Level Ex
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Creates industry-leading mobile and AR training software and games for physicians.
Also known as Level Ex, Inc. · Relevate Health Games
Investors · 6
Also in the syndicate · 1
Company profile
researched Aug 2026Level Ex is a Chicago-based company that applies video game technology and development techniques to medical training and education. Its games are designed for practicing clinicians and cover specialties including cardiology, pulmonology, gastroenterology and anesthesiology, with additional specialties in development. Content is produced by combined teams of game developers, artists and physicians, with an emphasis on interactive quality and user experience comparable to consumer entertainment titles rather than conventional medical education material.
The company's work spans two areas that were later separated organizationally: clinical games aimed at medical professionals and the pharmaceutical industry, and games for surgeons and the medical device industry. Beyond commercial clinical titles, Level Ex partnered with The Translational Research Institute for Space Health (TRISH) on a virtual human simulation platform intended to help NASA train astronauts to handle medical situations in space.
Founding story
The company originated in 2012, when founder Sam Glassenberg's father, an anesthesiologist, asked him to use his video game development experience to build a game for practicing fiberoptic intubations. Glassenberg built the game over three weekends and published it to the app store for his father's colleagues; roughly 100,000 doctors, nurses and airway specialists ultimately played it. The scale of that unsolicited demand from physicians led him to found Level Ex in 2015. Glassenberg had previously been CEO of an independent Hollywood game publisher acquired by Playtech in 2016, led the DirectX team at Microsoft, and worked at LucasArts; he holds an M.S. in computer science (graphics) from Stanford and a B.S. in computer engineering from the University of Illinois Urbana-Champaign.
Business model
Level Ex develops medical video games and simulation content used for physician training and engagement, monetized through work for pharmaceutical companies, medical device manufacturers and medical societies rather than through the clinicians who play the titles. The post-2024 Relevate Health Games unit positions the games within broader omnichannel brand marketing and engagement programs for life sciences clients.
Traction
By 2020 the company reported more than 600,000 medical professionals playing its games, a figure later cited as over 1 million medical professionals. Clients included six of the top 10 pharmaceutical companies, global medical device companies and medical societies.
Latest developments
In 2024 Level Ex's Life Sciences division was acquired by Relevate Health and rebranded Relevate Health Games, offering clinical games for medical professionals and the pharmaceutical industry alongside omnichannel marketing services. The Surgical and Medical Device division continues within Brainlab's SNKE Group, serving surgeons and medical device companies.
▸Full profile — market position, technology, go-to-market, geography, history
Market position
Level Ex positions itself at the intersection of the video game and healthcare industries, arguing that clinicians expect the same interface and content quality as consumer software. It was named to Fast Company's Most Innovative list and, by 2020, had been described as a 100-plus-person company by MATTER's leadership.
Technology
The company uses techniques drawn from commercial video game development — including advanced graphics and interactive design — to model clinical procedures and patient physiology on mobile devices. Work with TRISH extended this into a virtual human simulation platform for training astronauts in medical scenarios.
Go-to-market
The company reaches clinicians directly through mobile app distribution of free-to-play medical games, while selling sponsorship and development engagements to pharmaceutical firms, medical device makers and medical societies. Early growth was supported by participation in the MATTER incubator community, its investor introductions and its innovation challenges.
Practicing physicians, nurses and other medical professionals are the end users of the games. Paying clients include pharmaceutical companies — six of the top 10 by the company's account — global medical device manufacturers and medical societies. Following the 2024 split, the clinical games business addresses medical professionals and the pharmaceutical industry, while the surgical business addresses surgeons and the medical device industry.
Geography
Headquartered in Chicago, Illinois, where it continued to operate after the Brainlab acquisition; parent Brainlab is based in Germany.
History
Level Ex was founded in 2015 in Chicago and joined the MATTER healthcare incubator the same year. MATTER introduced the company to Pritzker Group in 2016, which became a seed round investor, and in 2017 Level Ex won $50,000 through one of MATTER's healthcare challenges (the IPF Innovation Challenge). After its seed round the company moved out of MATTER's shared space into its own offices as headcount grew past 100 people. In July 2020 Level Ex was acquired by German digital medical technology company Brainlab, becoming a wholly owned subsidiary while continuing to operate in Chicago. In 2024 the Life Sciences division was acquired by Relevate Health and rebranded as Relevate Health Games; the Surgical and Medical Device division remains part of Brainlab's SNKE Group.
Compiled by commissioned research from 7 cited public sources — announcements, filings, and press listed under research sources below.
Key figures
latest reportedCompany-reported or press-reported figures, each dated to when it was claimed — not independently audited.
Timeline · 5
launches, deals, and filingsLevel Ex's Life Sciences division was acquired by Relevate Health and rebranded as Relevate Health Games; the Surgical and Medical Device division remained part of Brainlab's SNKE Group.
Level Ex was acquired by German digital medical technology company Brainlab, becoming a wholly owned subsidiary while continuing to operate and grow in Chicago.
Level Ex partnered with The Translational Research Institute for Space Health to help NASA create a virtual human simulation platform for training astronauts to handle medical situations in space.
Level Ex won $50,000 through one of MATTER's first healthcare challenges, the IPF Innovation Challenge.
$50K source ↗
Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.
In the news
▸Research sources · 7
primary sources listed
- Level Ex - New Name. Same Game.levelex.com · web
7 public sources were cited for this profile; the first-party ones are listed here.
Frequently asked questions
- What does Level Ex do?
- Chicago medical video game company building mobile and simulation games that train physicians across clinical specialties.
- Who are Level Ex's investors?
- Level Ex's investors include JAZZ Venture Partners, OSF Ventures, Service Provider Capital, 4490 Ventures, Pritzker Group Venture Capital.

