Chain Reaction
Angel networkBoston Β· Pre-SeedβSeed
Investment thesis
Chain Reaction provides early-stage investors with curated access to blockchain startups through monthly meetings featuring vetted pitches, collaborative due diligence conducted with investors from varied industries, and a nationwide network of accredited investors and blockchain leaders. The platform emphasizes fast decision cycles and peer-driven evaluation to enable individual investors to build differentiated early-stage blockchain portfolios.
Source: firm website, verified Aug 6, 2026.
What they invest in
from 14 of 20 portfolio companiesCrypto & Web3 Γ9Fintech Γ8SaaS Γ5Enterprise Software Γ3AI & Machine Learning Γ2Cloud Computing Γ2Gaming Γ2PropTech Γ2
HQs:United StatesΓ11
Investments Β· 20 tracked
founders shown can be your intro pathCo-investorsAlumni VenturesAnaxagoBasecamp FundBlue InCube VenturesBridgeTower CapitalChasing Rainbows+26 more
Beamable provides backend infrastructure and tools for game developers, offering instant services for multiplayer/MMO, commerce, leaderboards, social features, and content with native Unity and Unreal SDKs.
Cloud ComputingDeveloper ToolsGamingBoston, US
Co-investorsAdvancit CapitalCompanyon VenturesGrandBanks CapitalJoint EffectsREMUS CapitalBoston Seed Capital
Skybox AI is an AI tool that generates skybox environments and HDRI assets for game studios and creative professionals.
AI & Machine LearningCrypto & Web3GamingIndianapolis, US
Marguerite deCourcelle(Executive Officer, Director)
Co-investorsNarcissus VenturesRed Beard VenturesTechstarsAnimoca Brands
Co-investorsLightShed VenturesPJCRaptor Group
CoreChain provides an embedded B2B payments and supply chain finance platform that lets vendors be paid digitally, reduces fraud risk, and replaces paper checks.
Enterprise SoftwareFintechSaaS
DigiBuild is a construction procurement platform that helps general contractors, subcontractors, and property owners source materials, reduce costs, and maintain project timelines.
AI & Machine LearningB2B MarketplacesConstruction TechEnterprise SoftwarePropTechSaaSMiami, US
Robert Salvador(Founder)inIvan Franco(Founder)in
Co-investorsPICUS CAPITALDraper AssociatesCathexis VenturesHelium-3 VenturesNeer Venture PartnersY Combinator+2 more
EirSystems Inc. develops EirMAR, a medication-management platform offering electronic medication administration (eMAR), EPCS-ready e-prescribing, controlled-substance inventory, bed and census tracking, automated reporting, and UB-04 billing.
Digital HealthHealthtechSaaS
Co-investorsAtlanta Technology AngelsSolas BioVentures
Gilded is a crypto payments and invoicing platform that helps finance teams manage accounts payable and receivable workflows using blockchain-based transactions.
Crypto & Web3FintechNew Orleans, US
Co-investorsNew Orleans Startup FundRed Beard VenturesTechstars
Co-investorsEntrepreneurs Roundtable Accelerator (ERA)Gossamer CapitalNew Layer CapitalSprint Vc
New Silver is a tech-enabled real estate lending platform offering fix-and-flip, ground-up construction, and 30-year rental loans to U.S. real estate investors, with online loan approval in under five minutes.
FintechPropTechSaaSWest Hartford, US
Kirill Bensonoff(Co-founder and CEO)inAlex Shvayetsky(Co-Founder and Head of Risk)in
NODE40 provides digital asset reporting infrastructure that reconstructs transaction-level history to support cost basis, lot identity, and reconciliation, producing outputs that can be traced and defended under audit or tax review.
Crypto & Web3FintechSaaSAlbany, US
Perry Phillip Woodin(Executive Officer)Sean David Ryan(Executive Officer)
Co-investorsWalnut Venture Associates
Crypto & Web3FintechStaten Island, US
Co-investorsChaos VenturesTechstars
RoundlyX offered a service that rounded up spare change to invest into cryptocurrency holdings held on users' chosen exchanges.
Crypto & Web3FintechRichmond, US
Alex Euler(Director)William Trible, III(Director)Andrew Elliott(Executive Officer, Director)
Co-investorsSound Media VenturesBlockchain Founders Fund
Play-to-earn game where users earn cryptocurrency using chicken NFTs to battle.
Co-investorsAlpha Moon CapitalGraviton FundSWGI Ventures (SWISS GEM INVESTMENTS)
Trustware provides programmable routing infrastructure that enables decentralized applications, institutions, and users to accept deposits from any blockchain by automatically routing and settling assets across chains with minimal integration effort.
Cloud ComputingCrypto & Web3Boston, US
Garett Curran(Founder)in
Co-investorsTechstars
Web3 Enabler builds Salesforce-native blockchain applications, distributed on the Salesforce AppExchange, that let businesses accept stablecoin payments, send global payments, and track client crypto holdings.
Crypto & Web3Enterprise SoftwareFintechHollywood, US
Alexander Michael Hochberger(Executive Officer, Director)Peter Hubshman(Executive Officer, Director)
BoardAlexander Smart(Director)
Exits Β· 1
IPOs and acquisitions across the tracked portfolioGildedacq. by Bitwave
Portfolio news
latest coverage across their companies
Gilded Β· theglobeandmail.com Β· Jul 13, 2026
TrustWare Β· trysignalbase.com Β· Oct 21, 2025
Frequently asked questions
- How many investments has Chain Reaction made?
- Chain Reaction has 20 tracked investments, 1 of which have exited via acquisition or IPO.
- What stage does Chain Reaction invest at?
- Chain Reaction invests at the Pre-Seed, Seed stages.
- What sectors does Chain Reaction focus on?
- Chain Reaction focuses on Crypto & Web3.
- Where is Chain Reaction located?
- Chain Reaction is headquartered in Boston, US.
- Does Chain Reaction lead rounds?
- Chain Reaction typically participates in rounds rather than leading them.
- Who does Chain Reaction co-invest with?
- Chain Reaction most often shares deals with Techstars, Companyon Ventures, Red Beard Ventures, among 61 tracked co-investors.
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