Y Combinator Winter 2016 (W16) Companies

Opentrons develops laboratory robots that automate scientific research tasks for scientists and research institutions. The company aims to democratize access to laboratory automation and increase the availability of robotic systems to accelerate discovery in life sciences.

11 investors

Outschool operates a marketplace for live online classes taught by independent instructors to children ages 3–18, covering both core subjects and interest-based topics. The platform serves homeschooled and traditionally schooled students across 183 countries.

4 investors

Patchwork Security provides automated security patch notifications and deployment for servers, targeting teams who need to manage system updates across infrastructure.

1 investor

Pathmind applies deep reinforcement learning to industrial simulations and digital twins, helping engineers optimize operations and supply chains with performance gains, and then implements these optimized policies in live systems.

1 investor

Pave AI provides automated marketing analytics for enterprises, SMBs, e-commerce businesses, and agencies to identify effective marketing strategies and optimize spending.

1 investor

Paystack provides payment processing services that allow businesses in Africa to accept credit card, debit card, bank transfer, and mobile money transactions through their websites and applications.

3 investors

Perlara is a biopharmaceutical company that develops treatments for ultra-rare genetic diseases using yeast-based disease modeling and drug repurposing strategies. The company operates as a full-stack drug development platform serving rare disease patients and families.

1 investor

Petcube makes internet-connected pet devices, starting with pet cameras, and operates a platform for curated pet products that use data analytics to provide insights into pet health and behavior. The company serves pet owners globally seeking modern pet care technology.

5 investors

PhysioHealth provides a health and wellness management system for corporations that incentivizes employee health behaviors while aiming to reduce organizational healthcare expenses.

1 investor

Plato was a community platform for engineering leaders and mentors, providing mentorship programs, leadership conferences, and networking events. The company was acquired by Coda in 2024 and has since been sunset as the parent organization evolved.

3 investors

PocketSuite is a mobile business management app for self-employed professionals and solopreneurs to manage clients, scheduling, and payments. The platform serves independent service providers across various industries in the United States.

1 investor

Podium provides an AI-powered customer engagement platform that automates appointment booking and lead conversion for local businesses across multiple industries, enabling 24/7 customer response and higher conversion rates.

5 investors

Meet Poppy was a marketplace that connected families with vetted caregivers for childcare services including babysitting, date nights, and backup care. The platform matched families based on children's ages, neighborhood, and compatibility, and ensured all caregivers completed background checks and held current CPR/First Aid certifications.

1 investor

1 investor

Pulpix provides AI-powered personalization software for online video platforms to customize the viewing experience for users.

1 investor

Quilt provides a data platform for life sciences teams to organize, manage, and collaborate on scientific data stored in AWS. The platform consolidates data across multiple sources, enables AI-powered search, and maintains compliance with regulatory standards including HIPAA and GxP requirements.

2 investors

Qvin develops the Q-Pad, an FDA-cleared diagnostic menstrual pad that collects menstrual blood samples for non-invasive health monitoring and disease diagnosis. The company uses biomarker analysis from menstrual fluid to serve healthcare organizations and diagnostic platforms in women's health diagnostics.

2 investors

Rappi is a delivery and logistics platform that connects merchants and delivery partners with millions of users across multiple countries in Latin America, offering immediate delivery services and payment opportunities for couriers.

20 investors

Real Artists develops a natively-built issue tracker designed for rapid performance on software development projects.

1 investor

Redspread provides a deployment tool that allows teams to move containerized applications to Kubernetes clusters via command line. It targets developers and DevOps teams managing multiple software environments.

1 investor

Relativity Space develops Terran R, a reusable medium-to-heavy-lift rocket designed for efficiency and scalability, serving government entities, telecommunications companies, and commercial customers for space access missions. The company focuses on making space exploration more accessible, reliable, and sustainable.

16 investors

A mobile shopping app that alerts users to new releases, restocks, and sales from sneaker and streetwear brands, allowing them to check inventory and purchase directly within the platform.

1 investor

Revl develops AI-powered video capture and editing technology that automatically creates cinematic videos in real-time for experiential activities. The company targets the experience economy market, including adventure sports, cruises, and similar attractions.

3 investors

Salt Security provides an AI-infused platform for protecting APIs and applications from security threats across discovery, posture management, and runtime protection. The company serves businesses of all sizes seeking to secure their API infrastructure against attackers.

6 investors