Fundraising Fox
Chain Reaction
Angel networkBoston · Pre-Seed–Seed · 19 people tracked
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Investment thesis
Chain Reaction provides early-stage investors with curated access to blockchain startups through monthly meetings featuring vetted pitches, collaborative due diligence conducted with investors from varied industries, and a nationwide network of accredited investors and blockchain leaders. The platform emphasizes fast decision cycles and peer-driven evaluation to enable individual investors to build differentiated early-stage blockchain portfolios.
Source: firm website, verified Oct 1, 2026.
Team · 19 people
from the firm's website & curatedFounder mafia
2 people who came through Chain Reaction went on to found or lead other companies.
What they invest in
from 14 of 19 portfolio companiesCrypto & Web3 ×9Fintech ×8SaaS ×6Enterprise Software ×4AI & Machine Learning ×2B2B Marketplaces ×2Cloud Computing ×2Gaming ×2
HQs:United States×14
Who they back
founder profiles across 12 portfolio companiesFounding team size:solo founder×72 founders×5
Accelerator rootsportfolio companies that came through a program
Investments · 19 tracked
founders shown can be your intro pathBy year:2021 · 12014 · 12 dated
Beamable is an open, extensible game server platform that enables game developers to rapidly build and operate online games and virtual worlds.
Cloud ComputingDeveloper ToolsGamingSaaSBoston, US
Ali El Rhermoul(Founder)in
Co-investorsCompanyon VenturesGrandBanks CapitalAdvancit CapitalJoint EffectsREMUS CapitalVitalStage Ventures+4 more
Skybox AI is an AI tool that generates skybox environments and HDRI assets for game studios and creative professionals.
AI & Machine LearningCrypto & Web3GamingIndianapolis, US
Marguerite deCourcelle(Executive Officer, Director)in
Co-investorsDAO JonesFulgur VenturesNarcissus VenturesRed Beard VenturesTechstars6th Man Ventures+3 more
Iain Fraser(Founder)in
Co-investorsAlumni VenturesFoundation CapitalLightShed VenturesPJCRaptor Group
Corechain provides a B2B payments platform that streamlines paperless payments and supply chain financing to help suppliers unlock working capital from unpaid invoices.
B2B MarketplacesEnterprise SoftwareFintechSaaSNew Haven, US
Chris Aguas(Founder)inRandy Shuken(Director)Thomas G Romary(Executive Officer, Director)
BoardSteve Reale(Director)inJoseph Giordano(Director)in
Co-investorsBloccelerate VCNext Coast VenturesUlu VenturesConnecticut InnovationsMotivate Venture CapitalNew Form Capital
DigiBuild is a construction procurement platform that helps general contractors, subcontractors, and property owners source materials, reduce costs, and maintain project timelines.
AI & Machine LearningB2B MarketplacesConstruction TechEnterprise SoftwarePropTechSaaSMiami, US
Robert Salvador(Founder)inApril Moss(Co-Founder & former COO / Chief Customer Officer)inIvan Franco(Founder)in
Co-investorsPICUS CAPITALDraper AssociatesCathexis VenturesEmerging VenturesHelium-3 VenturesNeer Venture Partners+10 more
EirSystems builds medication management infrastructure for healthcare providers and EHR platforms, focusing on electronic medication administration records and opioid prescription monitoring across long-term care, behavioral health, and post-acute settings.
Digital HealthEnterprise SoftwareHealthtechMedical DevicesSaaSChattanooga, US
Robert Newman(Executive Officer, Director, Promoter)inRyan Seaberg(Co-Founder)Tyler Seaberg(Executive Officer, Director, Promoter)
Co-investorsAtlanta Technology AngelsSolas BioVentures
Gilded is a crypto payments and invoicing platform that helps finance teams manage accounts payable and receivable workflows using blockchain-based transactions.
Crypto & Web3FintechNew Orleans, US
Co-investorsAlumni VenturesNew Orleans Startup FundRed Beard VenturesTechstars
Boston, US
Chris Yim(Executive Officer, Director)Kyle Powers(Executive Officer, Director)Yush Gupta(Director)
Co-investorsEntrepreneurs Roundtable Accelerator (ERA)Gossamer CapitalLightning VenturesNew Layer CapitalSprint Vc
New Silver is a tech-enabled real estate lending platform offering fix-and-flip, ground-up construction, and 30-year rental loans to U.S. real estate investors, with online loan approval in under five minutes.
FintechPropTechSaaSWest Hartford, US
Kirill Bensonoff(Co-founder and CEO)inAlex Shvayetsky(Co-Founder and Head of Risk)in
NODE40 provides digital asset reporting infrastructure that reconstructs transaction-level history to support cost basis, lot identity, and reconciliation, producing outputs that can be traced and defended under audit or tax review.
Crypto & Web3FintechSaaSAlbany, US
Perry Phillip Woodin(CEO)Sean David Ryan(CTO)
Co-investorsWalnut Venture Associates
Paperchain is a media-finance startup offering online creators instant payments against their streaming revenue.
Crypto & Web3FintechStaten Island, US
Co-investorsChaos VenturesTechstarsMotivate Venture Capital
RoundlyX offered a service that rounded up spare change to invest into cryptocurrency holdings held on users' chosen exchanges.
Crypto & Web3FintechRichmond, US
Alex Euler(Director)William Trible, III(Director)Andrew Elliott(Executive Officer, Director)
Co-investorsSound Media VenturesAllied Venture PartnersBlockchain Founders FundGaingelsMCMA Ventures, LLCOrange DAO
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Play-to-earn game where users earn cryptocurrency using chicken NFTs to battle.
William Wu(Founder)in
Co-investorsAlpha Moon CapitalAvisa VenturesBluewheel CapitalGraviton FundOIG Capital (Oracles Investment Group)SWGI Ventures (SWISS GEM INVESTMENTS)+1 more
Trustware provides programmable routing infrastructure that enables decentralized applications, institutions, and users to accept deposits from any blockchain by automatically routing and settling assets across chains with minimal integration effort.
Cloud ComputingCrypto & Web3Boston, US
Garett Curran(Founder)in
Co-investorsTechstars
Web3 Enabler builds Salesforce-native blockchain applications, distributed on the Salesforce AppExchange, that let businesses accept stablecoin payments, send global payments, and track client crypto holdings.
Crypto & Web3Enterprise SoftwareFintechHollywood, US
Alexander Michael Hochberger(Executive Officer, Director)Peter Hubshman(Executive Officer, Director)
BoardAlexander Smart(Director)
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
CrebitpayTonestone
Exits · 2
2 acquisitions · showing 1Gildedacq. by Bitwave
Portfolio news
latest coverage across their companiesWeb3 Enabler · web3enabler.com · Apr 29, 2025
Frequently asked questions
- How many investments has Chain Reaction made?
- Chain Reaction has 19 tracked investments, 2 of which have exited.
- What stage does Chain Reaction invest at?
- Chain Reaction invests at the Pre-Seed, Seed stages.
- What sectors does Chain Reaction focus on?
- Chain Reaction focuses on Crypto & Web3.
- Where is Chain Reaction located?
- Chain Reaction is headquartered in Boston, US.
- Does Chain Reaction lead rounds?
- Chain Reaction typically participates in rounds rather than leading them.
- Who does Chain Reaction co-invest with?
- Chain Reaction most often shares deals with Techstars, Alumni Ventures, Red Beard Ventures, among 44 tracked co-investors.
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