IsoPlexis
New Haven, US · Founded 2014 · Delaware corporation · 5 known investors
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IsoPlexis offers the Cell Analysis Suite (CAS), software for its Beacon optofluidic platform that lets researchers design, automate, and analyze functional live single-cell workflows. It serves life-science researchers working in areas such as antibody discovery, cell line development, T cell profiling, and adoptive cell therapy.
Founders & leadership
IsoPlexis was founded in 2014 by Rong Fan, Sean McKay, and Sean Mackay.
Board

Investors · 5
How we know: Connecticut Innovations's portfolio page · press coverage · Not right? Tell us
How we know: funding news · Not right? Tell us
How we know: press coverage · Not right? Tell us
How we know: board seat on SEC Form D · press coverage · Not right? Tell us
How we know: press coverage · Not right? Tell us
Funding
SEC filings, press & company announcements$127M disclosed across 7 of 8 rounds · 2014–2021
- Undisclosed amountIPOOct 2021Source ↗
▶$7.5MraisedJan 2021 · 1 investors · Other TechnologyRule 506(b)
- John StrahleyExecutive Officer
- Sean MackayExecutive Officer, Director
- John ConleyDirector
- GREGORY HODirector
- DANIEL WAGNERDirector
- JAMES HEATHDirector
- MICHAEL EGHOLMDirector
- SHARON KEDARDirector
- Offering amount
- $7.5M
- Amount sold
- $7.5M
- First sale
- Dec 2020
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$85MraisedJan 2021 · 10 investors · Other TechnologyRule 506(b)
- DANIEL WAGNERDirector
- GREGORY HODirector
- John ConleyDirector
- Sean MackayExecutive Officer, Director
- MICHAEL EGHOLMDirector
- SHARON KEDARDirector
- John StrahleyExecutive Officer
- JAMES HEATHDirector
- Offering amount
- $85M
- Amount sold
- $85M
- First sale
- Dec 2020
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$19.6MraisedNov 2018 · 6 investors · Other TechnologyRule 506(b)
- Daniel WagnerDirector
- Sean MackayExecutive Officer, Director
- James HeathDirector
- Gregory HoDirector
- John ConleyDirector
- Offering amount
- $25M
- Amount sold
- $19.6M
- First sale
- Nov 2018
- Incorporated
- Corporation, Delaware, 2014
- Federal exemptions
- 06b
▶$5.4MraisedAug 2017 · 4 investors · Other TechnologyRule 506(b)
- James HeathDirector
- John ConleyDirector
- Sean MackayExecutive Officer, Director
- Daniel WagnerDirector
- Gregory HoDirector
- Offering amount
- $6.4M
- Amount sold
- $5.4M
- First sale
- Jul 2017
- Incorporated
- Corporation, Delaware, 2014
- Federal exemptions
- 06b
▶$5.7MraisedJun 2016 · 5 investors · Other TechnologyRule 506(b)
- Sean McKayExecutive Officer, Director
- James HeathDirector
- Rong FanDirector
- Gregory HoDirector
- Daniel WagnerDirector
- Offering amount
- $8M
- Amount sold
- $5.7M
- First sale
- Jun 2016
- Incorporated
- Corporation, Delaware, 2014
- Federal exemptions
- 06b
▶$2.4MraisedMay 2015 · 4 investors · Other TechnologyRule 506(b)
- Daniel WagnerDirector
- John ConleyDirector
- Gregory HoDirector
- Rong FanDirector
- Sean McKayExecutive Officer, Director
- Offering amount
- $3.8M
- Amount sold
- $2.4M
- First sale
- May 2015
- Incorporated
- Corporation, Delaware, 2014
- Federal exemptions
- 06b
▶$1.3MraisedJul 2014 · 7 investors · BiotechnologyRule 506(b)
- Sean MackayExecutive Officer, Director
- Offering amount
- $1.7M
- Amount sold
- $1.3M
- First sale
- Jul 2014
- Incorporated
- Corporation, Delaware, 2013
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
Non-dilutive funding · 17 SBIR/STTR awards
Federal grants — no equity taken| Agency | Phase | Year | Amount |
|---|---|---|---|
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2020 | $2M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2019 | $4M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2019 | $2M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2019 | $2M |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2019 | $224.9K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2018 | $224.9K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2018 | $224.6K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2018 | $163.7K |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2017 | $1.9M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2017 | $1.9M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2017 | $1.8M |
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2017 | $1.7M |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2017 | $162.5K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2016 | $164K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2016 | $164K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2016 | $160.3K |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2015 | $182K |
Source: SBIR.gov award data (U.S. Small Business Administration). SBIR/STTR awards are competitive federal R&D grants and contracts — non-dilutive capital alongside any venture rounds above.
In the news
Frequently asked questions
- What does IsoPlexis do?
- IsoPlexis offers the Cell Analysis Suite (CAS), software for its Beacon optofluidic platform that lets researchers design, automate, and analyze functional live single-cell workflows. It serves life-science researchers working in areas such as antibody discovery, cell line development, T cell profiling, and adoptive cell therapy.
- Who founded IsoPlexis?
- IsoPlexis was founded by Rong Fan, Sean McKay, Sean Mackay in 2014.
- Who are IsoPlexis's investors?
- IsoPlexis's investors include Connecticut Innovations, Ally Bridge Group, Ironwood Capital, Northpond Ventures, Spring Mountain Capital.
- How much funding has IsoPlexis raised?
- IsoPlexis has disclosed $127M raised across 7 of its 8 known rounds.
- Where is IsoPlexis headquartered?
- IsoPlexis is headquartered in New Haven, US.
