company's own products or services.

2 investors

Marvel Fusion develops a laser-based inertial fusion energy concept, combining a proprietary fast ignitor approach with innovations in lasers, targets, and power plant technology to enable commercial fusion power generation. The company works with strategic partner Siemens Energy and industrial suppliers across Europe and the United States.

2 investors

TEDCO's Federal Engagements department connects Maryland small businesses with federal laboratories to commercialize federally developed technologies, offering R&D training, matching funds, and legal, accounting, and financial advisory services. It operates in Maryland's entrepreneurial ecosystem, working with federal labs on technology transfer and cross-sector collaboration.

2 investors

Mater-AI designs novel thermoelectric materials using AI, physics-based modelling, quantum methods, and lab validation, aiming for higher efficiency without toxic or rare earth elements. Its materials target power generation and solid-state cooling across automotive, industrial systems, and IoT applications.

2 investors

MaterialGate manufactures and sells single-molecule dielectrics, a materials technology developed for electronic device applications. The company also provides technical licensing and functional exploration services to support the development of new material capabilities.

2 investors

Math Inc. develops AI systems for autoformalization, including Gauss, an agent that formalizes mathematical proofs, aimed at achieving verified superintelligence. It also runs the Veritas Fellowships for mathematicians and releases tools such as OpenGauss and the FormalQualBench benchmark.

2 investors

MatNex is a materials design company that uses first-principles computation, machine learning, and materials engineering to design new materials to customer-specified performance and cost targets, and owns the resulting material IP. It is starting with rare-earth-free magnets for industries such as EVs, wind turbines, data storage, and electronics, with plans to expand into fluids, semiconductors, batteries, and superconductors.

2 investors

Matrisome Bio is an oncology biotech developing therapies based on extracellular matrix (ECM) biology, using a protein engineering platform to target the tumor microenvironment. Its work spans multiple modalities including radioligand therapies.

2 investors