Biotech Startups

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Aponia Laboratories is a specialized pharmaceutical company developing topical prescription and over-the-counter pain relief products based on ibuprofen for the NSAID segment of the arthritis pain market. Its products have completed formulation development and non-clinical studies and are undergoing FDA-guided clinical trials.

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Applied Biological Laboratories develops antiviral biotechnology treatments targeting respiratory viruses using a patented biologic platform that combines host-directed immune modulation and microbe-directed mechanisms. The company conducts research using human respiratory organoids to identify and develop antiviral and anti-inflammatory therapeutic solutions.

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Applied BioMath (now part of Certara) provides Quantitative Systems Pharmacology (QSP) consulting services that combine computational modeling with experimental data to address drug development challenges such as first-in-human dose selection. Its work spans therapeutic areas including oncology, inflammation and immunology, and neurodegenerative diseases, serving biopharmaceutical drug developers.

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AptamiR Therapeutics is a US biotechnology company in pre-clinical development of microRNA-based oligonucleotide therapeutics (antagomirs), including miR-22-3p drug candidates for cardiometabolic disorders such as obesity, diabetes and fatty liver disease (MAFLD/MASH) and candidates for epithelial ovarian cancer. Its approach modulates multiple target genes simultaneously to address complex metabolic diseases and cancer.

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Aquestive Therapeutics develops and commercializes oral film drug formulations and other novel delivery systems for treatments in neurology, psychiatry, and emergency care, operating manufacturing facilities in Indiana that produce both licensed pharmaceutical products and proprietary candidates for regulated markets including the U.S., EU, and Australia.

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Aqur Biosciences is a bioscience company developing drug therapies for cardiovascular health, including treatments for hypercholesterolemia. Its lead candidate is a PCSK9-pathway modulator aimed at people at risk of cardiovascular disease.

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Araceli Biosciences builds High Content Imaging platforms and software that provide real-time image analysis and analysis-ready data for therapeutic and drug discovery research. Its tools serve researchers screening compounds, pairing imaging hardware with AI-driven analysis to speed candidate selection in the drug discovery pipeline.

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Arc Techtonics develops orthopedic trauma medical devices, with a flagship CounterArc Plating System built on patented anatomic multiplanar technology for complex fracture repair. The plates use continuous arc struts, orthogonal screw fixation, and a wedge window design intended to improve fixation strength and bone grafting for orthopedic surgeons.

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Oruka is a biopharmaceutical company developing monoclonal antibodies for plaque psoriasis, psoriatic arthritis, and other dermatologic and inflammatory conditions, aiming for high rates of disease clearance with as few as one or two doses per year. Its pipeline includes ORKA-001 and ORKA-002, both in clinical trials for moderate-to-severe plaque psoriasis.

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Arch Therapeutics develops the AC5 Advanced Wound System, a wound care product available in the USA for both government and non-government purchasers. The company operates in the medical device sector focused on wound management.

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Aridis Pharmaceuticals is a late-stage clinical biopharmaceutical company developing monoclonal antibody and small-molecule anti-infectives for life-threatening viral and bacterial respiratory infections. Its pipeline targets antimicrobial-resistant bacteria and viral pandemics, using a platform that discovers human monoclonal antibodies from convalescent patients.

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