/Investor DB

Empactful Capital

Venture capital

Philadelphia · Seed–Series B · 29 people tracked

Also known as EMPACTFUL CAPITAL LLC

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Investment thesis

Empactful Capital invests in healthcare technology companies with proprietary technology and differentiated IP, favoring SaaS models but also backing tech-enabled services. It targets businesses at a critical inflection point, typically entering at $3-10M ARR and supporting them toward $25M-$100M revenue over a 3-5 year hold. The firm looks for evidence of product-market fit through proven financial ROI, pilots converted into multi-year enterprise contracts, and $3M+ ARR. Leveraging decades of operating experience building healthcare's leading organizations, the team acts primarily as a lead investor and applies a differentiated value-creation model to help companies accelerate sustainable growth and reach multiple exit options.

Source: firm website, verified Sep 29, 2026.

Stage
Seed–Series B
Check
$1M – $7M
HQ
Philadelphia, Pennsylvania, US
Leads rounds
Leads
Instruments
Equity
Founded
2016
Private fund assets
$63.2M
VC funds
2
Tracked investments
5
Acquisitions
1

Team · 29 people

from the firm's website & public directories
Shawn Hamilton· COO, Optum Innovation
Frank DeTrane· Gastroenterologist, Mary Washington Health System
Mike DeTrane· Senior Directorin

8 people who came through Empactful Capital went on to found or lead other companies.

What they invest in

from 3 of 5 portfolio companies

Healthtech ×2SaaS ×2AI & Machine Learning ×1Digital Health ×1Enterprise Software ×1Logistics & Supply Chain ×1

HQs:United States×5

Investments · 5 tracked

founders shown can be your intro path

By year:2024 · 12023 · 12022 · 13 dated

Vellumvellum.health✓ verified

Vellum Health is a platform for on-demand intravenous treatment and care delivery designed to shift medical services outside hospital settings.

AI & Machine LearningDigital HealthHealthtechSaaSSan Francisco, US

Tyler(Founder)Dr. HaqLeia

Co-investorsFCA Venture Partners

Thoroughcare, Inc.inOct 2024

ThoroughCare is a Pittsburgh-based SaaS platform for care coordination and value-based care delivery for healthcare providers.

Pittsburgh, US

Daniel Godla(CEO)Earl Hutz(COO)in

Board seatSal DeTrane· per SEC Form D

Co-investorsCypress Growth Capital

FIRSTfirstdelivery.cominSeed

FIRST provides a delivery platform that aggregates orders from multiple channels into a single interface, routes them to appropriate delivery providers, and offers post-purchase management tools for businesses.

Enterprise SoftwareLogistics & Supply ChainSaaSPhiladelphia, US

Andrew Nakkache(Founder)inMichael Paszkiewicz(Founder)inRupert Goodman(Founder)Jonathan Cameron(Vice President Strategy and Partnerships)Kyle Harris(Recruitment Specialist)

Co-investorsY CombinatorAgrolimen VenturesAltaclub VCAltaIR CapitalAvalanche VCBen Franklin Technology Partners+6 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Care Continuity, Inc.Veda Data Solutions, Inc.

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Frequently asked questions

How many investments has Empactful Capital made?
Empactful Capital has 5 tracked investments, 1 of which have exited.
What stage does Empactful Capital invest at?
Empactful Capital invests at the Seed, Series A, Series B stages.
What is Empactful Capital's typical check size?
Empactful Capital typically writes checks of $1M – $7M.
What sectors does Empactful Capital focus on?
Empactful Capital focuses on Digital Health, Healthtech, SaaS.
Where is Empactful Capital located?
Empactful Capital is headquartered in Philadelphia, US.
Does Empactful Capital lead rounds?
Yes, Empactful Capital leads investment rounds.

Media · Podcasts & interviews

featuring the team

#22: Hands-on Investing and Pitching Advice With Empactful Capital Managing Director Sal DeTrane

Decoding Healthcare Innovation · Sal DeTrane

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