AI & Machine Learning Startups

SIMPLEX QUANTUM develops AI-powered software libraries that analyze electrocardiogram (ECG) signals to detect cardiac abnormalities, monitor stress levels, and perform biometric authentication for healthcare and wellness applications. The company serves healthcare providers, diagnostic centers, and organizations seeking non-invasive cardiac monitoring and stress assessment solutions.

1 investor

Simplex Micro designs RISC-V microprocessor intellectual property, including scalable vector processors that range from 1 to 8-wide architectures. The company serves semiconductor and system-on-chip developers requiring high-performance CPU designs.

1 investor

SimpliCapital offers an AI-powered cash flow management platform that automates accounts receivable, accounts payable, cash forecasting, and integrated payment processing. It targets finance teams and CFOs, connecting to major ERPs and banks to provide real-time cash flow visibility and collections, payment, and forecasting tools.

1 investor

Simplifai builds agentic AI and software-as-a-service solutions aimed at regulated industries such as insurance, banking, and financial services. The company provides AI-driven automation tools for enterprise use cases.

1 investor

Simplifai builds AI-based traffic control systems that flexibly manage road traffic to reduce congestion and other traffic-related problems. Developed with UK universities and government transport bodies, the technology applies a form of artificial intelligence (originally used for autonomous vehicle navigation) to transport and traffic management.

1 investor

Simply Silicon builds bare metal inference compute by converting urban power capacity and connectivity into high-assurance data centres with private air-gapped fiber networks. It targets regulated and latency-sensitive customers such as banks, utilities, defence, government, and emergency services, as well as high-security AI workloads, with a flagship site in Calgary and a pipeline across North America and Europe.

1 investor

Simply.TV builds metadata and content discovery solutions for TV platforms, streaming services, and operators in the entertainment industry. The company serves media operators across Europe, Latin America, and North America with metadata to power content discovery at scale.

1 investor

Simppler provides a HR technology recruitment platform and best practices guidance that helps companies streamline hiring workflows using advanced tools like applicant tracking systems, AI-powered screening, and structured interview processes. The company serves mid-sized and growth-stage organizations looking to reduce time-to-hire and improve recruitment efficiency while maintaining fair, bias-aware hiring practices.

1 investor

Simreka provides an AI-driven R&D platform for chemicals, materials, and manufacturing companies, using virtual experimentation and simulation to accelerate product formulation and process discovery. The platform includes a domain-specific language model trained on chemical patents and technical literature, with deployment options for cloud or on-premise environments.

1 investor

Altair leverages high-performance computing and data science to solve complex engineering and scientific challenges for customers across industries. The company was acquired by Siemens, the leading industrial software company.

1 investor

SimSpace provides a cyber range platform where security teams train, test, and operationalize AI agents and human analysts in a realistic digital replica of their production environment. Its AI Proving Grounds lets teams continuously stress-test agentic SOC defenses against LLM-based threats.

1 investor

SimTutor is a platform for building interactive, simulation-based training that lets organizations create hands-on learning experiences using templates, AI-assisted tools, or existing content and deliver them via an LMS, direct link, or embed. It targets corporate use cases such as employee onboarding, safety and compliance, and leadership and soft-skills development, with tools to track learner progress and performance.

1 investor

SIMUFORM offers SIMILIA AI, software that connects and searches technical engineering data from CAD, PDM, PLM and ERP systems, including 3D geometry and attribute search without prior classification. Aimed at manufacturing companies' design, purchasing, production and calculation departments, it runs as an on-premise (non-cloud) solution to reduce duplicate parts and speed up workflows.

1 investor

Simulacra is a platform designed to make metaverse and extended reality (XR) technology accessible and easier to use for mainstream audiences. The company, produced by REM5 Studios, operates as an innovation center providing equitable access to AR, VR, XR, and Web3 technologies.

1 investor

Simulithic runs AI agent simulations that model real user cohorts—built from a product's last 90 days of session data—to predict how experiments and product variants will perform before shipping to real users. It integrates with session tools like Clarity and PostHog and returns predicted metrics such as lift, confidence intervals, churn, and activation for product and growth teams.

1 investor

SinConta is a Mexican online accounting service that files automatic monthly and annual tax declarations, generates unlimited CFDI 4.0 invoices, and detects deductions using an AI assistant, combined with a dedicated accountant reachable via WhatsApp. It targets freelancers and independent professionals in Mexico and offers fiscal regularization to help clients get up to date with the SAT tax authority.

1 investor

Sindarin provides a platform and API for building voice AI interfaces, letting developers configure conversational "Personas" via a web platform or in code. The product focuses on low-latency, natural conversational voice models for real-time speech interactions.

1 investor

Sindri AI builds governed "Agentic Execution AI" systems that turn manual, multi-step operational processes into automated workflows with human oversight and audit trails for heavy-asset, capital-intensive industrial organizations. Its deployments cover non-conformance resolution, bid compliance, transmittal processing, and capital project governance across capital projects, maintenance and reliability, and supply chain operations.

1 investor

Sindyk is an IT services firm that builds custom software and designs scalable cloud infrastructure on AWS, Azure, and Google Cloud for businesses. It also offers data analytics and machine learning, IoT integration, and proprietary platforms for user identification and mobile site performance.

1 investor

SineWave Ventures is a venture capital firm that invests in data, analytics, networking, cybersecurity, and computing technologies, with a focus on companies bridging commercial and public-sector (government, defense, and intelligence) markets. It backs early-stage companies developing AI/ML developer tooling, adaptive networks, zero-trust security, and high-performance computing.

1 investor

SingleComm is a communications platform incubated by Loeb.NYC, a venture lab founded by veteran entrepreneurs.

1 investor

SingleFile provides entity compliance management for investment organizations managing complex structures like fund vehicles, SPVs, portfolio companies, and holding companies across all U.S. states. The platform automates annual report filing, registered agent services, foreign qualification management, and centralizes document storage and entity tracking.

1 investor

Singular Machines develops AI-native engineering tools for designing complex machines, facilities, and infrastructure in the advanced manufacturing sector.

1 investor

Singularities develops machine learning and deduction technology that models customer beliefs and behaviors for supply chain optimization and personalized consumer finance applications.

1 investor