Y Combinator Summer 2025 (S25) Companies

Nixo is a platform for forward deployed engineers (FDEs) that consolidates customer context, code intelligence, and workload visibility in one place. It automates customer intake, prevents duplicate work, and integrates with tools like Slack, GitHub, Linear, and CRMs to streamline FDE operations from discovery to deployment.

1 investor

Normal is an applied research lab focused on AI for hardware design, providing data and evaluation methods to advance AI capabilities. It serves engineers and companies building rockets, robots, aircraft, satellites, medical devices, and semiconductors.

1 investor

NOSO Labs develops AI agents that assist field technicians in the home services industry by improving diagnostic capabilities and identifying sales opportunities during service calls.

4 investors

Notte provides browser infrastructure and APIs for AI agents and automations to interact with websites and web applications. The platform offers distributed browser sessions, authentication management, and task automation capabilities designed for developers building AI-powered web automation tools.

3 investors

NovaFlow is an AI-powered data analysis platform that automates bioinformatics workflows for life science researchers and biotech labs, transforming raw experimental data into publication-ready results in minutes using large language models and validated computational pipelines.

2 investors

NOX operates AI-powered metal manufacturing facilities that provide cut-to-spec metal products to American manufacturers with quote and delivery times measured in milliseconds rather than days. The company uses machine learning for inventory optimization, job scheduling, and bin-packing to reduce lead times and scrap in metal supply.

10 investors

Nozomio develops AI products focused on improving how systems understand and maintain context in machine learning applications.

6 investors

Nuntius builds tools to ensure AI models comply with specified constraints and behave reliably in commercial applications.

1 investor

Okibi generates typed command-line interfaces (CLIs) from software code repositories using AI, making code executable and agent-friendly. The platform converts codebases into documented, versioned binaries that work natively with AI agents.

3 investors

Omnara provides an open-source platform for deploying, running, and managing AI agents through a unified API, available both as a self-hosted solution and managed cloud service.

2 investors

OnDeck develops video understanding technology for enterprise customers, leveraging vision language models grounded in real data to enhance reliability beyond standard off-the-shelf approaches.

6 investors

Interface researches how information is structured for AI agents and develops transaction platforms for them, including OneStop, a marketplace aggregating AI services.

5 investors

Opennote is an AI-powered learning platform that consolidates lecture materials, notes, and readings in one place and provides contextual explanations, practice tools, and video tutorials to help students understand course content.

3 investors

Orange Slice automates sales tasks using AI agents that identify prospects, enrich them with data from web research, and execute revenue workflows including CRM syncs and email outreach. The platform serves sales and revenue teams at SaaS companies and enterprises.

5 investors

Pally is a personal assistant that lives in iMessage and connects to multiple communication and productivity tools to automatically organize information from emails, messages, calendars, and documents. It proactively handles reminders, research, task management, and can make calls or complete bookings on behalf of users.

4 investors

Paloma builds operations management software for companies in manufacturing, logistics, and agriculture. The company works directly with physical operations teams to diagnose and solve workflow inefficiencies that are typically managed through spreadsheets and manual processes.

3 investors

Panels creates high-quality audio datasets for training and evaluating voice AI models, serving voice AI companies from early-stage startups to frontier research labs. The company offers both off-the-shelf and custom audio data products with optional exclusivity rights.

1 investor

Pangolin provides secure, zero-trust remote access to infrastructure using peer-to-peer tunnels and clientless browser access across on-premises, cloud, and edge environments. The open-source solution, based on WireGuard, verifies identity and context at every step.

3 investors

Panoptive provides a software platform that continuously monitors clinical trials by converting monitoring reports and electronic data capture (EDC) data into structured findings, documented decisions, and audit-ready oversight records. The platform serves sponsors and clinical operations teams conducting regulated trials and helps organizations surface quality issues early while maintaining inspection-ready documentation.

1 investor

Pares provides commercial real estate sales and advisory services, offering valuation guidance, investment property listing, and 1031 exchange facilitation for property investors and owners.

1 investor

Perseus Defense builds autonomous defense systems. The company focuses on next-generation autonomous technologies for defense applications.

9 investors

Perspectives Health provides AI-powered clinical documentation and utilization review management for healthcare providers. The platform automates nightly chart audits, generates utilization review packets, manages documentation workflows, and tracks compliance issues for clinical teams.

2 investors

Phases provides AI-powered oversight for clinical trials, using automated agents to detect operational issues, maintain data standards, and ensure regulatory compliance without manual intervention.

3 investors

Physical Turing conducts real-world testing and evaluation of humanoid robots in deployment environments like warehouses and factories. The company verifies whether robots can operate reliably outside controlled laboratory conditions before customer deployment.

2 investors