Biotech Startups

Spartan Bioscience develops rapid, on-site DNA testing platforms designed for in-field diagnostic applications. The Canadian biotechnology company specializes in sample-to-result testing technology for infectious disease and molecular diagnostics.

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SpayVac develops a single-dose vaccine platform for fertility management in production animals, including applications for boar taint prevention in swine, population control in bison, and sterility in farmed fish. The company targets livestock producers seeking to reduce handling stress and labor while maintaining animal welfare and productivity.

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Specific Biologics develops in vivo genome editing therapeutics based on its Dualase editors, which use a two-site mechanism to remove, repair, or insert DNA sequences, with an initial focus on correcting expanded DNA repeats. Its pipeline targets CNS, lung, and liver genetic diseases using single AAV or lipid nanoparticle/polymer-encapsulated all-RNA delivery.

1 investor

Specto Photonics develops Brillouin spectroscopy instruments, including ultra-compact on-chip spectrometers and high-rejection optical filters, for non-contact, label-free measurement of the viscoelastic properties of living cells and tissues. Its modules integrate into standard microscopes and analytical instruments to enable 3D mechanical analysis for mechanobiology research.

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AI medical diagnostics company whose DeepView imaging platform predicts whether burns and other wounds will heal.

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Spectre Intelligence is building an AI-driven quantitative trading firm structured as a multi-strategy ("pod shop") hedge fund, where AI agents run and evolve trading strategies while the company deploys its own capital and learns from each trade. It currently operates pods focused on semiconductors and biotech.

1 investor

SpectronRx develops and manufactures theranostic and diagnostic molecular isotope products (radiopharmaceuticals), operating research and production facilities including cyclotron sites. The company serves the nuclear medicine market and is headquartered in the central US, with facilities in Fishers and South Bend, Indiana.

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SpeeDx develops PCR-based diagnostic tests for sexually transmitted infections that detect pathogens and antibiotic resistance markers, enabling clinicians to make informed treatment decisions. The tests are designed for use with standard laboratory equipment in clinical settings.

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Speratum Biopharma develops RNA interference (RNAi) therapeutics for cancer and other hard-to-treat genetic diseases, using its proprietary NoPass RNAi design platform and Nano-In nanoparticle delivery system. Its lead candidate, NM-198, is based on the tumor-suppressor microRNA miR-198 and targets multiple oncogenic pathways in solid tumors.

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Spero Therapeutics is a clinical-stage biopharmaceutical company developing next-generation immunology and inflammation medicines, particularly targeting patients with serious diseases and major treatment gaps. The company's lead program, SP001, is a novel anti-CD40L monoclonal antibody being advanced in IgG4-related disease and other immune-related conditions.

1 investor

SphereBio develops individualized cancer immunotherapies using engineered biological vesicles (OncoSpheres™) that capture a patient's own tumor antigens and deliver them into immune cells to train the immune system against cancer. The company combines biotechnology, synthetic virology, and AI to create individualized cancer vaccines manufactured without sequencing in under seven days.

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Spherix Global Insights provides independent syndicated market research and intelligence for pharmaceutical and biotech companies, combining primary research across physicians, patients, and payers with therapeutic expertise and AI-assisted execution. Its data supports commercial decisions and is used in investor reviews and board conversations.

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SphingoTec develops proprietary biomarkers for critical care diagnostics, addressing acute kidney injury, sepsis, and acute heart failure through partnerships with in vitro diagnostics companies and pharmaceutical firms. The company licenses its biomarker portfolio to global IVD partners to make clinical diagnostic products available worldwide.

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Spiber develops next-generation biomaterials based on structural protein technology, producing polymers through fermentation for applications across lifestyle, beauty, food, and healthcare products. The Japanese company operates a production plant in Thailand and a materials sales branch in Europe.

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Spidfier makes a self-contained lab-in-a-box that identifies fish species through automated DNA sequencing. Seafood producers and regulatory bodies use it to confirm what a product actually contains in minutes rather than days, supporting fraud detection and reduced waste.

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Developing non-surgical, non-opioid therapies for degenerative disc disease through targeted peptide injection.

1 investor

Spirovant is a gene therapy company developing treatments for cystic fibrosis and other respiratory diseases, including viral vector-based therapies for airway epithelia. It is based in Philadelphia's Life Sciences Corridor.

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SpliSense develops antisense oligonucleotides (ASOs) — small synthetic RNA-binding molecules — designed using proprietary algorithms for therapeutic applications including splicing modulation and gene silencing. The company focuses on inhaled ASOs delivered directly to the lungs for treating pulmonary and obstructive lung diseases with minimal systemic exposure.

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SPMED provides pharmacogenomics testing services and personalized drug therapy solutions, along with drug development and bioanalytical services for custom therapeutics.

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Spora discovers and cultivates wild fungal strains from pristine ecosystems, processing them with proprietary biotechnology and nanotechnology to create mycelium-based products. The company combines scientific research with ancestral knowledge from remote communities to develop sustainable, nature-inspired solutions.

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Spornado develops air sampling and detection equipment for fungal pathogens, serving environmental and industrial clients concerned with contamination monitoring and remediation. The company addresses sustainability through improved detection and management of fungal contamination in indoor and outdoor environments.

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Sporos Bioventures is a private biotechnology company that uses a portfolio approach to drug development in oncology, holding equity stakes in biopharma entities such as Tvardi Therapeutics and Sporos BioDiscovery. It is based in Houston, Texas.

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Spot Biosystems is a clinical-stage biopharmaceutical company developing non-viral gene therapies using extracellular vesicles as a delivery method. The company targets genetic diseases including muscular dystrophy and cardiac conditions.

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